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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046399
Ensembl Protein ID ENSP00000444293.1
UniProt Accession Q9BY66; A2RU19; A6H8V7; B7ZLX1; Q92509; Q92809; Q9HCU1; KDM5D_HUMAN
Genbank Protein ID AAC50806.1; BAA13241.2; AAG00951.1; EAW54663.1; AAI32722.1; AAI44103.1; AAI46768.1; AAC51135.1; AAK27839.1
Protein Name Lysine-specific demethylase 5D; Histocompatibility Y antigen; Histone demethylase JARID1D; Jumonji/ARID domain-containing protein 1D; Protein SmcY
Genbank Nucleotide ID U52191; D87072; AF273841; AC010889; BC132721; BC144102; BC146767; U52365; AF134849
Gene Name KDM5D; HY; HYA; JARID1D; KIAA0234; SMCY
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000012817.15 ENST00000317961.8 ENSP00000322408.4
ENSG00000012817.15 ENST00000382806.6 ENSP00000372256.2
ENSG00000012817.15 ENST00000440077.5 ENSP00000398543.1
ENSG00000012817.15 ENST00000415360.1 ENSP00000389433.1
ENSG00000012817.15 ENST00000447300.1 ENSP00000416377.1
ENSG00000012817.15 ENST00000541639.5 ENSP00000444293.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
circBasecircRNADbCircNetmiRTarBase
microRNATRANSFACmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
OMIM
Drug and target
DrugBankGRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMBioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 3.20e-14 54.5 316 362
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +g+ed+ +l+ C+ C++++H  Cl ++  +e p+   w CpkC 
   Q: 316  ICQVCSRGDEDD-KLLFCDGCDDNYHIFCLLPP-LPEIPRGI-WRCPKCI 362
           7*********88.6*******************.******97.******5 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
 Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
Protein Sequence
(Fasta)
MEPGCDEFLP PPECPVFEPS WAEFQDPLGY IAKIRPIAEK SGICKIRPPA DWQPPFAVEV 60
DNFRFTPRVQ RLNELEAQTR VKLNYLDQIA KFWEIQGSSL KIPNVERKIL DLYSLSKIVI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046399|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
CATTTTAAAA AAGATCCGGC CATACTATTT TTATCTTGCT TTTTCGTTCT GTCGCAGTAC 60
TGTTTAATAT GAGTCCAGCG ACGGCTCTGT GACTGTTTTC CTCTGGTAAA ATCGCTCTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046399|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2
SMART

SM00501--BRIGHT
SM00558--JmjC
SM00545--JmjN
SM00249--PHD
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0050681--F:androgen receptor binding
GO:0003677--F:DNA binding
GO:0032452--F:histone demethylase activity
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0034720--P:histone H3-K4 demethylation
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0002457--P:T cell antigen processing and presentation
GO:0006351--P:transcription, DNA-templated
KEGG hsa:8284
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Csa-023682 Chlorocebus sabaeus 93.06 0.00e+00 2684.00
IUUC-Gmo-039140 Gadus morhua 60.15 0.00e+00 1689.00
IUUC-Mcc-055474 Macaca mulatta 95.41 0.00e+00 2801.00
IUUC-Ptr-091415 Pan troglodytes 97.01 0.00e+00 2778.00
Created Date 25-Jun-2017

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