iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046302

UUCD1 version

UUC-HoS-00399

Ensembl Protein ID

ENSP00000351813.2

UniProt Accession

Q9NX47; MARH5_HUMAN

Genbank Protein ID

BAF02285.1; BAA91173.1; CAI13639.1; CAI13639.1; CAI15361.1; CAI15361.1; AAH15480.1

Protein Name

E3 ubiquitin-protein ligase MARCH5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; Mitochondrial ubiquitin ligase; RING finger protein 153; RING-type E3 ubiquitin transferase MARCH5

Genbank Nucleotide ID

AB191202; AK000452; AL158040; AL161652; AL161652; AL158040; BC015480

Gene Name

MARCH5; RNF153

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000198060.9	ENST00000358935.2	ENSP00000351813.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	HPRD
BioGRID
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16874301; 19741096; 20851218; 20103533

Classification

Family	E-value	Score	Start	End
E3 activity/RING/PHD	1.20e-11	46.2	12	70
E3 activity/RING/RING	0.39	12.9	14	69

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedek...slveCek..CrewfHpaClklsveeelpnsek..wiCpkCrs 53
           ++C+vC++++ed++   ++  C++  +++w+H+aCl+++v+e+++++++  ++Cp+C++
   Q: 12   RSCWVCFATDEDDRtaeWVRPCRCrgSTKWVHQACLQRWVDEKQRGNSTarVACPQCNA 70
           68***********7778******999*********************9999******97 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdg....plvlpCgHv.....fhadClqkw..pglknssskefrCPlCr 46
           C +C+   +d     ++  pC         h+ Clq+w    +  +s  +  CP C+
   Q: 14   CWVCFATDEDDrtaeWV-RPCRCRgstkwVHQACLQRWvdEKQRGNSTARVACPQCN 69
           77776655332222222.456543456657********65333334555557****7 PP

Organism

Homo sapiens

Functional Description
(View)

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.

Protein Sequence
(Fasta)

MPDQALQQML DRSCWVCFAT DEDDRTAEWV RPCRCRGSTK WVHQACLQRW VDEKQRGNST 60
ARVACPQCNA EYLIVFPKLG PVVYVLDLAD RLISKACPFA AAGIMVGSIY WTAVTYGAVT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTACCTCA CAAAGGTAGC TCCTCCGCCG GCAGCAACTC GGCGCCCGCG GTCCATGGAC 60
CGGAACCTCG GGCCGACGGA CGGGAACCCG GGCCGCGATC GCCGCCTCCC CGCCTCAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0051020--F:GTPase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0090344--P:negative regulation of cell aging
GO:0090141--P:positive regulation of mitochondrial fission
GO:0051865--P:protein autoubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0000209--P:protein polyubiquitination
GO:0090140--P:regulation of mitochondrial fission

KEGG

hsa:54708

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002055	Ailuropoda melanoleuca	98.89	1.00e-159	555.00
IUUC-Apl-004106	Anas platyrhynchos	99.25	2.00e-157	548.00
IUUC-Aca-004615	Anolis carolinensis	97.46	3.00e-160	556.00
IUUC-Acl-008017	Aspergillus clavatus	26.47	2.00e-10	60.50
IUUC-Afl-008538	Aspergillus flavus	22.22	2.00e-05	44.30
IUUC-Afu-008855	Aspergillus fumigatus	24.81	1.00e-10	61.20
IUUC-Ani-009440	Aspergillus nidulans	28.77	7.00e-07	47.80
IUUC-Ang-009850	Aspergillus niger	24.24	3.00e-09	56.60
IUUC-Ate-010339	Aspergillus terreus	26.25	1.00e-11	64.70
IUUC-Ame-011363	Astyanax mexicanus	96.80	4.00e-162	563.00
IUUC-Bgr-012038	Blumeria graminis	31.50	7.00e-08	52.40
IUUC-Bta-013194	Bos taurus	100.00	1.00e-159	555.00
IUUC-Bci-013963	Botrytis cinerea	25.83	5.00e-08	52.80
IUUC-Bdi-014566	Brachypodium distachyon	43.06	9.00e-09	53.90
IUUC-Cel-018634	Caenorhabditis elegans	40.91	4.00e-10	57.80
IUUC-Cja-019097	Callithrix jacchus	97.04	3.00e-157	547.00
IUUC-Cfa-020404	Canis familiaris	99.28	7.00e-165	572.00
IUUC-Cpo-022094	Cavia porcellus	100.00	2.00e-166	577.00
IUUC-Csa-023955	Chlorocebus sabaeus	100.00	2.00e-166	577.00
IUUC-Cho-024819	Choloepus hoffmanni	94.98	1.00e-118	418.00
IUUC-Cin-025730	Ciona intestinalis	60.00	3.00e-99	354.00
IUUC-Csv-025975	Ciona savignyi	58.89	1.00e-97	349.00
IUUC-Cgl-026746	Colletotrichum gloeosporioides	30.83	3.00e-06	45.10
IUUC-Dre-027676	Danio rerio	97.44	4.00e-160	556.00
IUUC-Dno-029876	Dasypus novemcinctus	99.64	6.00e-166	576.00
IUUC-Dor-030204	Dipodomys ordii	95.96	6.00e-106	376.00
IUUC-Dse-031226	Dothistroma septosporum	26.52	2.00e-10	60.50
IUUC-Dme-031751	Drosophila melanogaster	53.48	3.00e-83	301.00
IUUC-Ete-032941	Echinops telfairi	100.00	2.00e-166	577.00
IUUC-Eca-033559	Equus caballus	100.00	2.00e-166	577.00
IUUC-Eeu-034761	Erinaceus europaeus	97.37	2.00e-153	534.00
IUUC-Fca-035951	Felis catus	100.00	2.00e-166	577.00
IUUC-Fal-036756	Ficedula albicollis	98.17	3.00e-160	557.00
IUUC-Fox-037934	Fusarium oxysporum	28.46	2.00e-07	50.80
IUUC-Fso-038122	Fusarium solani	26.35	8.00e-09	55.50
IUUC-Gmo-038695	Gadus morhua	92.54	2.00e-147	514.00
IUUC-Gga-040911	Gallus gallus	98.18	1.00e-160	558.00
IUUC-Gac-042449	Gasterosteus aculeatus	96.25	7.00e-154	536.00
IUUC-Ggo-045555	Gorilla gorilla	100.00	2.00e-166	577.00
IUUC-Itr-048942	Ictidomys tridecemlineatus	100.00	2.00e-166	577.00
IUUC-Kpa-049406	Komagataella pastoris	22.22	6.00e-03	35.80
IUUC-Lch-050077	Latimeria chalumnae	97.43	2.00e-159	554.00
IUUC-Loc-052045	Lepisosteus oculatus	96.80	1.00e-161	561.00
IUUC-Lma-053141	Leptosphaeria maculans	25.71	2.00e-08	54.70
IUUC-Laf-053982	Loxodonta africana	99.64	3.00e-164	570.00
IUUC-Mcc-055278	Macaca mulatta	100.00	2.00e-166	577.00
IUUC-Meu-056185	Macropus eugenii	99.25	3.00e-157	546.00
IUUC-Mor-057070	Magnaporthe oryzae	26.04	2.00e-07	50.80
IUUC-Mpo-057293	Magnaporthe poae	23.97	2.00e-05	44.30
IUUC-Mla-059023	Melampsora laricipopulina	25.19	1.00e-06	48.50
IUUC-Mga-060064	Meleagris gallopavo	97.06	2.00e-156	544.00
IUUC-Mvi-060427	Microbotryum violaceum	27.20	3.00e-07	50.80
IUUC-Mmr-060872	Microcebus murinus	100.00	2.00e-166	577.00
IUUC-Mdo-062907	Monodelphis domestica	100.00	2.00e-166	577.00
IUUC-Mmu-063792	Mus musculus	100.00	2.00e-166	577.00
IUUC-Mpu-065948	Mustela putorius furo	100.00	3.00e-166	577.00
IUUC-Mlu-067399	Myotis lucifugus	100.00	3.00e-159	554.00
IUUC-Nfi-068312	Neosartorya fischeri	25.00	1.00e-10	61.20
IUUC-Ncr-068837	Neurospora crassa	30.83	4.00e-12	67.00
IUUC-Nle-069197	Nomascus leucogenys	100.00	2.00e-166	577.00
IUUC-Opr-070474	Ochotona princeps	93.17	1.00e-151	528.00
IUUC-Ont-071896	Oreochromis niloticus	47.41	6.00e-73	267.00
IUUC-Oan-073425	Ornithorhynchus anatinus	98.56	2.00e-164	571.00
IUUC-Ocu-074127	Oryctolagus cuniculus	100.00	2.00e-166	577.00
IUUC-Ola-086561	Oryzias latipes	98.50	2.00e-156	544.00
IUUC-Oga-089004	Otolemur garnettii	100.00	6.00e-160	556.00
IUUC-Oar-089485	Ovis aries	98.15	4.00e-159	553.00
IUUC-Ptr-091645	Pan troglodytes	100.00	2.00e-166	577.00
IUUC-Pan-092408	Papio anubis	100.00	2.00e-166	577.00
IUUC-Psi-093325	Pelodiscus sinensis	93.04	3.00e-149	520.00
IUUC-Pma-094495	Petromyzon marinus	85.00	6.00e-87	313.00
IUUC-Pno-094820	Phaeosphaeria nodorum	26.40	2.00e-08	54.30
IUUC-Pfo-097381	Poecilia formosa	97.43	4.00e-158	550.00
IUUC-Pab-097888	Pongo abelii	100.00	2.00e-166	577.00
IUUC-Pva-102265	Pteropus vampyrus	100.00	2.00e-166	577.00
IUUC-Pgr-103326	Puccinia graminis	23.97	1.10e-02	35.40
IUUC-Pte-104347	Pyrenophora teres	26.97	6.00e-10	59.30
IUUC-Pyt-104598	Pyrenophora triticirepentis	38.00	6.00e-07	48.10
IUUC-Rno-105983	Rattus norvegicus	100.00	2.00e-166	577.00
IUUC-Sha-106483	Sarcophilus harrisii	99.26	2.00e-159	555.00
IUUC-Sja-107897	Schizosaccharomyces japonicus	28.05	4.00e-05	42.40
IUUC-Spo-108227	Schizosaccharomyces pombe	27.81	4.00e-06	45.80
IUUC-Sar-113087	Sorex araneus	96.24	5.00e-152	529.00
IUUC-Sre-114892	Sporisorium reilianum	25.73	5.00e-14	72.80
IUUC-Ssc-115964	Sus scrofa	97.12	2.00e-161	561.00
IUUC-Tgu-117325	Taeniopygia guttata	99.25	4.00e-158	550.00
IUUC-Tru-118291	Takifugu rubripes	95.83	2.00e-107	381.00
IUUC-Tsy-119454	Tarsius syrichta	83.08	4.00e-127	447.00
IUUC-Tni-119754	Tetraodon nigroviridis	95.85	3.00e-148	517.00
IUUC-Tre-122138	Trichoderma reesei	32.52	2.00e-08	53.90
IUUC-Tvi-122629	Trichoderma virens	31.97	5.00e-09	55.80
IUUC-Tbe-127988	Tupaia belangeri	100.00	1.00e-142	498.00
IUUC-Ttr-128413	Tursiops truncatus	100.00	1.00e-135	474.00
IUUC-Uma-129544	Ustilago maydis	25.99	6.00e-16	79.30
IUUC-Vda-129998	Verticillium dahliae	29.57	2.00e-07	50.40
IUUC-Vpa-130036	Vicugna pacos	96.76	3.00e-160	556.00
IUUC-Xtr-131932	Xenopus tropicalis	95.57	4.00e-154	536.00
IUUC-Xma-134072	Xiphophorus maculatus	97.43	4.00e-158	550.00
IUUC-Zma-135012	Zea mays	46.51	9.00e-09	51.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence