iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Post-translational Modifications (PTMs)
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.00e-08	35.2	547	585

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 547  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 585
           ********999******************......********** PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MAAVGPPQQQ VRMAQQQVWA ALEVALRVPC LYIIDAIFNS YYDSSQSRFC IGLQIFLRLL 60
GIVVSSIVLI LSQRSLFKFY MYSSAFLLAA TSVLVNYYAA LHIDFYGAYN TSAFGIELLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGCCCGCC CCGGCCGCGG CCCCGGGCCT CCCCCGCGCC GCCCTGCCTG GCCCGGCCCG 60
CCCAGCCCCG GTGTGGCAGC GGCTCATGGC GGCGGTGGGG CCCCCGCAGC AGCAGGTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

KEGG

mmu:75841

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	94.29	0.00e+00	1176.00
IUUC-Apl-004214	Anas platyrhynchos	84.40	0.00e+00	952.00
IUUC-Aca-005326	Anolis carolinensis	76.71	0.00e+00	954.00
IUUC-Ame-011687	Astyanax mexicanus	74.24	0.00e+00	859.00
IUUC-Bta-013394	Bos taurus	94.01	0.00e+00	1214.00
IUUC-Bci-013813	Botrytis cinerea	42.11	9.00e-08	51.60
IUUC-Cja-019499	Callithrix jacchus	92.81	0.00e+00	1219.00
IUUC-Cfa-020357	Canis familiaris	94.16	0.00e+00	1183.00
IUUC-Cpo-021924	Cavia porcellus	93.65	0.00e+00	1161.00
IUUC-Csa-023513	Chlorocebus sabaeus	94.16	0.00e+00	1206.00
IUUC-Cho-024285	Choloepus hoffmanni	87.59	0.00e+00	1054.00
IUUC-Cin-025223	Ciona intestinalis	53.18	8.00e-73	266.00
IUUC-Csv-026018	Ciona savignyi	46.69	8.00e-63	233.00
IUUC-Dre-028660	Danio rerio	72.22	0.00e+00	782.00
IUUC-Dno-029463	Dasypus novemcinctus	93.43	5.00e-157	547.00
IUUC-Dor-030728	Dipodomys ordii	93.30	0.00e+00	1121.00
IUUC-Dse-031284	Dothistroma septosporum	43.40	5.00e-09	55.10
IUUC-Dme-032186	Drosophila melanogaster	48.05	2.00e-97	350.00
IUUC-Ete-032368	Echinops telfairi	87.13	0.00e+00	1122.00
IUUC-Eca-034325	Equus caballus	93.42	0.00e+00	1147.00
IUUC-Fca-035537	Felis catus	93.40	0.00e+00	1159.00
IUUC-Fal-037459	Ficedula albicollis	84.73	0.00e+00	932.00
IUUC-Gmo-039442	Gadus morhua	78.28	2.00e-97	350.00
IUUC-Ggr-039921	Gaeumannomyces graminis	31.91	3.00e-08	53.90
IUUC-Gga-041071	Gallus gallus	80.71	0.00e+00	976.00
IUUC-Gac-042483	Gasterosteus aculeatus	67.08	0.00e+00	892.00
IUUC-Ggo-044672	Gorilla gorilla	93.86	0.00e+00	1202.00
IUUC-Hsa-045836	Homo sapiens	93.11	0.00e+00	1175.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	95.09	0.00e+00	1221.00
IUUC-Lch-050073	Latimeria chalumnae	74.08	0.00e+00	963.00
IUUC-Loc-052908	Lepisosteus oculatus	75.54	0.00e+00	936.00
IUUC-Laf-053519	Loxodonta africana	91.47	0.00e+00	1211.00
IUUC-Mcc-054674	Macaca mulatta	90.95	1.00e-92	332.00
IUUC-Mor-057262	Magnaporthe oryzae	31.18	3.00e-08	53.90
IUUC-Mga-059922	Meleagris gallopavo	83.75	0.00e+00	942.00
IUUC-Mmr-061452	Microcebus murinus	93.26	0.00e+00	1162.00
IUUC-Mdo-062412	Monodelphis domestica	87.56	0.00e+00	1143.00
IUUC-Mpu-065929	Mustela putorius furo	94.31	0.00e+00	1183.00
IUUC-Mlu-067899	Myotis lucifugus	90.57	0.00e+00	1152.00
IUUC-Nle-070083	Nomascus leucogenys	93.86	0.00e+00	1201.00
IUUC-Opr-070461	Ochotona princeps	89.84	0.00e+00	1191.00
IUUC-Ont-072256	Oreochromis niloticus	70.74	0.00e+00	907.00
IUUC-Oan-073150	Ornithorhynchus anatinus	82.86	0.00e+00	929.00
IUUC-Ocu-073748	Oryctolagus cuniculus	91.93	0.00e+00	1151.00
IUUC-Oga-088565	Otolemur garnettii	94.17	0.00e+00	1193.00
IUUC-Oar-089432	Ovis aries	93.74	0.00e+00	1144.00
IUUC-Ptr-091422	Pan troglodytes	93.71	0.00e+00	1201.00
IUUC-Pan-092331	Papio anubis	94.01	0.00e+00	1203.00
IUUC-Psi-092933	Pelodiscus sinensis	82.51	0.00e+00	927.00
IUUC-Pfo-097466	Poecilia formosa	69.47	0.00e+00	907.00
IUUC-Pab-098702	Pongo abelii	93.71	0.00e+00	1201.00
IUUC-Pca-100125	Procavia capensis	89.59	0.00e+00	1168.00
IUUC-Pva-102628	Pteropus vampyrus	94.15	0.00e+00	1176.00
IUUC-Rno-104886	Rattus norvegicus	98.00	0.00e+00	1282.00
IUUC-Sha-106702	Sarcophilus harrisii	85.29	0.00e+00	1128.00
IUUC-Ssc-116164	Sus scrofa	92.96	0.00e+00	1208.00
IUUC-Tgu-116829	Taeniopygia guttata	83.03	0.00e+00	967.00
IUUC-Tru-118557	Takifugu rubripes	65.69	0.00e+00	868.00
IUUC-Tsy-119399	Tarsius syrichta	88.32	0.00e+00	662.00
IUUC-Tni-120006	Tetraodon nigroviridis	63.68	0.00e+00	743.00
IUUC-Tbe-127664	Tupaia belangeri	92.20	0.00e+00	1173.00
IUUC-Ttr-129144	Tursiops truncatus	93.11	0.00e+00	1230.00
IUUC-Vpa-130226	Vicugna pacos	94.01	0.00e+00	1211.00
IUUC-Xtr-132461	Xenopus tropicalis	73.19	0.00e+00	903.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence