iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012905

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02054428

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000018921.5	ENSBTAT00000025198.5	ENSBTAP00000025198.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-114	382.1	652	1369

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 652  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 738
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 739  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 823
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 824  FLYLPVPLPQKQKVLPVfyfarephskpikflvsvskenssasevldslsqsvhvkpenlrlaeviknrfhrvflpshsldtvspsd 910
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 911  tllcfellspelakervvvlevqqrpqvpsipiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 997
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 998  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqgpgcttllstssleagdsdrdpiqppelqlvtpvaegdtgasra 1084
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1085 waspdrgpvpstsgissemvasgpvevgaltvgervsrpeaavpgyqhpsealsahtpqffiyridasnreqrledkgdvpldlgdd 1171
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1172 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1258
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldl +fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1259 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLGKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1342
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1343 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1369
           ****************...********996 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

PEPRAGCQGP KRAGGGGGLA RLSVPCWRIC PQRVAKIAGP GRKRRSPDPD VVADPGALWL 60
STKRLKMSGG ASATGPRRGP PGLEEATSKK KQKDRANQES KDGDPRRGGS GIPGAFVAFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAAGCAG CTGAGGTGGT GGCGGCGGCG CCGGGACGGG GGAGGGGCGC GCCGGAACCG 60
GAACCGACCT GACGCCGGAA CCGGAACCGA GAGCGGGTTG CCAAGGCCCG AAGAGGGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	92.41	0.00e+00	2498.00
IUUC-Apl-003368	Anas platyrhynchos	68.12	0.00e+00	1775.00
IUUC-Aca-004267	Anolis carolinensis	68.26	0.00e+00	1667.00
IUUC-Ame-010970	Astyanax mexicanus	69.29	0.00e+00	1343.00
IUUC-Cja-018789	Callithrix jacchus	88.71	0.00e+00	2335.00
IUUC-Cfa-021004	Canis familiaris	92.06	0.00e+00	2514.00
IUUC-Cpo-021529	Cavia porcellus	87.40	0.00e+00	2248.00
IUUC-Csa-024035	Chlorocebus sabaeus	92.44	0.00e+00	2325.00
IUUC-Cho-025036	Choloepus hoffmanni	81.92	0.00e+00	1206.00
IUUC-Cin-025451	Ciona intestinalis	43.93	1.00e-86	314.00
IUUC-Csv-025931	Ciona savignyi	36.73	3.00e-111	395.00
IUUC-Dre-028556	Danio rerio	70.00	0.00e+00	1325.00
IUUC-Dno-029240	Dasypus novemcinctus	91.34	0.00e+00	2092.00
IUUC-Dor-030495	Dipodomys ordii	94.13	0.00e+00	1183.00
IUUC-Ete-032741	Echinops telfairi	91.72	0.00e+00	1856.00
IUUC-Eca-033661	Equus caballus	91.69	0.00e+00	2349.00
IUUC-Eeu-034648	Erinaceus europaeus	91.04	0.00e+00	818.00
IUUC-Fca-035646	Felis catus	91.67	0.00e+00	2474.00
IUUC-Fal-037094	Ficedula albicollis	67.37	0.00e+00	1728.00
IUUC-Gmo-038869	Gadus morhua	71.90	0.00e+00	844.00
IUUC-Gga-041170	Gallus gallus	67.87	0.00e+00	1659.00
IUUC-Gac-041901	Gasterosteus aculeatus	66.70	0.00e+00	1318.00
IUUC-Ggo-044708	Gorilla gorilla	89.84	0.00e+00	2356.00
IUUC-Hsa-046791	Homo sapiens	93.77	0.00e+00	1986.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	89.58	0.00e+00	2263.00
IUUC-Lch-050456	Latimeria chalumnae	52.77	0.00e+00	1176.00
IUUC-Loc-052861	Lepisosteus oculatus	56.95	0.00e+00	1149.00
IUUC-Laf-053788	Loxodonta africana	90.18	0.00e+00	2251.00
IUUC-Mcc-055693	Macaca mulatta	88.87	0.00e+00	2416.00
IUUC-Meu-055921	Macropus eugenii	79.06	0.00e+00	1473.00
IUUC-Mga-059879	Meleagris gallopavo	67.05	0.00e+00	1708.00
IUUC-Mmr-060802	Microcebus murinus	91.33	0.00e+00	2388.00
IUUC-Mdo-061856	Monodelphis domestica	82.63	0.00e+00	1566.00
IUUC-Mmu-063874	Mus musculus	88.08	0.00e+00	2253.00
IUUC-Mpu-066166	Mustela putorius furo	92.08	0.00e+00	2501.00
IUUC-Nle-070161	Nomascus leucogenys	89.54	0.00e+00	2402.00
IUUC-Opr-071015	Ochotona princeps	92.65	0.00e+00	1928.00
IUUC-Ont-072308	Oreochromis niloticus	66.94	0.00e+00	1384.00
IUUC-Oan-072723	Ornithorhynchus anatinus	65.00	0.00e+00	1604.00
IUUC-Ocu-073938	Oryctolagus cuniculus	89.11	0.00e+00	2428.00
IUUC-Ola-086375	Oryzias latipes	69.61	0.00e+00	1357.00
IUUC-Oga-088297	Otolemur garnettii	89.42	0.00e+00	2311.00
IUUC-Oar-089675	Ovis aries	86.19	0.00e+00	2326.00
IUUC-Ptr-091621	Pan troglodytes	93.58	0.00e+00	1981.00
IUUC-Pan-092118	Papio anubis	89.81	0.00e+00	2534.00
IUUC-Pfo-097246	Poecilia formosa	67.50	0.00e+00	1351.00
IUUC-Pab-098551	Pongo abelii	92.62	0.00e+00	1960.00
IUUC-Pca-100158	Procavia capensis	86.20	0.00e+00	2225.00
IUUC-Pva-103160	Pteropus vampyrus	90.49	0.00e+00	2287.00
IUUC-Rno-105355	Rattus norvegicus	88.52	0.00e+00	2293.00
IUUC-Sha-107057	Sarcophilus harrisii	73.19	0.00e+00	1935.00
IUUC-Sar-113011	Sorex araneus	89.40	0.00e+00	1496.00
IUUC-Ssc-115761	Sus scrofa	92.89	0.00e+00	2562.00
IUUC-Tgu-116956	Taeniopygia guttata	64.11	0.00e+00	788.00
IUUC-Tru-118739	Takifugu rubripes	65.84	0.00e+00	1365.00
IUUC-Tsy-118827	Tarsius syrichta	83.19	0.00e+00	1246.00
IUUC-Tni-119921	Tetraodon nigroviridis	61.53	0.00e+00	1404.00
IUUC-Tbe-128017	Tupaia belangeri	91.28	0.00e+00	1915.00
IUUC-Ttr-128869	Tursiops truncatus	92.27	0.00e+00	2305.00
IUUC-Vpa-130427	Vicugna pacos	95.09	0.00e+00	924.00
IUUC-Xtr-132734	Xenopus tropicalis	61.96	0.00e+00	1626.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence