iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063925

Ensembl Protein ID

ENSMUSP00000109765.2

UniProt Accession

O88522; Q924H4; NEMO_MOUSE

Genbank Protein ID

AAC40153.1; AAK69186.1; AAP47160.1; BAE32372.1; CAM45971.1; EDL29810.1

Protein Name

NF-kappa-B essential modulator; IkB kinase-associated protein 1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; NF-kappa-B essential modifier

Genbank Nucleotide ID

AF069542; AF326207; AF513109; AK154095; AL669976; CH466650

Gene Name

Ikbkg; Nemo

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000004221.16	ENSMUST00000114129.8	ENSMUSP00000109764.2
ENSMUSG00000004221.16	ENSMUST00000138564.7	ENSMUSP00000118884.1
ENSMUSG00000004221.16	ENSMUST00000004330.9	ENSMUSP00000004330.3
ENSMUSG00000004221.16	ENSMUST00000114130.8	ENSMUSP00000109765.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	BioGRID	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBAN	UBAN	9927690; 17702576

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBAN	4.20e-25	88.6	296	355

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +++++etv+vLk+Q++iYk+DFqaER++RE+l e+ke Lqeq+e+lq++ +kl+ ++++s
   Q: 296  HKIVMETVPVLKAQADIYKADFQAERHAREKLVEKKEYLQEQLEQLQREFNKLKVGCHES 355
           899***************************************************999887 PP

Organism

Mus musculus

Functional Description
(View)

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

Protein Sequence
(Fasta)

MRCLENGTLS CWMNKHPWKN QLSEMVQPSG GPAEDQDMLG EESSLGKPAM LHLPSEQGTP 60
ETLQRCLEEN QELRDAIRQS NQMLRERCEE LLHFQVSQRE EKEFLMCKFQ EARKLVERLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGGCTGGG TGGGAGGTGC CGAGTGTGGC TGTGCACTCC TCTTGTGCTA AAGCTGAGCC 60
GCCTAGCTTC CTACAGTGTC ACTGCTTCAA GATGAAATCT CCTTCTAGAC TTTGAGGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0227--DNA damage
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0008385--C:IkappaB kinase complex
GO:0005622--C:intracellular
GO:0072686--C:mitotic spindle
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0000151--C:ubiquitin ligase complex
GO:0070530--F:K63-linked polyubiquitin binding
GO:1990450--F:linear polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0019904--F:protein domain specific binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0043276--P:anoikis
GO:0001782--P:B cell homeostasis
GO:0006974--P:cellular response to DNA damage stimulus
GO:0051650--P:establishment of vesicle localization
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010628--P:positive regulation of gene expression
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016239--P:positive regulation of macroautophagy
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:16151

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002336	Ailuropoda melanoleuca	86.76	1.00e-172	599.00
IUUC-Aca-004653	Anolis carolinensis	60.80	6.00e-99	354.00
IUUC-Bta-012778	Bos taurus	83.05	5.00e-169	587.00
IUUC-Cja-018954	Callithrix jacchus	87.17	2.00e-175	608.00
IUUC-Cfa-020778	Canis familiaris	85.45	0.00e+00	669.00
IUUC-Cpo-022327	Cavia porcellus	83.33	2.00e-144	505.00
IUUC-Csa-023340	Chlorocebus sabaeus	87.05	2.00e-147	515.00
IUUC-Dre-028819	Danio rerio	46.79	4.00e-55	209.00
IUUC-Dno-029566	Dasypus novemcinctus	83.85	3.00e-157	548.00
IUUC-Dor-031122	Dipodomys ordii	80.82	3.00e-32	132.00
IUUC-Eca-033895	Equus caballus	81.77	2.00e-146	511.00
IUUC-Eeu-034478	Erinaceus europaeus	73.82	3.00e-125	441.00
IUUC-Fca-035990	Felis catus	86.41	1.00e-120	427.00
IUUC-Gmo-038622	Gadus morhua	46.65	4.00e-62	232.00
IUUC-Gac-041917	Gasterosteus aculeatus	47.52	2.00e-60	227.00
IUUC-Ggo-045478	Gorilla gorilla	86.15	1.00e-165	575.00
IUUC-Hsa-046243	Homo sapiens	85.92	5.00e-165	573.00
IUUC-Itr-048520	Ictidomys tridecemlineatus	89.93	0.00e+00	634.00
IUUC-Lch-050187	Latimeria chalumnae	58.38	1.00e-100	359.00
IUUC-Loc-052627	Lepisosteus oculatus	55.48	2.00e-60	227.00
IUUC-Laf-054387	Loxodonta africana	86.16	7.00e-149	520.00
IUUC-Mcc-054611	Macaca mulatta	86.15	3.00e-165	575.00
IUUC-Meu-056530	Macropus eugenii	74.83	5.00e-47	181.00
IUUC-Mmr-061028	Microcebus murinus	83.41	2.00e-177	615.00
IUUC-Mdo-062520	Monodelphis domestica	62.36	2.00e-110	392.00
IUUC-Mpu-066392	Mustela putorius furo	83.98	5.00e-153	533.00
IUUC-Mlu-067374	Myotis lucifugus	81.31	2.00e-151	528.00
IUUC-Nle-069085	Nomascus leucogenys	87.86	1.00e-83	301.00
IUUC-Ont-071385	Oreochromis niloticus	47.20	1.00e-55	211.00
IUUC-Oan-073347	Ornithorhynchus anatinus	67.99	7.00e-143	500.00
IUUC-Ocu-074929	Oryctolagus cuniculus	83.57	2.00e-175	608.00
IUUC-Ola-086340	Oryzias latipes	47.58	6.00e-65	241.00
IUUC-Oga-088042	Otolemur garnettii	86.19	2.00e-174	605.00
IUUC-Oar-090051	Ovis aries	84.99	1.00e-157	549.00
IUUC-Ptr-090498	Pan troglodytes	85.21	7.00e-163	566.00
IUUC-Psi-093840	Pelodiscus sinensis	58.65	3.00e-79	289.00
IUUC-Pfo-097140	Poecilia formosa	45.43	4.00e-53	202.00
IUUC-Pab-097707	Pongo abelii	85.61	2.00e-165	575.00
IUUC-Pca-100427	Procavia capensis	71.93	3.00e-123	435.00
IUUC-Pva-102328	Pteropus vampyrus	79.58	1.00e-142	499.00
IUUC-Ptt-103739	Puccinia triticina	28.30	1.00e+00	28.50
IUUC-Rno-105231	Rattus norvegicus	97.09	0.00e+00	688.00
IUUC-Sha-106676	Sarcophilus harrisii	72.07	2.00e-145	508.00
IUUC-Sar-113027	Sorex araneus	73.66	3.00e-66	244.00
IUUC-Ssc-116284	Sus scrofa	84.49	3.00e-144	504.00
IUUC-Tru-117790	Takifugu rubripes	44.55	4.00e-49	189.00
IUUC-Tbe-127949	Tupaia belangeri	81.63	9.00e-55	207.00
IUUC-Ttr-128663	Tursiops truncatus	83.97	7.00e-164	570.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence