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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045716
UUCD1 version UUC-HoS-00198
Ensembl Protein ID ENSP00000322885.5
UniProt Accession Q86UW9; Q6XM87; Q6XM88; Q96H69; Q9H890; Q9P200; DTX2_HUMAN
Genbank Protein ID AAP57518.1; AAP57519.1; BAA96052.1; BAB14727.1; AAP21881.1; AAH08856.1; AAH18555.1; AAH26059.1; AAH93079.1
Protein Name Probable E3 ubiquitin-protein ligase DTX2; Protein deltex-2; RING finger protein 58; RING-type E3 ubiquitin transferase DTX2
Genbank Nucleotide ID AY225124; AY225125; AB040961; AK023924; AC005522; AC007078; BC018555; BC026059; BC093079
Gene Name DTX2; KIAA1528; RNF58
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000091073.19 ENST00000324432.9 ENSP00000322885.5
ENSG00000091073.19 ENST00000446820.6 ENSP00000392545.2
ENSG00000091073.19 ENST00000435251.2 ENSP00000410892.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircRNADbCircNetmiRTarBase
microRNATRANSFACmiRWalkRepTar
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 12670957
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.00e-05 27.6 412 473
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf...........kdg.......plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+e +           +          +++ C H+fh+ Cl ++ + + ++ ++ +CP C+
   Q: 412  CIICMEKLstasgysdvtdS-KaigslavGHLTKCSHAFHLLCLLAM-YCNGNKDGSLQCPSCK 473
           ******99666655444330.0333333366899**********888.89999**********6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
 S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
Protein Sequence
(Fasta)
MAMAPSPSLV QVYTSPAAVA VWEWQDGLGT WHPYSATVCS FIEQQFVQQK GQRFGLGSLA 60
HSIPLGQADP SLAPYIIDLP SWTQFRQDTG TMRAVRRHLF PQHSAPGRGV VWEWLSDDGS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045716|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGCGCAGCG GCTCGCTCGG AAGCTGCGAC GCCGAGTTTC ACTCTGGCTG CCTTCTCCTG 60
AGAGTCGGAG CCACAGCCAG AGCCCTGCCC AGGCCGAGCC GGAGCTGCAG CCCGAGCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045716|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0488--Methylation
KW-0914--Notch signaling pathway
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50918--WWE
PS50089--ZF_RING_2
Pfam

