iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045829

Ensembl Protein ID

ENSP00000439781.1

UniProt Accession

A1YPR0; O73453; ZBT7C_HUMAN

Genbank Protein ID

CAA74933.1; ABL98073.1

Protein Name

Zinc finger and BTB domain-containing protein 7C; Affected by papillomavirus DNA integration in ME180 cells protein 1; Zinc finger and BTB domain-containing protein 36; Zinc finger protein 857C

Genbank Nucleotide ID

Y14591; EF120357

Gene Name

ZBTB7C; APM1; ZBTB36; ZNF857C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000184828.9	ENST00000535628.6	ENSP00000439781.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	JASPAR	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.70e-16	61.4	34	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+lvv+++e+++h++vLaa+S++F++lf+ +   s+    +ei+ vqpe++ a+l+F Yt++l++
   Q: 34   CDVLLVVQEQEYRTHRSVLAACSKYFKKLFTAGTLASQ-PYVYEIDFVQPEALAAILEFAYTSTLTI 99
           9************************************9.************************9976 PP

Organism

Homo sapiens

Functional Description
(View)

May be a tumor suppressor gene.

Protein Sequence
(Fasta)

MANDIDELIG IPFPNHSSEV LCSLNEQRHD GLLCDVLLVV QEQEYRTHRS VLAACSKYFK 60
KLFTAGTLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT AGNVKHILNA ARMLEIQCIV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCCGATG TACTACCAAG GAGGGCGAGG GTTCCTATGT CTGTCTGGAG CGCAGAGGGG 60
TGGACTGCAA AAAGGTAGGA GGCAAAGCCA GCTCGAGTTT CCCCGGCCCG TAGCTGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0043--Tumor suppressor
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016024--ARM-type_fold
IPR000210--BTB/POZ_dom
IPR012677--Nucleotide-bd_a/b_plait
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:0045600--P:positive regulation of fat cell differentiation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

KEGG

hsa:201501

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001546	Ailuropoda melanoleuca	78.71	0.00e+00	761.00
IUUC-Aca-005243	Anolis carolinensis	73.58	0.00e+00	810.00
IUUC-Ame-010701	Astyanax mexicanus	55.61	4.00e-104	372.00
IUUC-Bta-013295	Bos taurus	94.02	0.00e+00	1011.00
IUUC-Cja-018739	Callithrix jacchus	97.58	0.00e+00	1030.00
IUUC-Cfa-020852	Canis familiaris	92.93	0.00e+00	942.00
IUUC-Cpo-021909	Cavia porcellus	95.16	0.00e+00	1028.00
IUUC-Csa-023671	Chlorocebus sabaeus	97.74	0.00e+00	1028.00
IUUC-Dre-027794	Danio rerio	53.29	4.00e-160	558.00
IUUC-Dno-029000	Dasypus novemcinctus	95.75	0.00e+00	792.00
IUUC-Dor-030312	Dipodomys ordii	94.51	0.00e+00	961.00
IUUC-Ete-032624	Echinops telfairi	85.32	1.00e-170	592.00
IUUC-Eca-033481	Equus caballus	98.22	0.00e+00	1023.00
IUUC-Eeu-035288	Erinaceus europaeus	84.35	3.00e-165	574.00
IUUC-Fca-036011	Felis catus	95.16	0.00e+00	1007.00
IUUC-Fal-036885	Ficedula albicollis	69.94	0.00e+00	795.00
IUUC-Gmo-039261	Gadus morhua	85.91	1.00e-77	284.00
IUUC-Gga-040337	Gallus gallus	76.33	0.00e+00	837.00
IUUC-Gac-042323	Gasterosteus aculeatus	86.14	7.00e-87	314.00
IUUC-Ggo-045440	Gorilla gorilla	99.68	0.00e+00	1036.00
IUUC-Itr-048052	Ictidomys tridecemlineatus	97.90	0.00e+00	1001.00
IUUC-Lch-049875	Latimeria chalumnae	60.77	0.00e+00	709.00
IUUC-Loc-052483	Lepisosteus oculatus	54.83	2.00e-108	386.00
IUUC-Laf-054036	Loxodonta africana	97.09	0.00e+00	982.00
IUUC-Meu-056614	Macropus eugenii	89.35	0.00e+00	999.00
IUUC-Mga-060118	Meleagris gallopavo	72.03	1.00e-148	519.00
IUUC-Mdo-062777	Monodelphis domestica	90.16	0.00e+00	1005.00
IUUC-Mmu-064243	Mus musculus	94.18	0.00e+00	987.00
IUUC-Mpu-066631	Mustela putorius furo	97.25	0.00e+00	1027.00
IUUC-Mlu-067842	Myotis lucifugus	96.45	0.00e+00	1042.00
IUUC-Nle-069214	Nomascus leucogenys	98.87	0.00e+00	1036.00
IUUC-Opr-071188	Ochotona princeps	87.68	0.00e+00	936.00
IUUC-Ont-071774	Oreochromis niloticus	87.06	3.00e-91	329.00
IUUC-Oan-072960	Ornithorhynchus anatinus	80.45	1.00e-157	549.00
IUUC-Ocu-074040	Oryctolagus cuniculus	91.07	0.00e+00	931.00
IUUC-Ola-087532	Oryzias latipes	57.52	7.00e-152	530.00
IUUC-Oga-087996	Otolemur garnettii	96.28	0.00e+00	1007.00
IUUC-Oar-090238	Ovis aries	86.25	0.00e+00	900.00
IUUC-Ptr-090742	Pan troglodytes	99.84	0.00e+00	1041.00
IUUC-Pan-092309	Papio anubis	98.06	0.00e+00	1030.00
IUUC-Psi-093613	Pelodiscus sinensis	75.36	0.00e+00	871.00
IUUC-Pfo-096699	Poecilia formosa	48.58	2.00e-101	363.00
IUUC-Pab-097784	Pongo abelii	98.06	0.00e+00	1033.00
IUUC-Pva-102463	Pteropus vampyrus	98.76	0.00e+00	657.00
IUUC-Rno-105055	Rattus norvegicus	94.51	0.00e+00	968.00
IUUC-Sha-107012	Sarcophilus harrisii	89.35	0.00e+00	983.00
IUUC-Sar-113172	Sorex araneus	89.88	0.00e+00	896.00
IUUC-Ssc-115309	Sus scrofa	89.86	0.00e+00	894.00
IUUC-Tgu-116832	Taeniopygia guttata	74.19	0.00e+00	829.00
IUUC-Tru-117579	Takifugu rubripes	71.11	4.00e-105	375.00
IUUC-Tni-120538	Tetraodon nigroviridis	85.28	7.00e-85	308.00
IUUC-Tbe-127883	Tupaia belangeri	98.01	0.00e+00	651.00
IUUC-Ttr-128944	Tursiops truncatus	96.34	0.00e+00	714.00
IUUC-Xtr-132858	Xenopus tropicalis	64.99	0.00e+00	716.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence