iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013272

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF170; RING finger protein 170; RING-type E3 ubiquitin transferase RNF170

Genbank Nucleotide ID

DAAA02060959

Gene Name

RNF170

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000007630.5	ENSBTAT00000047188.3	ENSBTAP00000044412.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.50e-06	26.7	88	131

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskef....rCPlCr 46
           C+iCl   +  p+ ++CgH+f+ +C+   w       ++++    +CP+Cr
   Q: 88   CPICLHQASL-PVETNCGHLFCGTCIvAYW------RYGSWlgaiSCPICR 131
           ****998888.999************6666......5555533337****8 PP

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase. Plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells.

Protein Sequence
(Fasta)

MAKYQGEVQS LKLDDDSVIE GVSDQVLVAV VVSLALIATL VYALFSRNAH QNIHPENQEL 60
VRVLREQLQT EQDAPAAARQ QFYTDMYCPI CLHQASLPVE TNCGHLFCGT CIVAYWRYGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCAAAT ATCAAGGTGA AGTTCAAAGT TTGAAACTGG ATGATGATTC AGTCATAGAA 60
GGAGTAAGTG ACCAAGTACT CGTGGCGGTT GTGGTCAGTC TCGCTTTGAT TGCTACCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR010652--DUF1232
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF06803--DUF1232
PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000837	Aegilops tauschii	35.98	4.00e-23	100.00
IUUC-Aml-002276	Ailuropoda melanoleuca	96.14	2.00e-122	431.00
IUUC-Atr-003163	Amborella trichopoda	38.07	2.00e-29	122.00
IUUC-Apl-003771	Anas platyrhynchos	75.68	2.00e-94	338.00
IUUC-Aca-004706	Anolis carolinensis	74.52	5.00e-90	323.00
IUUC-Aly-006202	Arabidopsis lyrata	40.19	7.00e-20	90.10
IUUC-Ath-007325	Arabidopsis thaliana	35.67	1.00e-25	109.00
IUUC-Ame-011453	Astyanax mexicanus	68.60	8.00e-92	329.00
IUUC-Bdi-014259	Brachypodium distachyon	35.43	7.00e-26	110.00
IUUC-Bol-016302	Brassica oleracea	34.91	3.00e-26	111.00
IUUC-Bra-017738	Brassica rapa	34.91	7.00e-26	109.00
IUUC-Cel-018593	Caenorhabditis elegans	34.34	8.00e-28	117.00
IUUC-Cja-019253	Callithrix jacchus	95.37	5.00e-120	423.00
IUUC-Cfa-020844	Canis familiaris	97.29	1.00e-122	433.00
IUUC-Cpo-021645	Cavia porcellus	93.05	4.00e-118	416.00
IUUC-Csa-024012	Chlorocebus sabaeus	95.75	8.00e-121	426.00
IUUC-Cho-024304	Choloepus hoffmanni	75.29	4.00e-86	310.00
IUUC-Cin-025256	Ciona intestinalis	45.56	2.00e-54	205.00
IUUC-Dre-028166	Danio rerio	69.72	1.00e-80	292.00
IUUC-Dno-029494	Dasypus novemcinctus	95.75	1.00e-120	425.00
IUUC-Dor-030259	Dipodomys ordii	93.05	4.00e-117	414.00
IUUC-Ete-032614	Echinops telfairi	82.63	3.00e-96	344.00
IUUC-Eca-033557	Equus caballus	94.59	4.00e-119	420.00
IUUC-Eeu-035324	Erinaceus europaeus	100.00	9.00e-32	130.00
IUUC-Fca-035812	Felis catus	96.53	9.00e-122	429.00
IUUC-Fal-036654	Ficedula albicollis	79.92	6.00e-103	367.00
IUUC-Gmo-039635	Gadus morhua	67.82	2.00e-92	331.00
IUUC-Gga-040345	Gallus gallus	79.15	4.00e-102	363.00
IUUC-Gac-041668	Gasterosteus aculeatus	66.03	1.00e-88	319.00
IUUC-Gma-043890	Glycine max	31.98	3.00e-26	110.00
IUUC-Ggo-045000	Gorilla gorilla	95.75	8.00e-121	426.00
IUUC-Hsa-046691	Homo sapiens	94.98	6.00e-120	423.00
IUUC-Hvu-047464	Hordeum vulgare	35.43	3.00e-26	110.00
IUUC-Itr-048988	Ictidomys tridecemlineatus	94.59	4.00e-120	423.00
IUUC-Lch-049846	Latimeria chalumnae	80.34	9.00e-62	229.00
IUUC-Loc-051785	Lepisosteus oculatus	69.70	1.00e-104	372.00
IUUC-Laf-054542	Loxodonta africana	91.12	7.00e-114	402.00
IUUC-Mcc-055234	Macaca mulatta	95.75	8.00e-121	426.00
IUUC-Meu-056544	Macropus eugenii	69.88	9.00e-74	269.00
IUUC-Mtr-057996	Medicago truncatula	32.99	1.00e-18	86.30
IUUC-Mmr-060609	Microcebus murinus	93.05	4.00e-121	427.00
IUUC-Mdo-062853	Monodelphis domestica	88.03	1.00e-113	401.00
IUUC-Mmu-064383	Mus musculus	88.03	6.00e-106	376.00
IUUC-Mac-065250	Musa acuminata	37.57	4.00e-28	117.00
IUUC-Mlu-067410	Myotis lucifugus	96.91	5.00e-123	433.00
IUUC-Nle-069537	Nomascus leucogenys	94.83	6.00e-82	295.00
IUUC-Opr-070637	Ochotona princeps	92.67	5.00e-64	238.00
IUUC-Ont-071800	Oreochromis niloticus	71.11	8.00e-86	309.00
IUUC-Oan-073190	Ornithorhynchus anatinus	87.64	3.00e-114	404.00
IUUC-Ocu-073899	Oryctolagus cuniculus	94.21	3.00e-118	417.00
IUUC-Obr-076075	Oryza brachyantha	35.58	1.00e-24	105.00
IUUC-Oin-079850	Oryza indica	35.21	8.00e-25	106.00
IUUC-Ome-081191	Oryza meridionalis	35.92	4.00e-24	103.00
IUUC-Oni-082886	Oryza nivara	35.21	7.00e-25	106.00
IUUC-Osa-085833	Oryza sativa	35.21	8.00e-25	106.00
IUUC-Ola-086372	Oryzias latipes	69.08	1.00e-88	319.00
IUUC-Oga-087988	Otolemur garnettii	94.21	8.00e-117	412.00
IUUC-Oar-089976	Ovis aries	98.46	1.00e-126	445.00
IUUC-Ptr-091377	Pan troglodytes	96.14	5.00e-121	426.00
IUUC-Pan-092348	Papio anubis	95.37	5.00e-120	423.00
IUUC-Psi-092982	Pelodiscus sinensis	78.76	5.00e-96	343.00
IUUC-Ppa-095627	Physcomitrella patens	37.87	5.00e-23	101.00
IUUC-Pfo-096366	Poecilia formosa	67.56	4.00e-88	317.00
IUUC-Pab-098242	Pongo abelii	94.86	1.00e-105	375.00
IUUC-Pop-099622	Populus trichocarpa	28.79	3.00e-22	98.20
IUUC-Pca-100637	Procavia capensis	100.00	5.00e-31	127.00
IUUC-Ppe-101586	Prunus persica	34.09	2.00e-16	77.40
IUUC-Pva-102627	Pteropus vampyrus	96.14	2.00e-125	441.00
IUUC-Rno-105344	Rattus norvegicus	88.03	5.00e-110	390.00
IUUC-Sha-107420	Sarcophilus harrisii	86.92	1.00e-111	395.00
IUUC-Smo-109218	Selaginella moellendorffii	34.30	5.00e-27	113.00
IUUC-Sly-111612	Solanum lycopersicum	32.86	2.00e-19	89.40
IUUC-Stu-112127	Solanum tuberosum	35.75	2.00e-22	98.20
IUUC-Sar-113762	Sorex araneus	95.37	8.00e-121	426.00
IUUC-Sbi-113997	Sorghum bicolor	33.91	2.00e-24	105.00
IUUC-Ssc-115764	Sus scrofa	100.00	9.00e-31	124.00
IUUC-Tgu-116969	Taeniopygia guttata	80.31	1.00e-103	368.00
IUUC-Tru-118414	Takifugu rubripes	73.30	1.00e-82	298.00
IUUC-Tsy-119312	Tarsius syrichta	84.94	1.00e-111	395.00
IUUC-Tni-120687	Tetraodon nigroviridis	71.43	1.00e-84	305.00
IUUC-Tca-121028	Theobroma cacao	36.21	5.00e-19	87.00
IUUC-Tae-122873	Triticum aestivum	37.06	1.00e-25	108.00
IUUC-Tur-126558	Triticum urartu	35.10	8.00e-20	89.40
IUUC-Tbe-127751	Tupaia belangeri	86.49	6.00e-100	357.00
IUUC-Ttr-128731	Tursiops truncatus	87.26	2.00e-108	385.00
IUUC-Vpa-130187	Vicugna pacos	96.91	7.00e-122	429.00
IUUC-Vvi-131393	Vitis vinifera	36.63	2.00e-25	108.00
IUUC-Xtr-132512	Xenopus tropicalis	69.11	1.00e-90	326.00
IUUC-Xma-133203	Xiphophorus maculatus	67.18	1.00e-87	316.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence