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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064413
UUCD1 version UUC-MuM-00827
Ensembl Protein ID ENSMUSP00000078641.3
UniProt Accession Q91VT1; Q8BQ88; Q9D1D3; NSE2_MOUSE
Genbank Protein ID BAB22938.1; BAC34589.1; AAH09125.1
Protein Name E3 SUMO-protein ligase NSE2; MMS21 homolog; Non-structural maintenance of chromosomes element 2 homolog
Genbank Nucleotide ID AK003685; AK051277; BC009125
Gene Name Nsmce2; Mms21
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000059586.9 ENSMUST00000079703.9 ENSMUSP00000078641.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 1.30e-10 42.3 165 242
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 4    eeflCpIslelMrdPvvlp.sGitydrssIekwlasggk.....tcPvtrqpl...teedlvPnltlrrliqawceen 72
             f+CpI+   M+ Pv  + +G+ty+ ++I + ++s++k      cP+ + +    + +dl+P  +lrr i+++ +++
   Q: 165  TNFICPITQLEMKKPVKNKmCGHTYEEEAIVRMIESKHKrkkkaCCPKIGCSHtdmRMSDLIPDEALRRAIESHNKKK 242
           57********************************99999999998887654442227799************998776 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).
 E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Required for sister chromatid cohesion during prometaphase and mitotic progression (By similarity).
Protein Sequence
(Fasta)
MPGRSSTSSG STRYISFSGI ESALSSLKNF QSCISSGMDT VSSVALDLVE TQTEVSSEYS 60
MDKAMVEFAK MDRELSHYVK AVQSTINHVK EERPEKVPDL KLLVEKKFLA LQDKNSDADF 120
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Protein Fasta Sequence


>IUUC-Mmu-064413|E3,U-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GGCCCGGGCC CGGGCATCAT GTGATCGCTC GCGGGCGCCA AGTGATGACG CAGAGCGCGC 60
GCGGGTCGTT TCAGCCACAG AAGTGGGCTG AGGAAAGGAG TCGGGGTCTG GGCGTGCGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064413|E3,U-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0436--Ligase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0779--Telomere
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR026846--Nse2(Mms21)
IPR003613--Ubox_domain
IPR004181--Znf_MIZ
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51044--ZF_SP_RING
Pfam

PF11789--zf-Nse
SMART

SM00504--Ubox
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0030915--C:Smc5-Smc6 complex
GO:0016874--F:ligase activity
GO:0019789--F:SUMO transferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0090398--P:cellular senescence
GO:0000724--P:double-strand break repair via homologous recombination
GO:0007067--P:mitotic nuclear division
GO:0034184--P:positive regulation of maintenance of mitotic sister chromatid cohesion
GO:0045842--P:positive regulation of mitotic metaphase/anaphase transition
GO:0000722--P:telomere maintenance via recombination
KEGG mmu:68501
