iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-089173

Ensembl Protein ID

ENSOGAP00000009435.2

UniProt Accession

H0X2X6; H0X2X6_OTOGA

Genbank Protein ID

ENSOGAP00000009435

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03161684

Gene Name

DDX58

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000010536.2	ENSOGAT00000010542.2	ENSOGAP00000009435.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	4.00e-51	171.5	1	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 1    tdeeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL..vqkegWfrefl 73
           +++e+rl l ++ d+vrk+Ld+t +l+ y++++++e e+++i+a++++kg+m+aa+l+Lk L  +q+egWfr+fl
   Q: 1    MTTEQRLNLHAFGDYVRKTLDPTHILS-YMAPWFREDEVQYIQAEKNNKGPMEAATLFLKLLleLQEEGWFRAFL 74
           689************************.*********************************************96 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MTTEQRLNLH AFGDYVRKTL DPTHILSYMA PWFREDEVQY IQAEKNNKGP MEAATLFLKL 60
LLELQEEGWF RAFLDALNQA GYSGLYEAIE SWDFQKIEKL EDYRSLLKRL QPEFKARIIP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCACCG AGCAGCGGCT GAATCTGCAC GCTTTTGGGG ACTATGTCCG GAAGACGCTG 60
GACCCTACCC ACATCCTGAG CTACATGGCC CCCTGGTTCA GGGAGGGTGA GTGTTTTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR031964--CARD_dom
IPR011029--DEATH-like_dom
IPR006935--Helicase/UvrB_N
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR021673--RLR_CTR

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51789--RLR_CTR

Pfam

PF16739--CARD_2
PF00271--Helicase_C
PF04851--ResIII
PF11648--RIG-I_C-RD

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005923--C:bicellular tight junction
GO:0005829--C:cytosol
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0003690--F:double-stranded DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0016817--F:hydrolase activity, acting on acid anhydrides
GO:0003727--F:single-stranded RNA binding
GO:0008270--F:zinc ion binding
GO:0009597--P:detection of virus
GO:0045087--P:innate immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0032725--P:positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032727--P:positive regulation of interferon-alpha production
GO:0032728--P:positive regulation of interferon-beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030334--P:regulation of cell migration
GO:0043330--P:response to exogenous dsRNA
GO:0039529--P:RIG-I signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001898	Ailuropoda melanoleuca	78.41	0.00e+00	1425.00
IUUC-Apl-003966	Anas platyrhynchos	53.26	0.00e+00	878.00
IUUC-Aca-004499	Anolis carolinensis	45.69	0.00e+00	747.00
IUUC-Ame-011950	Astyanax mexicanus	42.71	0.00e+00	645.00
IUUC-Bta-012489	Bos taurus	77.93	0.00e+00	1406.00
IUUC-Cel-018230	Caenorhabditis elegans	30.49	2.00e-64	240.00
IUUC-Cja-018716	Callithrix jacchus	83.80	0.00e+00	1511.00
IUUC-Cfa-020269	Canis familiaris	80.73	0.00e+00	1452.00
IUUC-Cpo-022507	Cavia porcellus	75.86	0.00e+00	1371.00
IUUC-Csa-024209	Chlorocebus sabaeus	84.02	0.00e+00	1550.00
IUUC-Cho-025104	Choloepus hoffmanni	73.76	0.00e+00	1180.00
IUUC-Cin-025792	Ciona intestinalis	31.68	9.00e-76	278.00
IUUC-Cgl-026385	Colletotrichum gloeosporioides	24.54	3.00e-19	91.30
IUUC-Dno-028954	Dasypus novemcinctus	77.47	0.00e+00	1388.00
IUUC-Eca-034039	Equus caballus	81.06	0.00e+00	1490.00
IUUC-Eeu-035009	Erinaceus europaeus	68.75	0.00e+00	905.00
IUUC-Fca-036169	Felis catus	80.88	0.00e+00	1489.00
IUUC-Fal-037579	Ficedula albicollis	53.02	0.00e+00	882.00
IUUC-Ggo-045318	Gorilla gorilla	82.27	0.00e+00	1431.00
IUUC-Hsa-046671	Homo sapiens	84.45	0.00e+00	1553.00
IUUC-Itr-047996	Ictidomys tridecemlineatus	76.92	0.00e+00	1422.00
IUUC-Lch-050461	Latimeria chalumnae	50.38	0.00e+00	838.00
IUUC-Loc-052582	Lepisosteus oculatus	47.52	0.00e+00	795.00
IUUC-Laf-054324	Loxodonta africana	78.05	0.00e+00	1404.00
IUUC-Mcc-055390	Macaca mulatta	83.48	0.00e+00	1533.00
IUUC-Meu-056365	Macropus eugenii	54.39	3.00e-175	608.00
IUUC-Mmr-061407	Microcebus murinus	85.42	0.00e+00	1594.00
IUUC-Mmu-063939	Mus musculus	73.59	0.00e+00	1313.00
IUUC-Mpu-066226	Mustela putorius furo	78.47	0.00e+00	1325.00
IUUC-Mlu-068092	Myotis lucifugus	80.86	0.00e+00	1442.00
IUUC-Nfi-068405	Neosartorya fischeri	23.91	2.00e-23	105.00
IUUC-Opr-070246	Ochotona princeps	66.53	0.00e+00	672.00
IUUC-Oan-072742	Ornithorhynchus anatinus	60.49	0.00e+00	938.00
IUUC-Ocu-073959	Oryctolagus cuniculus	74.57	0.00e+00	1380.00
IUUC-Oar-089369	Ovis aries	77.18	0.00e+00	1381.00
IUUC-Ptr-091032	Pan troglodytes	84.45	0.00e+00	1553.00
IUUC-Pan-092383	Papio anubis	83.60	0.00e+00	1531.00
IUUC-Psi-093432	Pelodiscus sinensis	55.54	0.00e+00	997.00
IUUC-Pma-094367	Petromyzon marinus	41.11	8.00e-110	390.00
IUUC-Pab-098416	Pongo abelii	84.13	0.00e+00	1451.00
IUUC-Pca-101006	Procavia capensis	75.95	3.00e-179	622.00
IUUC-Pva-102966	Pteropus vampyrus	80.54	0.00e+00	1468.00
IUUC-Rno-105059	Rattus norvegicus	74.49	0.00e+00	877.00
IUUC-Ssl-108450	Sclerotinia sclerotiorum	27.55	2.00e-03	39.70
IUUC-Sar-113202	Sorex araneus	66.58	0.00e+00	999.00
IUUC-Ssc-116120	Sus scrofa	78.26	0.00e+00	1414.00
IUUC-Tgu-117314	Taeniopygia guttata	52.18	0.00e+00	885.00
IUUC-Tsy-119453	Tarsius syrichta	81.38	0.00e+00	826.00
IUUC-Tre-122194	Trichoderma reesei	25.19	4.00e-18	87.40
IUUC-Ttr-128421	Tursiops truncatus	75.99	0.00e+00	1159.00
IUUC-Vpa-130602	Vicugna pacos	77.53	0.00e+00	1364.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence