iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074783

Ensembl Protein ID

ENSOCUP00000023883.1

UniProt Accession

G1U3C3; G1U3C3_RABIT

Genbank Protein ID

ENSOCUP00000023883

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02007616

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000025486.2	ENSOCUT00000026908.2	ENSOCUP00000023883.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-45	152.7	197	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+++g+ Gl+P+n+v+ l+
   Q: 197  LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNARGQVGLVPKNYVVVLS 256
           689**************************************.7**************9886 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVRN LKDTLGLGKT RRKPSARDAS PTPSTDAEYP SNGSGADRIY DLNIPAFVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCTTCTGA TCCCAGTGTG CTCAGCGGCC CAGAACTTCC CACGGCTCCC TGAAGGGTTT 60
TTAAATAACC CAGTCTCCAG CCCTCCCTTC CCTCCCAGCG GTGTGGGTGG AGCTGCAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

ocu:100353755

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	97.11	0.00e+00	727.00
IUUC-Apl-003456	Anas platyrhynchos	91.84	0.00e+00	703.00
IUUC-Aca-005105	Anolis carolinensis	91.58	0.00e+00	705.00
IUUC-Ame-010966	Astyanax mexicanus	79.11	1.00e-175	608.00
IUUC-Bta-012424	Bos taurus	88.42	0.00e+00	633.00
IUUC-Cja-019898	Callithrix jacchus	97.37	0.00e+00	729.00
IUUC-Cfa-020830	Canis familiaris	96.58	0.00e+00	723.00
IUUC-Cpo-021487	Cavia porcellus	87.89	0.00e+00	648.00
IUUC-Csa-023693	Chlorocebus sabaeus	97.37	0.00e+00	729.00
IUUC-Cin-025348	Ciona intestinalis	37.30	5.00e-67	248.00
IUUC-Dre-028334	Danio rerio	80.68	4.00e-175	607.00
IUUC-Dno-028973	Dasypus novemcinctus	93.68	0.00e+00	710.00
IUUC-Dor-031003	Dipodomys ordii	95.00	0.00e+00	701.00
IUUC-Ete-032792	Echinops telfairi	84.64	0.00e+00	634.00
IUUC-Eca-033656	Equus caballus	97.11	0.00e+00	727.00
IUUC-Fca-036347	Felis catus	97.11	0.00e+00	727.00
IUUC-Fal-037095	Ficedula albicollis	91.58	0.00e+00	704.00
IUUC-Gmo-039410	Gadus morhua	71.68	4.00e-159	553.00
IUUC-Gga-040155	Gallus gallus	91.84	0.00e+00	703.00
IUUC-Gac-041787	Gasterosteus aculeatus	73.60	3.00e-165	574.00
IUUC-Ggo-044805	Gorilla gorilla	97.63	0.00e+00	730.00
IUUC-Hsa-046585	Homo sapiens	97.63	0.00e+00	730.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	97.37	0.00e+00	724.00
IUUC-Lch-049795	Latimeria chalumnae	87.89	0.00e+00	676.00
IUUC-Loc-051985	Lepisosteus oculatus	87.37	0.00e+00	652.00
IUUC-Laf-054228	Loxodonta africana	93.95	0.00e+00	711.00
IUUC-Mcc-055402	Macaca mulatta	97.37	0.00e+00	729.00
IUUC-Mga-059374	Meleagris gallopavo	91.84	0.00e+00	703.00
IUUC-Mmr-061453	Microcebus murinus	97.37	0.00e+00	729.00
IUUC-Mdo-063080	Monodelphis domestica	91.05	0.00e+00	699.00
IUUC-Mmu-063529	Mus musculus	95.26	0.00e+00	716.00
IUUC-Mpu-066815	Mustela putorius furo	97.11	0.00e+00	727.00
IUUC-Mlu-067132	Myotis lucifugus	93.77	4.00e-157	546.00
IUUC-Nle-069371	Nomascus leucogenys	97.63	0.00e+00	730.00
IUUC-Opr-070948	Ochotona princeps	97.35	0.00e+00	704.00
IUUC-Ont-071410	Oreochromis niloticus	74.56	5.00e-160	556.00
IUUC-Oan-073304	Ornithorhynchus anatinus	90.85	9.00e-159	552.00
IUUC-Ola-086808	Oryzias latipes	72.75	7.00e-157	546.00
IUUC-Oga-088391	Otolemur garnettii	97.89	0.00e+00	726.00
IUUC-Oar-090025	Ovis aries	82.11	2.00e-168	584.00
IUUC-Ptr-090975	Pan troglodytes	97.63	0.00e+00	730.00
IUUC-Pan-092287	Papio anubis	97.37	0.00e+00	729.00
IUUC-Psi-093413	Pelodiscus sinensis	92.11	0.00e+00	705.00
IUUC-Pfo-097129	Poecilia formosa	75.95	4.00e-164	570.00
IUUC-Pab-098756	Pongo abelii	97.63	0.00e+00	730.00
IUUC-Pca-100235	Procavia capensis	80.79	1.00e-179	622.00
IUUC-Pva-102294	Pteropus vampyrus	93.95	0.00e+00	693.00
IUUC-Rno-105090	Rattus norvegicus	95.26	0.00e+00	715.00
IUUC-Sha-107521	Sarcophilus harrisii	91.58	0.00e+00	702.00
IUUC-Sar-113697	Sorex araneus	89.84	0.00e+00	667.00
IUUC-Ssc-115958	Sus scrofa	87.97	4.00e-161	560.00
IUUC-Tgu-116559	Taeniopygia guttata	89.74	0.00e+00	678.00
IUUC-Tru-117677	Takifugu rubripes	75.95	3.00e-163	567.00
IUUC-Tni-120434	Tetraodon nigroviridis	75.77	6.00e-163	566.00
IUUC-Tbe-127931	Tupaia belangeri	95.57	9.00e-176	608.00
IUUC-Ttr-128993	Tursiops truncatus	87.89	0.00e+00	649.00
IUUC-Xtr-132543	Xenopus tropicalis	84.51	0.00e+00	659.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence