iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090316

Ensembl Protein ID

ENSOARP00000010470.1

UniProt Accession

W5PJ50; W5PJ50_SHEEP

Genbank Protein ID

ENSOARP00000010470

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01025899

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000009759.1	ENSOART00000010625.1	ENSOARP00000010470.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-69	234.8	681	844

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 175  klvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           + v+e+rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r +
   Q: 681  RMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMR 768
           6799*********************************************************99.************************* PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +LqFvTg++rlP+gGfa+l+    p++f+i+k +++++lP+s+T fn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 769  LLQFVTGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTFFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 844
           **************************************************************************96 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

CPVQVCLPVG DMSGSGSQLG SMGSLTMKSQ LQITVISAKL KENKKNWFGP SPYVEVTVDG 60
QSKKTEKCNN TNSPKWKQPL TVIVTPVSKL HFRVWSHQTL KSDVLLGTAG LDIYETLKSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCCCTGTTC AGGTTTGCCT TCCTGTTGGT GATATGTCTG GCAGTGGATC ACAGCTTGGT 60
TCAATGGGTA GTTTGACCAT GAAATCACAA CTTCAGATCA CTGGTAAGTC TTAAAAACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	81.06	0.00e+00	1269.00
IUUC-Apl-003752	Anas platyrhynchos	69.16	0.00e+00	1115.00
IUUC-Aca-005338	Anolis carolinensis	67.53	0.00e+00	1105.00
IUUC-Bta-012782	Bos taurus	83.29	0.00e+00	1258.00
IUUC-Cja-018899	Callithrix jacchus	77.03	0.00e+00	1202.00
IUUC-Cfa-020648	Canis familiaris	80.09	0.00e+00	1234.00
IUUC-Cpo-022073	Cavia porcellus	80.74	0.00e+00	1284.00
IUUC-Csa-023252	Chlorocebus sabaeus	80.86	0.00e+00	1286.00
IUUC-Cho-024695	Choloepus hoffmanni	74.64	0.00e+00	1261.00
IUUC-Dno-029884	Dasypus novemcinctus	80.16	0.00e+00	1306.00
IUUC-Eca-033793	Equus caballus	81.21	0.00e+00	1301.00
IUUC-Fca-035605	Felis catus	80.90	0.00e+00	1298.00
IUUC-Fal-037126	Ficedula albicollis	69.60	0.00e+00	1117.00
IUUC-Gga-040832	Gallus gallus	68.67	0.00e+00	1132.00
IUUC-Ggo-044535	Gorilla gorilla	77.21	0.00e+00	1259.00
IUUC-Hsa-046564	Homo sapiens	77.41	0.00e+00	1269.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	80.12	0.00e+00	1215.00
IUUC-Lch-050454	Latimeria chalumnae	63.34	0.00e+00	1064.00
IUUC-Laf-054383	Loxodonta africana	81.50	0.00e+00	1296.00
IUUC-Mcc-055532	Macaca mulatta	80.63	0.00e+00	1284.00
IUUC-Mga-059661	Meleagris gallopavo	68.27	0.00e+00	1123.00
IUUC-Mmr-061135	Microcebus murinus	81.09	0.00e+00	1311.00
IUUC-Mdo-062505	Monodelphis domestica	71.27	0.00e+00	1152.00
IUUC-Mmu-063375	Mus musculus	79.28	0.00e+00	1233.00
IUUC-Mpu-066203	Mustela putorius furo	81.17	0.00e+00	1271.00
IUUC-Mlu-067837	Myotis lucifugus	80.76	0.00e+00	1299.00
IUUC-Nle-069244	Nomascus leucogenys	79.63	0.00e+00	1268.00
IUUC-Opr-070585	Ochotona princeps	75.64	0.00e+00	1222.00
IUUC-Ocu-074298	Oryctolagus cuniculus	80.67	0.00e+00	1272.00
IUUC-Oga-088167	Otolemur garnettii	74.39	0.00e+00	1172.00
IUUC-Ptr-090819	Pan troglodytes	76.61	0.00e+00	1231.00
IUUC-Pan-092454	Papio anubis	80.32	0.00e+00	1289.00
IUUC-Psi-093319	Pelodiscus sinensis	68.78	0.00e+00	1105.00
IUUC-Pab-097580	Pongo abelii	70.54	0.00e+00	1105.00
IUUC-Pca-100923	Procavia capensis	68.68	0.00e+00	1135.00
IUUC-Pva-103209	Pteropus vampyrus	80.89	0.00e+00	1247.00
IUUC-Rno-104924	Rattus norvegicus	78.67	0.00e+00	1248.00
IUUC-Sha-107175	Sarcophilus harrisii	72.82	0.00e+00	1147.00
IUUC-Sar-113761	Sorex araneus	70.88	0.00e+00	1130.00
IUUC-Tgu-116632	Taeniopygia guttata	65.96	0.00e+00	997.00
IUUC-Tsy-119198	Tarsius syrichta	80.00	0.00e+00	1300.00
IUUC-Tbe-127756	Tupaia belangeri	62.24	0.00e+00	951.00
IUUC-Ttr-128504	Tursiops truncatus	90.25	0.00e+00	852.00
IUUC-Vpa-130103	Vicugna pacos	67.48	0.00e+00	1045.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence