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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045921
UUCD1 version UUC-HoS-00251
Ensembl Protein ID ENSP00000296161.4
UniProt Accession Q8TDB6; B3KWH6; Q53ZZ3; Q5MJP7; DTX3L_HUMAN
Genbank Protein ID AAP57517.1; AAL90859.1; BAG54138.1; AAV98362.1; EAW79476.1; AAH42191.1; AAH60509.1
Protein Name E3 ubiquitin-protein ligase DTX3L; B-lymphoma- and BAL-associated protein; Protein deltex-3-like; RING-type E3 ubiquitin transferase DTX3L; Rhysin-2
Genbank Nucleotide ID AY225123; AF484416; AK125086; AY780792; CH471052; BC042191; BC060509
Gene Name DTX3L; BBAP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163840.9 ENST00000296161.8 ENSP00000296161.4
ENSG00000163840.9 ENST00000383661.3 ENSP00000373157.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16809771
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0006 21.9 561 600
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ +++  +vlp C+H f+a C++k        s + +CP+C+
   Q: 561  CVICMDTISN-KKVLPkCKHEFCAPCINKA------MSYKPICPTCQ 600
           ********88.566777**********888......777777****7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
 Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Protein Sequence
(Fasta)
MASHLRPPSP LLVRVYKSGP RVRRKLESYF QSSKSSGGGE CTVSTQEHEA PGTFRVEFSE 60
RAAKERVLKK GEHQILVDEK PVPIFLVPTE NSIKKNTRPQ ISSLTQSQAE TPSGDMHQHE 120
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Protein Fasta Sequence


>IUUC-Hsa-045921|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
TACTCACCCG GCAGGCCGCT CTCCTCGGTG CAGACAGCAC AGGGAGGAGG GGGAAGCGGC 60
TCTGCCGGGA ACAGGGAGGG ACCTCCAGGG AAGCGAAACT GAAACTTTGC GCCCAGTCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045921|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004088--KH_dom_type_1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006302--P:double-strand break repair
GO:0010390--P:histone monoubiquitination
GO:0000209--P:protein polyubiquitination
KEGG hsa:151636
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001770 Ailuropoda melanoleuca 62.16 0.00e+00 862.00
IUUC-Aca-004465 Anolis carolinensis 36.59 2.00e-120 426.00
IUUC-Ame-011966 Astyanax mexicanus 57.21 1.00e-56 213.00
IUUC-Bta-012460 Bos taurus 64.08 0.00e+00 945.00
IUUC-Cja-019340 Callithrix jacchus 83.65 0.00e+00 1283.00
IUUC-Cfa-020691 Canis familiaris 65.38 0.00e+00 949.00
IUUC-Cpo-021781 Cavia porcellus 61.43 0.00e+00 892.00
IUUC-Csa-024106 Chlorocebus sabaeus 90.68 0.00e+00 1361.00
IUUC-Cho-024817 Choloepus hoffmanni 70.31 0.00e+00 980.00
IUUC-Cin-025746 Ciona intestinalis 54.40 4.00e-60 226.00
IUUC-Csv-025973 Ciona savignyi 48.89 6.00e-46 176.00
IUUC-Dre-028024 Danio rerio 37.86 7.00e-66 245.00
IUUC-Dno-028880 Dasypus novemcinctus 70.55 0.00e+00 1026.00
IUUC-Dor-030737 Dipodomys ordii 60.36 0.00e+00 838.00
IUUC-Ete-033015 Echinops telfairi 58.47 1.00e-109 390.00
IUUC-Eca-034086 Equus caballus 69.25 0.00e+00 973.00
IUUC-Eeu-034446 Erinaceus europaeus 61.31 0.00e+00 726.00
IUUC-Fca-036218 Felis catus 67.88 0.00e+00 1005.00
IUUC-Fal-036797 Ficedula albicollis 35.77 3.00e-122 432.00
IUUC-Gmo-039104 Gadus morhua 58.85 4.00e-61 227.00
IUUC-Gga-041219 Gallus gallus 37.04 2.00e-122 432.00
IUUC-Ggo-044786 Gorilla gorilla 98.92 0.00e+00 1516.00
IUUC-Itr-047911 Ictidomys tridecemlineatus 69.73 0.00e+00 1029.00
IUUC-Loc-052602 Lepisosteus oculatus 32.32 7.00e-73 268.00
IUUC-Laf-054092 Loxodonta africana 65.60 0.00e+00 950.00
IUUC-Meu-056309 Macropus eugenii 48.36 3.00e-155 542.00
IUUC-Mga-059221 Meleagris gallopavo 37.21 8.00e-114 404.00
IUUC-Mmr-061722 Microcebus murinus 73.82 0.00e+00 1068.00
IUUC-Mdo-062897 Monodelphis domestica 45.85 3.00e-169 588.00
IUUC-Mmu-063310 Mus musculus 57.48 0.00e+00 808.00
IUUC-Mpu-065715 Mustela putorius furo 65.33 0.00e+00 949.00
IUUC-Mlu-068125 Myotis lucifugus 65.74 5.00e-85 306.00
IUUC-Opr-070573 Ochotona princeps 59.68 0.00e+00 823.00
IUUC-Ont-071389 Oreochromis niloticus 55.77 4.00e-64 237.00
IUUC-Ocu-074404 Oryctolagus cuniculus 65.66 0.00e+00 977.00
IUUC-Ola-087174 Oryzias latipes 54.60 4.00e-51 193.00
IUUC-Oga-088174 Otolemur garnettii 71.52 0.00e+00 909.00
IUUC-Oar-089488 Ovis aries 64.48 0.00e+00 875.00
IUUC-Ptr-091454 Pan troglodytes 99.19 0.00e+00 1521.00
IUUC-Pan-092016 Papio anubis 91.22 0.00e+00 1370.00
IUUC-Psi-093616 Pelodiscus sinensis 42.78 2.00e-109 389.00
IUUC-Pfo-096350 Poecilia formosa 59.04 6.00e-58 218.00
IUUC-Pab-098106 Pongo abelii 91.35 0.00e+00 1382.00
IUUC-Pva-103155 Pteropus vampyrus 65.84 0.00e+00 892.00
IUUC-Pgr-103282 Puccinia graminis 38.33 2.00e-07 49.70
IUUC-Rno-105277 Rattus norvegicus 57.73 0.00e+00 843.00
IUUC-Sha-107310 Sarcophilus harrisii 46.35 3.00e-175 608.00
IUUC-Smo-108775 Selaginella moellendorffii 46.45 4.00e-45 174.00
IUUC-Sar-113237 Sorex araneus 59.29 1.00e-140 493.00
IUUC-Ssc-115952 Sus scrofa 56.19 0.00e+00 786.00
IUUC-Tgu-117018 Taeniopygia guttata 39.81 2.00e-118 420.00
IUUC-Tsy-119396 Tarsius syrichta 71.88 0.00e+00 735.00
IUUC-Tbe-127250 Tupaia belangeri 69.35 0.00e+00 821.00
IUUC-Ttr-128283 Tursiops truncatus 67.65 0.00e+00 997.00
IUUC-Vpa-130042 Vicugna pacos 61.90 0.00e+00 773.00
Created Date 25-Jun-2017

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