PF02825--WWE
PF00097--zf-C3HC4
SMART

SM00184--RING
SM00678--WWE
Gene Ontology

GO:0005737--C:cytoplasm
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0016567--P:protein ubiquitination
KEGG hsa:113878
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000681 Aegilops tauschii 35.82 2.00e-05 44.70
IUUC-Aml-001936 Ailuropoda melanoleuca 91.00 0.00e+00 1096.00
IUUC-Atr-002866 Amborella trichopoda 31.63 1.00e-04 41.60
IUUC-Apl-003758 Anas platyrhynchos 58.73 0.00e+00 665.00
IUUC-Aca-004841 Anolis carolinensis 51.10 2.00e-130 459.00
IUUC-Aor-010238 Aspergillus oryzae 31.03 2.00e-03 35.40
IUUC-Ame-011200 Astyanax mexicanus 65.02 5.00e-111 395.00
IUUC-Cja-018934 Callithrix jacchus 93.90 0.00e+00 1115.00
IUUC-Cfa-020925 Canis familiaris 87.80 0.00e+00 1086.00
IUUC-Cpo-021609 Cavia porcellus 88.10 0.00e+00 1061.00
IUUC-Csa-023891 Chlorocebus sabaeus 95.18 0.00e+00 1186.00
IUUC-Dno-029480 Dasypus novemcinctus 88.42 0.00e+00 1059.00
IUUC-Dor-031138 Dipodomys ordii 87.78 0.00e+00 1050.00
IUUC-Ete-032479 Echinops telfairi 88.33 2.00e-136 479.00
IUUC-Eca-034342 Equus caballus 90.53 0.00e+00 1097.00
IUUC-Eeu-034455 Erinaceus europaeus 86.19 2.00e-108 386.00
IUUC-Fca-036373 Felis catus 92.77 0.00e+00 1109.00
IUUC-Fal-037532 Ficedula albicollis 70.23 8.00e-123 434.00
IUUC-Ggo-045222 Gorilla gorilla 85.96 0.00e+00 1047.00
IUUC-Itr-048253 Ictidomys tridecemlineatus 91.49 0.00e+00 1101.00
IUUC-Lch-050520 Latimeria chalumnae 54.52 3.00e-170 592.00
IUUC-Lpe-051456 Leersia perrieri 36.51 2.00e-05 44.30
IUUC-Laf-054290 Loxodonta africana 89.23 0.00e+00 1082.00
IUUC-Mcc-054636 Macaca mulatta 96.30 0.00e+00 1169.00
IUUC-Meu-056652 Macropus eugenii 72.76 1.00e-118 420.00
IUUC-Mga-059841 Meleagris gallopavo 60.92 0.00e+00 691.00
IUUC-Mmr-060582 Microcebus murinus 91.96 0.00e+00 1101.00
IUUC-Mdo-062910 Monodelphis domestica 68.17 0.00e+00 822.00
IUUC-Mmu-063723 Mus musculus 84.11 0.00e+00 1009.00
IUUC-Mac-065583 Musa acuminata 30.77 6.00e-05 40.40
IUUC-Mpu-066817 Mustela putorius furo 83.44 0.00e+00 1010.00
IUUC-Mlu-067955 Myotis lucifugus 87.30 0.00e+00 1058.00
IUUC-Ncr-068812 Neurospora crassa 29.17 3.00e-02 32.30
IUUC-Nle-069055 Nomascus leucogenys 96.11 0.00e+00 720.00
IUUC-Opr-070290 Ochotona princeps 89.82 7.00e-155 540.00
IUUC-Oan-073083 Ornithorhynchus anatinus 57.73 1.00e-162 566.00
IUUC-Ocu-074325 Oryctolagus cuniculus 88.28 0.00e+00 1091.00
IUUC-Oba-075059 Oryza barthii 38.71 6.00e-05 42.40
IUUC-Obr-076780 Oryza brachyantha 37.10 3.00e-05 43.50
IUUC-Ogl-077648 Oryza glaberrima 35.82 7.00e-05 42.40
IUUC-Ogu-078365 Oryza glumaepatula 38.71 4.00e-05 43.10
IUUC-Oin-079914 Oryza indica 38.71 6.00e-05 42.40
IUUC-Olo-080385 Oryza longistaminata 35.82 7.00e-05 42.40
IUUC-Oni-083039 Oryza nivara 38.71 6.00e-05 42.40
IUUC-Opu-083889 Oryza punctata 38.71 4.00e-05 43.50
IUUC-Oru-084419 Oryza rufipogon 38.71 6.00e-05 42.40
IUUC-Osa-085535 Oryza sativa 38.71 6.00e-05 42.40
IUUC-Ola-087563 Oryzias latipes 43.69 4.00e-126 445.00
IUUC-Oga-088806 Otolemur garnettii 89.25 0.00e+00 1081.00
IUUC-Oar-089906 Ovis aries 85.69 0.00e+00 887.00
IUUC-Ptr-090683 Pan troglodytes 98.55 0.00e+00 1214.00
IUUC-Pan-092356 Papio anubis 95.82 0.00e+00 1161.00
IUUC-Psi-093479 Pelodiscus sinensis 63.10 0.00e+00 754.00
IUUC-Pfo-097482 Poecilia formosa 57.19 1.00e-100 360.00
IUUC-Pab-098412 Pongo abelii 96.46 0.00e+00 1201.00
IUUC-Pca-100995 Procavia capensis 68.24 7.00e-86 311.00
IUUC-Pva-103068 Pteropus vampyrus 78.69 0.00e+00 917.00
IUUC-Pte-104268 Pyrenophora teres 32.81 2.00e-03 35.80
IUUC-Rno-105159 Rattus norvegicus 84.43 0.00e+00 1004.00
IUUC-Sha-107480 Sarcophilus harrisii 74.15 8.00e-164 569.00
IUUC-Sar-113689 Sorex araneus 74.64 0.00e+00 915.00
IUUC-Ssc-115373 Sus scrofa 92.28 2.00e-156 544.00
IUUC-Tgu-117036 Taeniopygia guttata 63.59 0.00e+00 756.00
IUUC-Tru-118461 Takifugu rubripes 64.05 2.00e-103 370.00
IUUC-Tsy-118930 Tarsius syrichta 86.29 3.00e-134 472.00
IUUC-Tni-120383 Tetraodon nigroviridis 50.24 8.00e-155 540.00
IUUC-Tae-125082 Triticum aestivum 35.82 1.00e-05 44.70
IUUC-Tur-126364 Triticum urartu 38.71 2.00e-05 44.30
IUUC-Tbe-127561 Tupaia belangeri 90.51 0.00e+00 1046.00
IUUC-Ttr-128688 Tursiops truncatus 79.76 5.00e-178 617.00
IUUC-Xtr-132053 Xenopus tropicalis 51.26 6.00e-171 594.00
Created Date 25-Jun-2017

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