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001627 Ailuropoda melanoleuca 88.89 9.00e-108 382.00
IUUC-Atr-002438 Amborella trichopoda 34.85 6.00e-06 44.70
IUUC-Apl-004091 Anas platyrhynchos 61.86 2.00e-30 123.00
IUUC-Aca-004433 Anolis carolinensis 52.40 2.00e-70 258.00
IUUC-Ath-007424 Arabidopsis thaliana 25.77 2.00e-08 52.80
IUUC-Ago-007852 Ashbya gossypii 29.73 9.00e-08 50.10
IUUC-Acl-008011 Aspergillus clavatus 32.56 5.00e-03 36.20
IUUC-Afl-008461 Aspergillus flavus 46.67 8.00e-03 35.00
IUUC-Afu-008893 Aspergillus fumigatus 32.56 1.00e-03 38.10
IUUC-Ani-009414 Aspergillus nidulans 31.82 5.00e-04 39.30
IUUC-Ang-009587 Aspergillus niger 40.00 3.00e-03 37.00
IUUC-Ate-010326 Aspergillus terreus 34.88 6.00e-03 37.00
IUUC-Ame-010902 Astyanax mexicanus 41.48 2.00e-45 175.00
IUUC-Bgr-012088 Blumeria graminis 21.89 2.00e-06 46.60
IUUC-Bta-013397 Bos taurus 88.64 2.00e-71 261.00
IUUC-Bci-013738 Botrytis cinerea 25.00 2.00e-05 43.50
IUUC-Cel-018588 Caenorhabditis elegans 30.00 1.00e-02 33.10
IUUC-Cja-019246 Callithrix jacchus 89.47 6.00e-110 389.00
IUUC-Cpo-021670 Cavia porcellus 88.21 1.00e-98 352.00
IUUC-Csa-023982 Chlorocebus sabaeus 84.21 3.00e-101 360.00
IUUC-Cin-025127 Ciona intestinalis 24.32 1.00e-15 77.00
IUUC-Cgl-026430 Colletotrichum gloeosporioides 32.20 6.00e-07 48.50
IUUC-Cne-026806 Cryptococcus neoformans 28.83 3.00e-09 55.80
IUUC-Cme-027175 Cyanidioschyzon merolae 29.58 9.00e-06 44.30
IUUC-Dre-028325 Danio rerio 36.45 2.00e-33 135.00
IUUC-Dno-029735 Dasypus novemcinctus 89.91 2.00e-121 427.00
IUUC-Dor-030454 Dipodomys ordii 73.09 2.00e-76 278.00
IUUC-Dme-031971 Drosophila melanogaster 28.42 6.00e-08 50.80
IUUC-Ete-032838 Echinops telfairi 65.16 3.00e-52 197.00
IUUC-Eca-034371 Equus caballus 88.60 5.00e-118 416.00
IUUC-Eeu-035258 Erinaceus europaeus 86.56 2.00e-82 297.00
IUUC-Fca-035576 Felis catus 89.78 2.00e-106 378.00
IUUC-Fal-037038 Ficedula albicollis 56.39 1.00e-74 272.00
IUUC-Fox-037843 Fusarium oxysporum 31.43 2.00e-05 43.10
IUUC-Fso-038272 Fusarium solani 31.25 5.00e-06 45.40
IUUC-Ggr-040059 Gaeumannomyces graminis 28.57 2.00e-06 47.00
IUUC-Gga-040737 Gallus gallus 44.40 2.00e-57 216.00
IUUC-Gac-042591 Gasterosteus aculeatus 42.80 6.00e-44 170.00
IUUC-Ggo-045206 Gorilla gorilla 84.21 3.00e-102 364.00
IUUC-Hsa-046704 Homo sapiens 84.65 5.00e-103 367.00
IUUC-Itr-048972 Ictidomys tridecemlineatus 89.15 6.00e-46 176.00
IUUC-Kpa-049181 Komagataella pastoris 26.96 2.00e-10 60.10
IUUC-Loc-052687 Lepisosteus oculatus 40.97 6.00e-42 164.00
IUUC-Lma-053255 Leptosphaeria maculans 31.34 9.00e-06 45.10
IUUC-Laf-054270 Loxodonta africana 83.76 1.00e-106 379.00
IUUC-Mcc-054757 Macaca mulatta 83.96 1.00e-79 288.00
IUUC-Mor-057028 Magnaporthe oryzae 23.45 4.00e-07 49.30
IUUC-Mpo-057462 Magnaporthe poae 28.57 3.00e-07 49.70
IUUC-Mtr-058011 Medicago truncatula 25.93 2.00e-10 58.90
IUUC-Mga-059215 Meleagris gallopavo 66.67 3.00e-33 133.00
IUUC-Mvi-060511 Microbotryum violaceum 32.47 6.00e-07 48.50
IUUC-Mmr-061584 Microcebus murinus 85.02 3.00e-100 357.00
IUUC-Mdo-061863 Monodelphis domestica 54.82 2.00e-73 268.00
IUUC-Mac-065639 Musa acuminata 29.70 4.00e-05 42.00
IUUC-Mpu-066092 Mustela putorius furo 75.10 1.00e-103 369.00
IUUC-Mlu-068198 Myotis lucifugus 88.00 8.00e-118 416.00
IUUC-Nfi-068508 Neosartorya fischeri 27.94 1.00e-03 38.50
IUUC-Nle-070109 Nomascus leucogenys 85.09 1.00e-104 372.00
IUUC-Opr-070540 Ochotona princeps 60.36 2.00e-62 231.00
IUUC-Ont-071575 Oreochromis niloticus 42.17 3.00e-44 171.00
IUUC-Oan-072777 Ornithorhynchus anatinus 76.19 4.00e-24 102.00
IUUC-Ocu-074730 Oryctolagus cuniculus 90.67 9.00e-110 389.00
IUUC-Oga-087925 Otolemur garnettii 88.16 3.00e-100 357.00
IUUC-Oar-090138 Ovis aries 76.47 1.00e-97 349.00
IUUC-Ptr-091582 Pan troglodytes 84.65 5.00e-103 367.00
IUUC-Pan-092890 Papio anubis 84.21 4.00e-101 360.00
IUUC-Psi-093714 Pelodiscus sinensis 56.09 3.00e-75 275.00
IUUC-Pma-094198 Petromyzon marinus 30.94 1.00e-19 88.60
IUUC-Pno-094931 Phaeosphaeria nodorum 32.47 5.00e-05 42.70
IUUC-Pab-098005 Pongo abelii 84.21 7.00e-103 366.00
IUUC-Pca-100368 Procavia capensis 67.54 8.00e-64 236.00
IUUC-Ppe-101873 Prunus persica 24.73 9.00e-09 53.90
IUUC-Pva-102951 Pteropus vampyrus 89.59 7.00e-111 392.00
IUUC-Pte-104390 Pyrenophora teres 38.46 1.00e-05 44.30
IUUC-Pyt-104633 Pyrenophora triticirepentis 38.46 1.00e-05 43.90
IUUC-Rno-105346 Rattus norvegicus 97.17 2.00e-126 444.00
IUUC-Sha-107586 Sarcophilus harrisii 69.29 3.00e-41 160.00
IUUC-Sja-107983 Schizosaccharomyces japonicus 34.78 3.00e-10 58.90
IUUC-Spo-108327 Schizosaccharomyces pombe 29.35 8.00e-05 40.80
IUUC-Ssl-108555 Sclerotinia sclerotiorum 30.00 3.00e-06 46.20
IUUC-Sar-113609 Sorex araneus 86.75 3.00e-101 360.00
IUUC-Sre-115187 Sporisorium reilianum 27.88 2.00e-06 46.60
IUUC-Tgu-116472 Taeniopygia guttata 54.63 1.00e-69 255.00
IUUC-Tru-117771 Takifugu rubripes 40.17 6.00e-41 160.00
IUUC-Tni-119821 Tetraodon nigroviridis 37.77 4.00e-43 167.00
IUUC-Tca-121272 Theobroma cacao 28.08 2.00e-05 43.10
IUUC-Tre-122049 Trichoderma reesei 32.93 1.00e-08 54.30
IUUC-Tvi-122642 Trichoderma virens 30.49 4.00e-07 49.30
IUUC-Tme-126988 Tuber melanosporum 32.26 5.00e-06 45.10
IUUC-Tbe-127676 Tupaia belangeri 88.72 3.00e-90 324.00
IUUC-Ttr-128602 Tursiops truncatus 87.28 4.00e-106 377.00
IUUC-Vpa-130510 Vicugna pacos 90.22 2.00e-108 385.00
IUUC-Vvi-131486 Vitis vinifera 29.57 4.00e-10 58.20
Created Date 25-Jun-2017

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