iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-116865

Ensembl Protein ID

ENSTGUP00000011433.1

UniProt Accession

H0ZLG0; H0ZLG0_TAEGU

Genbank Protein ID

ENSTGUP00000011433

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ABQF01005175

Gene Name

LYN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000011056.1	ENSTGUT00000011557.1	ENSTGUP00000011433.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.60e-16	59.8	68	123

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v +ly+y++ ++++L++kkG++++vi   e++++W+++++ ++ k+G++P+n+v+k++
   Q: 68   IVVALYPYDGIHEEDLSFKKGEKLKVI---EESGEWWRAKSLTTRKEGFIPSNYVAKVN 123
           5899***********************...99*************************97 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MGCIKSKRKE NLHGDGLDLK NQPVRKTERT IYVRDPTSNK QQRPGNPEAQ LLPGQRFVNQ 60
DAEEQGVIVV ALYPYDGIHE EDLSFKKGEK LKVIEESGEW WRAKSLTTRK EGFIPSNYVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGTGTA TAAAATCAAA AAGGAAAGAG AATCTGCATG GAGATGGGCT AGATTTGAAG 60
AATCAACCAG TACGTAAAAC TGAACGAACT ATTTATGTGA GGGATCCAAC GTCCAATAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0001782--P:B cell homeostasis
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0097028--P:dendritic cell differentiation
GO:0030218--P:erythrocyte differentiation
GO:0002774--P:Fc receptor mediated inhibitory signaling pathway
GO:0002431--P:Fc receptor mediated stimulatory signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0031663--P:lipopolysaccharide-mediated signaling pathway
GO:0030889--P:negative regulation of B cell proliferation
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043407--P:negative regulation of MAP kinase activity
GO:0070667--P:negative regulation of mast cell proliferation
GO:0002762--P:negative regulation of myeloid leukocyte differentiation
GO:0034136--P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144--P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175--P:neuron projection development
GO:0002576--P:platelet degranulation
GO:0050861--P:positive regulation of B cell receptor signaling pathway
GO:0030335--P:positive regulation of cell migration
GO:2000670--P:positive regulation of dendritic cell apoptotic process
GO:0070668--P:positive regulation of mast cell proliferation
GO:0010976--P:positive regulation of neuron projection development
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304--P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0046777--P:protein autophosphorylation
GO:0002902--P:regulation of B cell apoptotic process
GO:0033628--P:regulation of cell adhesion mediated by integrin
GO:0050707--P:regulation of cytokine secretion
GO:0045646--P:regulation of erythrocyte differentiation
GO:0050727--P:regulation of inflammatory response
GO:0043304--P:regulation of mast cell degranulation
GO:0090025--P:regulation of monocyte chemotaxis
GO:0090330--P:regulation of platelet aggregation
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0009725--P:response to hormone
GO:0002513--P:tolerance induction to self antigen
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001812	Ailuropoda melanoleuca	89.47	0.00e+00	964.00
IUUC-Apl-004139	Anas platyrhynchos	94.97	0.00e+00	1019.00
IUUC-Aca-004333	Anolis carolinensis	88.93	0.00e+00	951.00
IUUC-Ame-011257	Astyanax mexicanus	78.14	0.00e+00	839.00
IUUC-Bta-013257	Bos taurus	88.69	0.00e+00	958.00
IUUC-Cja-018827	Callithrix jacchus	88.50	0.00e+00	953.00
IUUC-Cfa-020816	Canis familiaris	89.28	0.00e+00	961.00
IUUC-Cpo-021423	Cavia porcellus	89.08	0.00e+00	958.00
IUUC-Csa-024244	Chlorocebus sabaeus	88.69	0.00e+00	952.00
IUUC-Dre-028518	Danio rerio	78.25	0.00e+00	828.00
IUUC-Dno-029322	Dasypus novemcinctus	89.28	0.00e+00	957.00
IUUC-Dor-030706	Dipodomys ordii	79.34	0.00e+00	837.00
IUUC-Eca-034193	Equus caballus	89.86	0.00e+00	969.00
IUUC-Eeu-035004	Erinaceus europaeus	62.73	4.00e-143	500.00
IUUC-Fal-037273	Ficedula albicollis	99.22	0.00e+00	1061.00
IUUC-Gmo-039677	Gadus morhua	75.11	0.00e+00	728.00
IUUC-Gga-040417	Gallus gallus	91.62	0.00e+00	975.00
IUUC-Gac-042490	Gasterosteus aculeatus	70.54	0.00e+00	778.00
IUUC-Ggo-045096	Gorilla gorilla	88.69	0.00e+00	954.00
IUUC-Hsa-046214	Homo sapiens	88.69	0.00e+00	954.00
IUUC-Itr-048354	Ictidomys tridecemlineatus	89.67	0.00e+00	966.00
IUUC-Lch-049991	Latimeria chalumnae	81.94	0.00e+00	868.00
IUUC-Loc-052309	Lepisosteus oculatus	79.46	0.00e+00	853.00
IUUC-Laf-053568	Loxodonta africana	89.08	0.00e+00	959.00
IUUC-Mcc-054849	Macaca mulatta	88.69	0.00e+00	952.00
IUUC-Meu-056170	Macropus eugenii	74.27	0.00e+00	765.00
IUUC-Mmr-061519	Microcebus murinus	88.69	0.00e+00	957.00
IUUC-Mdo-062090	Monodelphis domestica	77.97	0.00e+00	852.00
IUUC-Mmu-063760	Mus musculus	89.28	0.00e+00	956.00
IUUC-Mpu-065677	Mustela putorius furo	89.67	0.00e+00	967.00
IUUC-Mlu-067386	Myotis lucifugus	89.47	0.00e+00	965.00
IUUC-Nle-069742	Nomascus leucogenys	88.69	0.00e+00	954.00
IUUC-Ont-071537	Oreochromis niloticus	73.31	0.00e+00	793.00
IUUC-Oan-073193	Ornithorhynchus anatinus	88.33	0.00e+00	954.00
IUUC-Ocu-074501	Oryctolagus cuniculus	89.47	0.00e+00	963.00
IUUC-Ogu-078119	Oryza glumaepatula	35.68	2.00e-21	96.70
IUUC-Ola-086726	Oryzias latipes	70.43	0.00e+00	775.00
IUUC-Oga-088069	Otolemur garnettii	88.16	0.00e+00	952.00
IUUC-Oar-090091	Ovis aries	88.69	0.00e+00	957.00
IUUC-Ptr-091409	Pan troglodytes	88.69	0.00e+00	954.00
IUUC-Pan-092268	Papio anubis	88.69	0.00e+00	954.00
IUUC-Psi-093685	Pelodiscus sinensis	91.70	0.00e+00	980.00
IUUC-Pfo-096217	Poecilia formosa	73.40	0.00e+00	802.00
IUUC-Pab-098601	Pongo abelii	88.69	0.00e+00	954.00
IUUC-Pva-102160	Pteropus vampyrus	78.21	0.00e+00	821.00
IUUC-Rno-105557	Rattus norvegicus	89.47	0.00e+00	964.00
IUUC-Sha-106643	Sarcophilus harrisii	88.33	0.00e+00	949.00
IUUC-Sar-113555	Sorex araneus	87.54	2.00e-161	561.00
IUUC-Ssc-116317	Sus scrofa	82.88	0.00e+00	882.00
IUUC-Tru-118284	Takifugu rubripes	71.60	0.00e+00	788.00
IUUC-Tsy-119440	Tarsius syrichta	85.19	0.00e+00	908.00
IUUC-Tni-120005	Tetraodon nigroviridis	70.35	0.00e+00	773.00
IUUC-Ttr-128481	Tursiops truncatus	76.22	0.00e+00	783.00
IUUC-Xtr-131907	Xenopus tropicalis	76.45	0.00e+00	797.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence