iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089997

Ensembl Protein ID

ENSOARP00000020106.1

UniProt Accession

W5QBK9; W5QBK9_SHEEP

Genbank Protein ID

ENSOARP00000020106

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AMGL01000361

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000018722.1	ENSOART00000020384.1	ENSOARP00000020106.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	84.83	0.00e+00	1434.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ovis aries

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MQRRGPWAGA CSHSPPLSPA PGAVASTEVK MKLQEFVLNK KKALAHRNLN HCMSSDPRYW 60
YGKTQHSSLD QSSPPQSGAS ASYNHPVLGM YDAKDDFPLR KTASEPNLKL RSRLKQKVAE 120

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Nucleotide Sequence
(Fasta)

ATGCAGCGCA GGGGGCCCTG GGCTGGAGCC TGCAGTCACT CGCCCCCGCT CTCTCCCGCG 60
CCAGGCGCCG TGGCCAGCAC GGAAGTGAAG ATGAAGCTGC AGGAGTTTGT CCTCAATAAA 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR017320--Histone_deAcase_II_euk

Pfam

PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	84.22	0.00e+00	1420.00
IUUC-Apl-003250	Anas platyrhynchos	89.08	0.00e+00	976.00
IUUC-Aca-004668	Anolis carolinensis	85.59	0.00e+00	965.00
IUUC-Bta-013215	Bos taurus	89.42	0.00e+00	1526.00
IUUC-Cja-019816	Callithrix jacchus	84.30	0.00e+00	1457.00
IUUC-Cfa-020861	Canis familiaris	84.57	0.00e+00	1436.00
IUUC-Cpo-021562	Cavia porcellus	82.77	0.00e+00	1440.00
IUUC-Csa-023612	Chlorocebus sabaeus	83.62	0.00e+00	1421.00
IUUC-Csv-026359	Ciona savignyi	53.04	2.00e-89	321.00
IUUC-Dre-028284	Danio rerio	84.93	0.00e+00	831.00
IUUC-Dno-029951	Dasypus novemcinctus	81.67	0.00e+00	1330.00
IUUC-Dor-030362	Dipodomys ordii	72.23	0.00e+00	1150.00
IUUC-Dme-031766	Drosophila melanogaster	57.28	1.00e-152	534.00
IUUC-Fca-036187	Felis catus	86.12	0.00e+00	1496.00
IUUC-Gmo-038473	Gadus morhua	75.37	0.00e+00	719.00
IUUC-Gga-040501	Gallus gallus	89.08	0.00e+00	974.00
IUUC-Gac-042335	Gasterosteus aculeatus	83.44	0.00e+00	815.00
IUUC-Ggo-045380	Gorilla gorilla	84.52	0.00e+00	1452.00
IUUC-Hsa-046925	Homo sapiens	84.63	0.00e+00	1430.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	84.19	0.00e+00	1413.00
IUUC-Lch-050325	Latimeria chalumnae	81.59	0.00e+00	889.00
IUUC-Loc-052231	Lepisosteus oculatus	80.25	0.00e+00	849.00
IUUC-Laf-054490	Loxodonta africana	83.04	0.00e+00	1404.00
IUUC-Mcc-055265	Macaca mulatta	83.19	0.00e+00	1436.00
IUUC-Meu-056676	Macropus eugenii	84.27	0.00e+00	728.00
IUUC-Mmr-061633	Microcebus murinus	77.73	0.00e+00	1265.00
IUUC-Mmu-063089	Mus musculus	83.08	0.00e+00	1368.00
IUUC-Mpu-065887	Mustela putorius furo	85.90	0.00e+00	1452.00
IUUC-Mlu-067470	Myotis lucifugus	85.29	0.00e+00	1478.00
IUUC-Nle-069099	Nomascus leucogenys	77.83	0.00e+00	865.00
IUUC-Ont-071613	Oreochromis niloticus	78.46	0.00e+00	815.00
IUUC-Oan-073275	Ornithorhynchus anatinus	88.45	0.00e+00	996.00
IUUC-Ola-087031	Oryzias latipes	71.35	0.00e+00	783.00
IUUC-Oga-088201	Otolemur garnettii	78.14	0.00e+00	1283.00
IUUC-Ptr-091116	Pan troglodytes	84.96	0.00e+00	1476.00
IUUC-Pan-092132	Papio anubis	82.25	0.00e+00	1057.00
IUUC-Psi-093734	Pelodiscus sinensis	87.65	0.00e+00	927.00
IUUC-Pma-094347	Petromyzon marinus	69.61	0.00e+00	687.00
IUUC-Pfo-096293	Poecilia formosa	81.03	0.00e+00	809.00
IUUC-Pab-098491	Pongo abelii	81.23	0.00e+00	1373.00
IUUC-Pca-101004	Procavia capensis	74.89	0.00e+00	820.00
IUUC-Pva-102961	Pteropus vampyrus	64.36	3.00e-153	536.00
IUUC-Rno-105005	Rattus norvegicus	83.62	0.00e+00	1382.00
IUUC-Sha-107646	Sarcophilus harrisii	62.98	0.00e+00	917.00
IUUC-Ssc-115428	Sus scrofa	85.53	0.00e+00	1430.00
IUUC-Tgu-116776	Taeniopygia guttata	89.34	0.00e+00	966.00
IUUC-Tru-118180	Takifugu rubripes	81.74	0.00e+00	803.00
IUUC-Tsy-119468	Tarsius syrichta	74.40	0.00e+00	663.00
IUUC-Tni-120196	Tetraodon nigroviridis	74.47	0.00e+00	796.00
IUUC-Ttr-128360	Tursiops truncatus	83.72	0.00e+00	926.00
IUUC-Xtr-132956	Xenopus tropicalis	72.99	0.00e+00	1206.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence