iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-044829

Ensembl Protein ID

ENSGGOP00000007283.2

UniProt Accession

G3QWW0; G3QWW0_GORGO

Protein Name

Tyrosine-protein kinase

Gene Name

SRC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000007437.2	ENSGGOT00000007475.2	ENSGGOP00000007283.2
ENSGGOG00000007437.2	ENSGGOT00000026168.1	ENSGGOP00000018321.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-12	47.2	88	148

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi....ekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ ++ +L++kkG+ ++++    + +  +++W+ + +  +g+ G +P+n+v+ 
   Q: 88   TFVALYDYESRTETDLSFKKGERLQIVnntrKVDVREGDWWLAHSLSTGQTGYIPSNYVAP 148
           5789***********************64444455689********************975 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MGSNKSKPKD ASQRRRSLEP AENVHGAGGG AFPASQTPSK PASADGHRGP SAAFAPAAAE 60
PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTRKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTAGCA ACAAGAGCAA GCCCAAGGAT GCCAGCCAGC GGCGCCGCAG CCTGGAGCCC 60
GCCGAGAACG TGCACGGCGC TGGCGGGGGC GCTTTCCCCG CCTCGCAGAC CCCCAGCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005901--C:caveola
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0002102--C:podosome
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0020037--F:heme binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0086098--P:angiotensin-activated signaling pathway involved in heart process
GO:0045453--P:bone resorption
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0016477--P:cell migration
GO:0071498--P:cellular response to fluid shear stress
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0034614--P:cellular response to reactive oxygen species
GO:0030900--P:forebrain development
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:2000811--P:negative regulation of anoikis
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0051902--P:negative regulation of mitochondrial depolarization
GO:0032463--P:negative regulation of protein homooligomerization
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0048477--P:oogenesis
GO:0036035--P:osteoclast development
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0010634--P:positive regulation of epithelial cell migration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0071803--P:positive regulation of podosome assembly
GO:0051897--P:positive regulation of protein kinase B signaling
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0010954--P:positive regulation of protein processing
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0051057--P:positive regulation of small GTPase mediated signal transduction
GO:0046777--P:protein autophosphorylation
GO:0031648--P:protein destabilization
GO:2001286--P:regulation of caveolin-mediated endocytosis
GO:0060491--P:regulation of cell projection assembly
GO:0022407--P:regulation of cell-cell adhesion
GO:2000641--P:regulation of early endosome to late endosome transport
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0043393--P:regulation of protein binding
GO:0070555--P:response to interleukin-1
GO:0043149--P:stress fiber assembly
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0060065--P:uterus development

KEGG

ggo:101153251

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	83.76	0.00e+00	897.00
IUUC-Aca-004237	Anolis carolinensis	77.49	0.00e+00	828.00
IUUC-Bta-012982	Bos taurus	82.12	0.00e+00	870.00
IUUC-Cja-019995	Callithrix jacchus	85.61	0.00e+00	915.00
IUUC-Cfa-020060	Canis familiaris	83.76	0.00e+00	895.00
IUUC-Cpo-021557	Cavia porcellus	80.44	0.00e+00	855.00
IUUC-Csa-023711	Chlorocebus sabaeus	85.79	0.00e+00	915.00
IUUC-Dno-029651	Dasypus novemcinctus	80.07	0.00e+00	860.00
IUUC-Ete-033170	Echinops telfairi	82.10	0.00e+00	750.00
IUUC-Eca-033970	Equus caballus	78.12	0.00e+00	799.00
IUUC-Fca-036113	Felis catus	83.76	0.00e+00	895.00
IUUC-Fal-036785	Ficedula albicollis	80.63	0.00e+00	865.00
IUUC-Gga-040899	Gallus gallus	78.78	0.00e+00	842.00
IUUC-Hsa-046192	Homo sapiens	85.98	0.00e+00	917.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	84.69	0.00e+00	892.00
IUUC-Lch-049892	Latimeria chalumnae	72.71	0.00e+00	769.00
IUUC-Laf-053977	Loxodonta africana	84.50	0.00e+00	908.00
IUUC-Mcc-055159	Macaca mulatta	84.09	0.00e+00	906.00
IUUC-Mga-060135	Meleagris gallopavo	80.44	0.00e+00	865.00
IUUC-Mmr-061168	Microcebus murinus	82.64	0.00e+00	894.00
IUUC-Mdo-063030	Monodelphis domestica	78.48	0.00e+00	852.00
IUUC-Mmu-063893	Mus musculus	85.24	0.00e+00	911.00
IUUC-Mpu-066411	Mustela putorius furo	83.76	0.00e+00	895.00
IUUC-Mlu-068139	Myotis lucifugus	83.79	0.00e+00	890.00
IUUC-Nle-070178	Nomascus leucogenys	82.47	0.00e+00	848.00
IUUC-Ocu-074403	Oryctolagus cuniculus	82.35	0.00e+00	869.00
IUUC-Oga-088493	Otolemur garnettii	84.69	0.00e+00	906.00
IUUC-Oar-090279	Ovis aries	82.45	0.00e+00	872.00
IUUC-Ptr-091050	Pan troglodytes	85.98	0.00e+00	917.00
IUUC-Pan-091862	Papio anubis	84.69	0.00e+00	897.00
IUUC-Psi-093071	Pelodiscus sinensis	79.15	0.00e+00	846.00
IUUC-Pab-097902	Pongo abelii	84.09	0.00e+00	907.00
IUUC-Rno-105847	Rattus norvegicus	85.27	0.00e+00	907.00
IUUC-Sha-107539	Sarcophilus harrisii	79.34	0.00e+00	847.00
IUUC-Ssc-115762	Sus scrofa	83.94	0.00e+00	895.00
IUUC-Ttr-128702	Tursiops truncatus	79.34	0.00e+00	831.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence