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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064269
UUCD1 version UUC-MuM-00947
Ensembl Protein ID ENSMUSP00000044913.1
UniProt Accession Q9D9X6; ZSWM2_MOUSE
Genbank Protein ID BAB24549.1
Protein Name E3 ubiquitin-protein ligase Zswim2; MEKK1-related protein X; RING-type E3 ubiquitin transferase Zswim2; ZZ-type zinc finger-containing protein 2; Zinc finger SWIM domain-containing protein 2
Genbank Nucleotide ID AK006367
Gene Name Zswim2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000034552.8 ENSMUST00000038223.7 ENSMUSP00000044913.1
ENSMUSG00000034552.8 ENSMUST00000152829.1 ENSMUSP00000119439.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 68.03 0.00e+00 884.00 IUUC-Hsa-046776
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.
 E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.
Protein Sequence
(Fasta)
MLRGGCKASE KRRHLSESLS WQQDQALSSS IYLLRQIGPT GFLLKEEEPE KGDFRVLLGN 60
PHECSCPTFL KRGELCKHIC WVLLKKFKLP RNHESAFQLG LTEGEINDLL RGIHQVQAPQ 120
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Protein Fasta Sequence


>IUUC-Mmu-064269|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
ATAGAGACCC AAGGCGCCTC AGAAAGCTAG AGGCTCCACG GCCGCCAGGG ATGCTTCGCG 60
GAGGCTGTAA AGCCTCAGAA AAGCGAAGAC ACTTAAGCGA GAGCCTCAGC TGGCAGCAAG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064269|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR007527--Znf_SWIM
IPR000433--Znf_ZZ
PROSITE

PS50089--ZF_RING_2
PS50966--ZF_SWIM
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF04434--SWIM
PF13639--zf-RING_2
SMART

SM00184--RING
SM00291--ZnF_ZZ
Gene Ontology

GO:0043621--F:protein self-association
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:1902043--P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0000209--P:protein polyubiquitination
KEGG mmu:71861
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001754 Ailuropoda melanoleuca 69.65 0.00e+00 894.00
IUUC-Apl-003359 Anas platyrhynchos 56.92 2.00e-41 160.00
IUUC-Aca-004923 Anolis carolinensis 55.58 9.00e-119 420.00
IUUC-Afl-008716 Aspergillus flavus 29.53 8.00e-14 71.20
IUUC-Ani-009202 Aspergillus nidulans 32.21 1.00e-13 70.90
IUUC-Bta-012456 Bos taurus 65.67 0.00e+00 856.00
IUUC-Cja-019186 Callithrix jacchus 65.98 0.00e+00 829.00
IUUC-Cfa-020604 Canis familiaris 66.95 0.00e+00 804.00
IUUC-Cpo-021774 Cavia porcellus 64.08 0.00e+00 809.00
IUUC-Cre-022861 Chlamydomonas reinhardtii 31.84 3.00e-28 119.00
IUUC-Csa-024126 Chlorocebus sabaeus 67.87 0.00e+00 858.00
IUUC-Cho-024501 Choloepus hoffmanni 72.68 3.00e-162 564.00
IUUC-Cin-025662 Ciona intestinalis 43.66 3.00e-95 342.00
IUUC-Cgl-026506 Colletotrichum gloeosporioides 28.42 7.00e-10 57.80
IUUC-Cne-027076 Cryptococcus neoformans 26.70 3.00e-13 70.10
IUUC-Dre-028700 Danio rerio 44.19 2.00e-108 386.00
IUUC-Dno-030007 Dasypus novemcinctus 66.35 0.00e+00 865.00
IUUC-Dor-030562 Dipodomys ordii 57.77 0.00e+00 664.00
IUUC-Dse-031237 Dothistroma septosporum 27.22 2.00e-10 59.70
IUUC-Ete-032603 Echinops telfairi 67.24 9.00e-139 486.00
IUUC-Eca-033283 Equus caballus 67.83 0.00e+00 857.00
IUUC-Eeu-034619 Erinaceus europaeus 60.69 0.00e+00 774.00
IUUC-Fca-035573 Felis catus 69.45 0.00e+00 906.00
IUUC-Fso-038137 Fusarium solani 27.17 8.00e-12 64.30
IUUC-Ggr-039924 Gaeumannomyces graminis 28.40 2.00e-10 59.70
IUUC-Ggo-045207 Gorilla gorilla 68.03 0.00e+00 866.00
IUUC-Hsa-046776 Homo sapiens 68.03 0.00e+00 861.00
IUUC-Itr-048416 Ictidomys tridecemlineatus 68.71 0.00e+00 892.00
IUUC-Lch-050394 Latimeria chalumnae 50.00 6.00e-136 478.00
IUUC-Loc-052123 Lepisosteus oculatus 50.34 6.00e-128 451.00
IUUC-Lma-053033 Leptosphaeria maculans 33.78 3.00e-13 68.90
IUUC-Laf-053456 Loxodonta africana 65.88 0.00e+00 842.00
IUUC-Mcc-055227 Macaca mulatta 68.03 0.00e+00 862.00
IUUC-Meu-055957 Macropus eugenii 59.69 3.00e-88 318.00
IUUC-Mor-056933 Magnaporthe oryzae 25.57 1.00e-09 57.00
IUUC-Mmr-061710 Microcebus murinus 68.71 0.00e+00 880.00
IUUC-Mdo-062378 Monodelphis domestica 53.55 0.00e+00 638.00
IUUC-Mpu-066736 Mustela putorius furo 65.60 0.00e+00 792.00
IUUC-Mlu-067142 Myotis lucifugus 57.04 0.00e+00 671.00
IUUC-Nfi-068477 Neosartorya fischeri 31.18 2.00e-12 66.60
IUUC-Ncr-068657 Neurospora crassa 30.20 4.00e-12 65.10
IUUC-Nle-069268 Nomascus leucogenys 68.50 0.00e+00 884.00
IUUC-Opr-071154 Ochotona princeps 58.37 1.00e-139 490.00
IUUC-Oan-072878 Ornithorhynchus anatinus 38.08 7.00e-47 181.00
IUUC-Ocu-074017 Oryctolagus cuniculus 66.89 0.00e+00 802.00
IUUC-Oga-088906 Otolemur garnettii 65.46 0.00e+00 846.00
IUUC-Oar-089422 Ovis aries 66.61 0.00e+00 873.00
IUUC-Ptr-090772 Pan troglodytes 67.87 0.00e+00 860.00
IUUC-Pan-092838 Papio anubis 67.72 0.00e+00 844.00
IUUC-Psi-093288 Pelodiscus sinensis 50.00 6.00e-137 480.00
IUUC-Pma-094709 Petromyzon marinus 45.64 1.00e-104 373.00
IUUC-Pfo-096189 Poecilia formosa 40.80 8.00e-94 337.00
IUUC-Pab-098389 Pongo abelii 63.31 0.00e+00 781.00
IUUC-Pca-100376 Procavia capensis 58.36 0.00e+00 710.00
IUUC-Pva-102163 Pteropus vampyrus 66.82 0.00e+00 837.00
IUUC-Pte-104391 Pyrenophora teres 29.57 3.00e-14 72.40
IUUC-Pyt-104706 Pyrenophora triticirepentis 30.87 4.00e-14 72.00
IUUC-Rno-105988 Rattus norvegicus 89.22 0.00e+00 1171.00
IUUC-Sha-107063 Sarcophilus harrisii 53.58 1.00e-180 626.00
IUUC-Sar-113069 Sorex araneus 61.99 0.00e+00 796.00
IUUC-Ssc-116112 Sus scrofa 66.04 0.00e+00 820.00
IUUC-Tsy-118825 Tarsius syrichta 71.63 0.00e+00 740.00
IUUC-Tbe-127891 Tupaia belangeri 65.41 0.00e+00 830.00
IUUC-Ttr-129130 Tursiops truncatus 65.59 0.00e+00 722.00
IUUC-Vda-129853 Verticillium dahliae 25.82 3.00e-08 52.80
IUUC-Vpa-130753 Vicugna pacos 66.35 0.00e+00 851.00
Created Date 25-Jun-2017

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