iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053363

UUCD1 version

UUC-LoA-00307

Ensembl Protein ID

ENSLAFP00000007424.2

UniProt Accession

G3T2M2; G3T2M2_LOXAF

Protein Name

Uncharacterized protein

Gene Name

RNF125

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000008839.2	ENSLAFT00000008838.2	ENSLAFP00000007424.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.60e-10	39.8	33	98
E3 activity/RING/RING	1.70e-08	35.2	37	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawc 69
             f C++ le+ ++Pv + +G+++ rs+I+  l++++ tcP +r+ l +e +    + +r+ +++ 
   Q: 33   TSFDCSVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYQ 98
           579******************************99999*********9999999999999999885 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cle + + p+ ++CgHvf+++C+   +      ++++++CP+Cr
   Q: 37   CSVCLEVLHQ-PVRTRCGHVFCRSCIaTSL------KNNKWTCPYCR 76
           ********99.777***********95555......**********8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MGSVLSSDSG KSAPASATPR DLERRGSPEL PVTSFDCSVC LEVLHQPVRT RCGHVFCRSC 60
IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYQNC TECDTLVCLS EMRAHIRTCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTCCG TGCTGAGCAG CGACAGCGGC AAATCCGCGC CTGCCTCGGC CACCCCGCGG 60
GACCTGGAGC GCAGGGGGAG CCCCGAGCTG CCAGTCACGT CCTTCGACTG TTCCGTGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001992	Ailuropoda melanoleuca	91.45	3.00e-127	446.00
IUUC-Aca-004839	Anolis carolinensis	61.88	1.00e-65	241.00
IUUC-Bta-012827	Bos taurus	90.60	3.00e-126	443.00
IUUC-Cja-018794	Callithrix jacchus	91.03	1.00e-125	441.00
IUUC-Cfa-021234	Canis familiaris	90.60	2.00e-117	414.00
IUUC-Cpo-022412	Cavia porcellus	79.06	5.00e-105	373.00
IUUC-Csa-023406	Chlorocebus sabaeus	91.88	2.00e-126	444.00
IUUC-Cho-024427	Choloepus hoffmanni	76.54	8.00e-75	272.00
IUUC-Dno-030085	Dasypus novemcinctus	91.03	9.00e-126	442.00
IUUC-Dor-030911	Dipodomys ordii	68.80	2.00e-74	271.00
IUUC-Ete-032469	Echinops telfairi	87.61	3.00e-122	430.00
IUUC-Eca-034352	Equus caballus	92.31	3.00e-127	447.00
IUUC-Eeu-034889	Erinaceus europaeus	76.50	2.00e-100	358.00
IUUC-Fca-036116	Felis catus	91.03	1.00e-118	418.00
IUUC-Hsa-046518	Homo sapiens	91.45	2.00e-125	440.00
IUUC-Itr-048344	Ictidomys tridecemlineatus	95.53	9.00e-100	355.00
IUUC-Meu-056101	Macropus eugenii	80.28	2.00e-99	354.00
IUUC-Mdo-062046	Monodelphis domestica	77.45	8.00e-103	365.00
IUUC-Mmu-063184	Mus musculus	82.39	1.00e-56	211.00
IUUC-Mpu-065708	Mustela putorius furo	90.60	1.00e-125	441.00
IUUC-Mlu-067561	Myotis lucifugus	86.59	1.00e-91	328.00
IUUC-Nle-069665	Nomascus leucogenys	92.13	2.00e-116	410.00
IUUC-Opr-070301	Ochotona princeps	80.34	1.00e-106	378.00
IUUC-Ocu-074562	Oryctolagus cuniculus	91.41	2.00e-66	243.00
IUUC-Oga-088958	Otolemur garnettii	92.74	6.00e-128	449.00
IUUC-Oar-089541	Ovis aries	91.06	1.00e-96	344.00
IUUC-Ptr-090989	Pan troglodytes	91.88	2.00e-126	444.00
IUUC-Pan-092372	Papio anubis	91.03	1.00e-125	441.00
IUUC-Pab-098718	Pongo abelii	78.63	5.00e-102	362.00
IUUC-Pca-100453	Procavia capensis	95.30	1.00e-130	458.00
IUUC-Pva-102931	Pteropus vampyrus	92.31	3.00e-119	420.00
IUUC-Rno-105771	Rattus norvegicus	86.45	6.00e-99	353.00
IUUC-Sha-107557	Sarcophilus harrisii	76.17	4.00e-106	376.00
IUUC-Sar-113435	Sorex araneus	90.62	3.00e-66	242.00
IUUC-Ssc-116388	Sus scrofa	91.88	2.00e-127	447.00
IUUC-Tsy-119439	Tarsius syrichta	92.74	1.00e-97	347.00
IUUC-Tbe-127417	Tupaia belangeri	68.45	4.00e-71	260.00
IUUC-Ttr-129212	Tursiops truncatus	92.31	4.00e-128	450.00
IUUC-Vpa-130153	Vicugna pacos	90.60	4.00e-125	439.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence