iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000020696.5	ENSBTAT00000038307.3	ENSBTAP00000038122.3
ENSBTAG00000020696.5	ENSBTAT00000063835.1	ENSBTAP00000054310.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.10e-122	407.9	1102	1434

Active Site

Position(s)	Description	Evidence
1402	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1102 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1187
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1188 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1270
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1271 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1357
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1358 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1434
           **************************************************************************985 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

EIKICFKYYH GISGALRATT PCITVKNPAV MVKKVLYSTE TSGNQHSRKL VSFTLSDLRA 60
VGLKKGMFFN PDPYLKMSIQ PGKKSSFPTC AHHGQERRST IISNTTNPIW HREKYSFFAL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGATAAAAA TCTGTTTCAA ATACTACCAC GGCATCAGTG GAGCCCTGCG AGCCACGACC 60
CCTTGCATCA CGGTGAAGAA CCCAGCTGTG ATGGTGAGTG CCCCTCCATG CCCACTTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	96.60	0.00e+00	1585.00
IUUC-Apl-003935	Anas platyrhynchos	94.97	0.00e+00	1568.00
IUUC-Aca-004558	Anolis carolinensis	94.70	0.00e+00	1553.00
IUUC-Ame-010893	Astyanax mexicanus	88.47	0.00e+00	1305.00
IUUC-Cja-019651	Callithrix jacchus	96.08	0.00e+00	1567.00
IUUC-Cfa-021232	Canis familiaris	96.47	0.00e+00	1575.00
IUUC-Cpo-021770	Cavia porcellus	95.59	0.00e+00	1597.00
IUUC-Csa-023970	Chlorocebus sabaeus	96.22	0.00e+00	1579.00
IUUC-Cho-024512	Choloepus hoffmanni	87.30	0.00e+00	1350.00
IUUC-Csv-026127	Ciona savignyi	72.27	5.00e-155	540.00
IUUC-Dre-028275	Danio rerio	86.83	0.00e+00	1425.00
IUUC-Dno-029963	Dasypus novemcinctus	95.46	0.00e+00	1560.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	659.00
IUUC-Ete-033132	Echinops telfairi	80.16	0.00e+00	1210.00
IUUC-Eca-033978	Equus caballus	96.47	0.00e+00	1576.00
IUUC-Fca-036157	Felis catus	96.22	0.00e+00	1569.00
IUUC-Fal-037110	Ficedula albicollis	95.08	0.00e+00	1561.00
IUUC-Gmo-039291	Gadus morhua	80.16	0.00e+00	1016.00
IUUC-Gga-040821	Gallus gallus	95.33	0.00e+00	1570.00
IUUC-Gac-042181	Gasterosteus aculeatus	88.32	0.00e+00	1420.00
IUUC-Ggo-044862	Gorilla gorilla	96.60	0.00e+00	1585.00
IUUC-Hsa-046219	Homo sapiens	96.47	0.00e+00	1612.00
IUUC-Lch-050526	Latimeria chalumnae	89.91	0.00e+00	1477.00
IUUC-Loc-052648	Lepisosteus oculatus	89.07	0.00e+00	1463.00
IUUC-Laf-054005	Loxodonta africana	96.34	0.00e+00	1583.00
IUUC-Mcc-055314	Macaca mulatta	96.47	0.00e+00	1583.00
IUUC-Meu-056356	Macropus eugenii	81.10	0.00e+00	794.00
IUUC-Mga-060074	Meleagris gallopavo	94.98	0.00e+00	1491.00
IUUC-Mmr-061526	Microcebus murinus	96.47	0.00e+00	1583.00
IUUC-Mdo-063017	Monodelphis domestica	95.71	0.00e+00	1534.00
IUUC-Mmu-064165	Mus musculus	96.22	0.00e+00	1580.00
IUUC-Mpu-065835	Mustela putorius furo	98.43	0.00e+00	1545.00
IUUC-Mlu-067709	Myotis lucifugus	94.83	0.00e+00	1541.00
IUUC-Nle-069308	Nomascus leucogenys	96.47	0.00e+00	1586.00
IUUC-Opr-070330	Ochotona princeps	82.35	0.00e+00	1304.00
IUUC-Ont-071345	Oreochromis niloticus	86.57	0.00e+00	1417.00
IUUC-Ocu-074775	Oryctolagus cuniculus	96.72	0.00e+00	1586.00
IUUC-Ola-087225	Oryzias latipes	82.27	0.00e+00	1307.00
IUUC-Oga-088177	Otolemur garnettii	96.47	0.00e+00	1583.00
IUUC-Oar-089452	Ovis aries	96.85	0.00e+00	1587.00
IUUC-Ptr-090806	Pan troglodytes	96.47	0.00e+00	1587.00
IUUC-Pan-091838	Papio anubis	96.35	0.00e+00	1578.00
IUUC-Psi-094090	Pelodiscus sinensis	94.72	0.00e+00	1524.00
IUUC-Pfo-096520	Poecilia formosa	86.22	0.00e+00	1410.00
IUUC-Pab-098405	Pongo abelii	96.60	0.00e+00	1587.00
IUUC-Pva-102324	Pteropus vampyrus	96.10	0.00e+00	1568.00
IUUC-Rno-105943	Rattus norvegicus	96.09	0.00e+00	1579.00
IUUC-Sha-106985	Sarcophilus harrisii	92.43	0.00e+00	1488.00
IUUC-Sar-113505	Sorex araneus	92.56	0.00e+00	1483.00
IUUC-Ssc-115534	Sus scrofa	100.00	0.00e+00	763.00
IUUC-Tgu-117078	Taeniopygia guttata	94.72	0.00e+00	1559.00
IUUC-Tru-118671	Takifugu rubripes	85.68	0.00e+00	1395.00
IUUC-Tni-120619	Tetraodon nigroviridis	85.48	0.00e+00	1394.00
IUUC-Ttr-128469	Tursiops truncatus	85.62	0.00e+00	1342.00
IUUC-Vpa-130498	Vicugna pacos	78.34	0.00e+00	1155.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence