iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045953

UUCD1 version

UUC-HoS-00790

Ensembl Protein ID

ENSP00000416177.2

UniProt Accession

Q8NA82; D3DU09; Q8IYS7; Q8N7Z7; MARHA_HUMAN

Genbank Protein ID

BAC04044.1; BAC05079.1; EAW94337.1; EAW94338.1; AAH35021.1

Protein Name

Probable E3 ubiquitin-protein ligase MARCH10; Membrane-associated RING finger protein 10; Membrane-associated RING-CH protein X; RING finger protein 190; RING-type E3 ubiquitin transferase MARCH10

Genbank Nucleotide ID

AK093076; AK097506; AC005821; CH471109; BC035021

Gene Name

MARCH10; RNF190

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000173838.11	ENST00000580520.5	ENSP00000464220.1
ENSG00000173838.11	ENST00000456609.6	ENSP00000416177.2
ENSG00000173838.11	ENST00000583600.5	ENSP00000463080.1
ENSG00000173838.11	ENST00000544856.6	ENSP00000443746.2
ENSG00000173838.11	ENST00000582568.1	ENSP00000463572.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	circRNADb	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	21937444

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.11	14.7	659	714

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.....kdgplvlpCgHv....f.hadClqkwpglknssskef.....rCPlC 45
           C iC   +     ++ pl+ pCg v    f h++Cl+kw ++ + +s+++     +C  C
   Q: 659  CRIC--QIaggspSN-PLLEPCGCVgslqFvHQECLKKW-LKVKITSGADlgavkTCEMC 714
           8888..332333378.999****98999966********.33333444432222247777 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MLHDARDRQK FFSDVQYLRD MQHKVDSEYQ ACLRRQEYRR DPNEKKRDQF WGQETSFERS 60
RFSSRSSSKQ SSSEEDALTE PRSSIKISAF KCDSKLPAID QTSVKQKHKS TMTVRKAEKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGCTAGG GAAACCGGAG GACGCCCGGT AGCCGCCCCC ACCGCCTCCG CCCCAGGCAA 60
GGCCGGCCGG CGCCGCGGAA AGCAGCCTCG GGGAAGGAGG AGGAAGAGGG GCAGGTGTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

KEGG

hsa:162333

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002345	Ailuropoda melanoleuca	71.74	0.00e+00	976.00
IUUC-Aca-004250	Anolis carolinensis	44.82	2.00e-61	231.00
IUUC-Bta-013138	Bos taurus	69.88	0.00e+00	867.00
IUUC-Cja-019793	Callithrix jacchus	81.58	0.00e+00	1135.00
IUUC-Cpo-021565	Cavia porcellus	62.50	4.00e-125	441.00
IUUC-Csa-024222	Chlorocebus sabaeus	87.17	0.00e+00	883.00
IUUC-Cho-024306	Choloepus hoffmanni	74.21	5.00e-147	514.00
IUUC-Dor-030702	Dipodomys ordii	55.36	0.00e+00	634.00
IUUC-Ete-033007	Echinops telfairi	49.50	3.00e-129	456.00
IUUC-Eca-034038	Equus caballus	75.55	0.00e+00	1016.00
IUUC-Fca-035583	Felis catus	73.17	0.00e+00	916.00
IUUC-Ggo-045166	Gorilla gorilla	97.28	0.00e+00	1329.00
IUUC-Itr-048662	Ictidomys tridecemlineatus	70.62	0.00e+00	929.00
IUUC-Lch-050154	Latimeria chalumnae	62.65	4.00e-35	143.00
IUUC-Laf-054183	Loxodonta africana	70.00	0.00e+00	779.00
IUUC-Meu-056145	Macropus eugenii	44.92	1.00e-59	224.00
IUUC-Mmr-061386	Microcebus murinus	72.17	0.00e+00	892.00
IUUC-Mpu-066649	Mustela putorius furo	72.03	0.00e+00	869.00
IUUC-Mlu-067404	Myotis lucifugus	66.96	0.00e+00	830.00
IUUC-Nle-070167	Nomascus leucogenys	90.84	0.00e+00	1259.00
IUUC-Opr-070961	Ochotona princeps	59.80	0.00e+00	662.00
IUUC-Ocu-074491	Oryctolagus cuniculus	61.64	0.00e+00	734.00
IUUC-Oar-089821	Ovis aries	69.32	0.00e+00	845.00
IUUC-Ptr-090789	Pan troglodytes	98.39	0.00e+00	1372.00
IUUC-Pan-092125	Papio anubis	90.97	0.00e+00	1215.00
IUUC-Pab-098370	Pongo abelii	94.93	0.00e+00	1315.00
IUUC-Pop-099336	Populus trichocarpa	44.26	7.00e-09	55.50
IUUC-Pca-100716	Procavia capensis	59.11	0.00e+00	724.00
IUUC-Pva-102277	Pteropus vampyrus	72.09	0.00e+00	895.00
IUUC-Rno-105197	Rattus norvegicus	60.56	0.00e+00	750.00
IUUC-Sha-107288	Sarcophilus harrisii	56.46	0.00e+00	629.00
IUUC-Ssc-115620	Sus scrofa	67.76	0.00e+00	790.00
IUUC-Tbe-127829	Tupaia belangeri	73.17	0.00e+00	853.00
IUUC-Ttr-128353	Tursiops truncatus	75.44	3.00e-135	476.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence