iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000074643.12	ENSMUST00000184265.7	ENSMUSP00000138888.1
ENSMUSG00000074643.12	ENSMUST00000109607.9	ENSMUSP00000105236.2
ENSMUSG00000074643.12	ENSMUST00000079312.9	ENSMUSP00000078292.3
ENSMUSG00000074643.12	ENSMUST00000140109.7	ENSMUSP00000121998.1
ENSMUSG00000074643.12	ENSMUST00000183733.7	ENSMUSP00000139230.1
ENSMUSG00000074643.12	ENSMUST00000136296.8	ENSMUSP00000122994.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	32.12	2.00e-25	109.00	IUUC-Ots-000026

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL.

Protein Sequence
(Fasta)

MAHCVTLVQL SVSCEHLIDK DIGSKSDPLC VLLQDVGGAW AELCRTERVR NCSSPEFSKT 60
LQIEYHFETV QKLRFGIYDI DNKTPELGDD DFLGGAECSL GQIVSSQTLT LPLMLKPGKP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTCCGGGAA CGCGGAGCGC CGGAGCGGGC GGGCGGCCAT TTTGTGAAGC GGCTGTGGAG 60
GTGTTGGCTG CAGTGGGCTC CGGGAAAGCC GTTCGGGCTG GGGCTGTCGG CCGCAGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR000008--C2_dom
IPR010734--Copine
IPR002035--VWF_A

PROSITE

PS50004--C2

Pfam

PF00168--C2
PF07002--Copine

SMART

SM00239--C2
SM00327--VWA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0004175--F:endopeptidase activity
GO:0051059--F:NF-kappaB binding
GO:0001786--F:phosphatidylserine binding
GO:0042803--F:protein homodimerization activity
GO:0071277--P:cellular response to calcium ion
GO:0043392--P:negative regulation of DNA binding
GO:0010629--P:negative regulation of gene expression
GO:1901223--P:negative regulation of NIK/NF-kappaB signaling
GO:1990138--P:neuron projection extension
GO:0045666--P:positive regulation of neuron differentiation
GO:0051897--P:positive regulation of protein kinase B signaling
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0006508--P:proteolysis
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:266692

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000336	Aegilops tauschii	34.55	1.00e-22	101.00
IUUC-Aml-002030	Ailuropoda melanoleuca	91.51	0.00e+00	981.00
IUUC-Atr-003148	Amborella trichopoda	32.35	1.00e-22	101.00
IUUC-Apl-003690	Anas platyrhynchos	68.93	0.00e+00	753.00
IUUC-Aca-005177	Anolis carolinensis	72.96	0.00e+00	815.00
IUUC-Ath-007080	Arabidopsis thaliana	30.10	9.00e-27	114.00
IUUC-Ang-009660	Aspergillus niger	27.71	7.40e-01	29.60
IUUC-Bol-016568	Brassica oleracea	31.87	2.00e-26	114.00
IUUC-Bra-017730	Brassica rapa	32.23	3.00e-27	115.00
IUUC-Cja-019806	Callithrix jacchus	91.25	0.00e+00	995.00
IUUC-Cfa-020719	Canis familiaris	91.89	0.00e+00	975.00
IUUC-Cpo-022547	Cavia porcellus	89.01	0.00e+00	982.00
IUUC-Csa-023455	Chlorocebus sabaeus	91.43	0.00e+00	996.00
IUUC-Cho-024698	Choloepus hoffmanni	58.71	1.00e-176	612.00
IUUC-Cin-025331	Ciona intestinalis	28.80	8.00e-17	80.90
IUUC-Csv-026082	Ciona savignyi	31.64	5.00e-19	87.80
IUUC-Dno-029223	Dasypus novemcinctus	86.55	0.00e+00	862.00
IUUC-Eeu-034962	Erinaceus europaeus	66.09	0.00e+00	706.00
IUUC-Fca-035987	Felis catus	91.51	0.00e+00	967.00
IUUC-Fal-036712	Ficedula albicollis	70.13	0.00e+00	771.00
IUUC-Gga-040253	Gallus gallus	73.40	0.00e+00	825.00
IUUC-Gma-043577	Glycine max	32.19	1.00e-27	117.00
IUUC-Ggo-045589	Gorilla gorilla	91.43	0.00e+00	996.00
IUUC-Hsa-046724	Homo sapiens	89.51	0.00e+00	985.00
IUUC-Hvu-047280	Hordeum vulgare	34.55	7.00e-23	101.00
IUUC-Lpe-051660	Leersia perrieri	31.87	1.00e-22	100.00
IUUC-Laf-054417	Loxodonta africana	91.31	0.00e+00	963.00
IUUC-Mcc-055340	Macaca mulatta	91.25	0.00e+00	996.00
IUUC-Mtr-058065	Medicago truncatula	31.91	2.00e-25	110.00
IUUC-Mga-059862	Meleagris gallopavo	72.95	0.00e+00	763.00
IUUC-Mmr-061707	Microcebus murinus	91.32	0.00e+00	964.00
IUUC-Mdo-061966	Monodelphis domestica	78.09	0.00e+00	848.00
IUUC-Mac-065151	Musa acuminata	33.21	3.00e-24	106.00
IUUC-Mpu-065680	Mustela putorius furo	91.31	0.00e+00	971.00
IUUC-Nle-069867	Nomascus leucogenys	91.99	0.00e+00	1003.00
IUUC-Ocu-074096	Oryctolagus cuniculus	90.73	0.00e+00	959.00
IUUC-Oin-079486	Oryza indica	32.04	9.00e-23	101.00
IUUC-Oga-088715	Otolemur garnettii	90.73	0.00e+00	967.00
IUUC-Oar-089570	Ovis aries	66.79	0.00e+00	726.00
IUUC-Ptr-090898	Pan troglodytes	91.01	0.00e+00	627.00
IUUC-Pan-092519	Papio anubis	91.43	0.00e+00	1005.00
IUUC-Psi-093065	Pelodiscus sinensis	73.16	0.00e+00	806.00
IUUC-Pma-094267	Petromyzon marinus	54.80	3.00e-168	584.00
IUUC-Ppa-095320	Physcomitrella patens	33.20	2.00e-23	103.00
IUUC-Pfo-097293	Poecilia formosa	66.73	0.00e+00	676.00
IUUC-Pop-099752	Populus trichocarpa	34.96	5.00e-26	112.00
IUUC-Pca-100224	Procavia capensis	62.83	0.00e+00	680.00
IUUC-Rno-104855	Rattus norvegicus	97.50	0.00e+00	1025.00
IUUC-Smo-108807	Selaginella moellendorffii	33.60	9.00e-22	97.80
IUUC-Sly-111136	Solanum lycopersicum	32.41	4.00e-26	112.00
IUUC-Stu-112115	Solanum tuberosum	33.33	8.00e-26	111.00
IUUC-Sar-113010	Sorex araneus	63.02	0.00e+00	668.00
IUUC-Sbi-114268	Sorghum bicolor	33.70	1.00e-25	111.00
IUUC-Ssc-115580	Sus scrofa	93.82	0.00e+00	979.00
IUUC-Tru-118245	Takifugu rubripes	66.48	0.00e+00	686.00
IUUC-Tsy-119089	Tarsius syrichta	66.42	0.00e+00	723.00
IUUC-Tca-121637	Theobroma cacao	33.33	1.00e-28	120.00
IUUC-Tae-123953	Triticum aestivum	34.55	8.00e-23	101.00
IUUC-Vvi-131538	Vitis vinifera	30.43	1.00e-26	114.00
IUUC-Xtr-132921	Xenopus tropicalis	57.81	7.00e-179	620.00
IUUC-Xma-133656	Xiphophorus maculatus	65.46	0.00e+00	711.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence