iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053644

UUCD1 version

UUC-LoA-00875

Ensembl Protein ID

ENSLAFP00000025494.1

UniProt Accession

G3UCD6; G3UCD6_LOXAF

Protein Name

Uncharacterized protein

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000012470.3	ENSLAFT00000031921.1	ENSLAFP00000025494.1
ENSLAFG00000012470.3	ENSLAFT00000012472.3	ENSLAFP00000010422.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.80e-127	424.3	407	739

Active Site

Position(s)	Description	Evidence
708	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 407  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 494
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk ++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 495  GFTVPFYKQLLGKAIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHSAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 579
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e+f++e r+++LqFv
   Q: 580  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVEAFDEERRARLLQFV 667
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 668  TGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 739
           ***************************99999**************************************76 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

VLCAKNLAKK DFFRLPDPFA KIVVDGSGQC HSTDTVKNTL DPKWNQHYDL YVGKTDSITL 60
SVWNHKKIHK KQGAGFLGCV RLLSNAISRL KDTGYQRLDL CKLNPSDTDA VRGQIVVSLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATTATGTG CCAAGAATCT TGCAAAGAAA GACTTCTTCA GTAAGTAAAC ATCCATTTTT 60
TGCCATCTTC CAATATTATT ATTCTTCACT TATTTATGAA ATTTGAAACT TTTTAAGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	93.40	0.00e+00	1413.00
IUUC-Apl-004155	Anas platyrhynchos	89.69	0.00e+00	1394.00
IUUC-Aca-005238	Anolis carolinensis	91.52	0.00e+00	1403.00
IUUC-Ame-010901	Astyanax mexicanus	86.02	0.00e+00	1313.00
IUUC-Bta-013221	Bos taurus	92.29	0.00e+00	1350.00
IUUC-Cja-018985	Callithrix jacchus	90.77	0.00e+00	1424.00
IUUC-Cfa-020568	Canis familiaris	90.51	0.00e+00	1401.00
IUUC-Cpo-022531	Cavia porcellus	90.25	0.00e+00	1414.00
IUUC-Csa-024145	Chlorocebus sabaeus	94.05	0.00e+00	1439.00
IUUC-Cho-024963	Choloepus hoffmanni	73.72	0.00e+00	905.00
IUUC-Dre-028341	Danio rerio	86.31	0.00e+00	1322.00
IUUC-Dno-029705	Dasypus novemcinctus	90.25	0.00e+00	1393.00
IUUC-Eca-034125	Equus caballus	90.51	0.00e+00	1417.00
IUUC-Fca-035905	Felis catus	93.41	0.00e+00	1412.00
IUUC-Fal-037336	Ficedula albicollis	92.32	0.00e+00	1392.00
IUUC-Gmo-039486	Gadus morhua	79.73	0.00e+00	857.00
IUUC-Gga-040218	Gallus gallus	90.99	0.00e+00	1400.00
IUUC-Gac-041707	Gasterosteus aculeatus	80.16	0.00e+00	1212.00
IUUC-Ggo-045408	Gorilla gorilla	84.92	0.00e+00	1311.00
IUUC-Hsa-045878	Homo sapiens	90.64	0.00e+00	1422.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	90.76	0.00e+00	1421.00
IUUC-Loc-052628	Lepisosteus oculatus	84.75	0.00e+00	1320.00
IUUC-Mcc-055479	Macaca mulatta	85.73	0.00e+00	1275.00
IUUC-Mga-059723	Meleagris gallopavo	92.08	0.00e+00	1397.00
IUUC-Mdo-063005	Monodelphis domestica	92.73	0.00e+00	1419.00
IUUC-Mmu-063634	Mus musculus	93.41	0.00e+00	1405.00
IUUC-Mpu-065898	Mustela putorius furo	93.41	0.00e+00	1414.00
IUUC-Mlu-067584	Myotis lucifugus	90.25	0.00e+00	1416.00
IUUC-Nle-069033	Nomascus leucogenys	90.64	0.00e+00	1422.00
IUUC-Ont-072265	Oreochromis niloticus	79.04	0.00e+00	1226.00
IUUC-Oan-073621	Ornithorhynchus anatinus	92.51	0.00e+00	1425.00
IUUC-Ocu-073960	Oryctolagus cuniculus	89.34	0.00e+00	1384.00
IUUC-Oga-088579	Otolemur garnettii	90.64	0.00e+00	1420.00
IUUC-Oar-090396	Ovis aries	88.43	0.00e+00	1313.00
IUUC-Ptr-091624	Pan troglodytes	90.64	0.00e+00	1422.00
IUUC-Pan-092479	Papio anubis	90.51	0.00e+00	1420.00
IUUC-Pfo-097203	Poecilia formosa	80.91	0.00e+00	1241.00
IUUC-Pab-097540	Pongo abelii	90.08	0.00e+00	1350.00
IUUC-Pca-100379	Procavia capensis	72.94	0.00e+00	640.00
IUUC-Rno-105396	Rattus norvegicus	93.41	0.00e+00	1407.00
IUUC-Sha-107216	Sarcophilus harrisii	89.60	0.00e+00	1406.00
IUUC-Ssc-116413	Sus scrofa	92.46	0.00e+00	1381.00
IUUC-Tgu-116723	Taeniopygia guttata	88.47	0.00e+00	1370.00
IUUC-Tru-117843	Takifugu rubripes	81.37	0.00e+00	1244.00
IUUC-Tsy-119455	Tarsius syrichta	89.95	0.00e+00	1325.00
IUUC-Tni-120829	Tetraodon nigroviridis	78.91	0.00e+00	1184.00
IUUC-Tbe-127879	Tupaia belangeri	77.39	0.00e+00	1156.00
IUUC-Ttr-128423	Tursiops truncatus	89.06	0.00e+00	1335.00
IUUC-Xtr-132237	Xenopus tropicalis	83.33	0.00e+00	1312.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence