iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071527

Ensembl Protein ID

ENSONIP00000004712.1

UniProt Accession

I3J772; I3J772_ORENI

Genbank Protein ID

ENSONIP00000004712

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01034910

Gene Name

ube3a; LOC100698085

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000003746.1	ENSONIT00000004715.1	ENSONIP00000004712.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.50e-107	357.8	586	912

Active Site

Position(s)	Description	Evidence
881	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e  k  ++ np+s+    e++  ++++G++lg+a++++ +ld+
   Q: 586  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEHTKLFWF-NPSSF----ENEGQYTLIGIVLGLAIYNNCILDV 669
           689******************************************998888876.88888....6799********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfs.vseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+slke++e+ e ++ee ++ +tf+  +++++g++  ++L ++G++ipVtneN++e+v ++ 
   Q: 670  HFPMVVYRKLMGKKGTFRDLADANPVLYQSLKELLEY-EGSVEE-DMMITFQiSHTDLFGNALMYDLRENGDKIPVTNENRKEFVAQYS 756
           *************************************.556665.5999999445667******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           ey+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+ +l+++t+y+ggy++ds+ i+ Fwe+l++f +e+++ fLq
   Q: 757  EYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFLALEETTEYDGGYNRDSRIIKEFWETLHSFGEEQKRLFLQ 845
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d drlP+s+TCfn+L LPeYsske+l+e+Ll Ai+++kgF++
   Q: 846  FTTGTDRAPVGGLGKLK---MIIAKNGPDtDRLPTSHTCFNVLLLPEYSSKEKLRERLLKAITYAKGFGM 912
           *****************...8888866666**************************************97 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

DCECAPPQAE TSSAGGADRE LDQFPEQDSH FVTPQQSQQY SEIEHEEPEI ENPEASRMKR 60
AAAKHLIERY YHQLTEGCGN ESCSNSWCAS SVGFSRMDNN EAAVKALELY KVNAKLCDPH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNNAG GAGGACTGTG AGTGTGCGCC ACCACAGGCC GAGACAAGCT CCGCCGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	85.86	0.00e+00	1435.00
IUUC-Apl-003742	Anas platyrhynchos	87.14	0.00e+00	1457.00
IUUC-Aca-004873	Anolis carolinensis	86.74	0.00e+00	1463.00
IUUC-Ame-011166	Astyanax mexicanus	87.31	0.00e+00	1463.00
IUUC-Bta-013286	Bos taurus	85.68	0.00e+00	1409.00
IUUC-Cja-019707	Callithrix jacchus	84.65	0.00e+00	1436.00
IUUC-Cfa-020154	Canis familiaris	85.47	0.00e+00	1436.00
IUUC-Cpo-021292	Cavia porcellus	84.56	0.00e+00	1415.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.69	4.00e-82	298.00
IUUC-Csa-023378	Chlorocebus sabaeus	84.53	0.00e+00	1435.00
IUUC-Cho-025059	Choloepus hoffmanni	82.26	0.00e+00	1356.00
IUUC-Csv-026282	Ciona savignyi	45.34	0.00e+00	661.00
IUUC-Dre-027901	Danio rerio	85.68	0.00e+00	1446.00
IUUC-Dno-029320	Dasypus novemcinctus	85.70	0.00e+00	1439.00
IUUC-Dor-030756	Dipodomys ordii	91.67	0.00e+00	632.00
IUUC-Dme-032035	Drosophila melanogaster	43.41	3.00e-167	582.00
IUUC-Eca-033843	Equus caballus	85.86	0.00e+00	1410.00
IUUC-Eeu-035109	Erinaceus europaeus	84.44	0.00e+00	1390.00
IUUC-Fca-036344	Felis catus	85.58	0.00e+00	1435.00
IUUC-Fal-036747	Ficedula albicollis	87.14	0.00e+00	1457.00
IUUC-Gga-040399	Gallus gallus	87.25	0.00e+00	1459.00
IUUC-Gac-041933	Gasterosteus aculeatus	94.64	0.00e+00	1522.00
IUUC-Ggo-044804	Gorilla gorilla	84.65	0.00e+00	1436.00
IUUC-Hsa-045727	Homo sapiens	84.65	0.00e+00	1436.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	81.99	0.00e+00	1337.00
IUUC-Lch-050197	Latimeria chalumnae	84.80	0.00e+00	1447.00
IUUC-Loc-052743	Lepisosteus oculatus	88.17	0.00e+00	1493.00
IUUC-Lma-053245	Leptosphaeria maculans	34.57	6.00e-57	216.00
IUUC-Laf-053615	Loxodonta africana	84.57	0.00e+00	1432.00
IUUC-Mcc-054934	Macaca mulatta	84.53	0.00e+00	1435.00
IUUC-Meu-056061	Macropus eugenii	82.01	0.00e+00	1307.00
IUUC-Mga-059271	Meleagris gallopavo	87.19	0.00e+00	1450.00
IUUC-Mmr-061288	Microcebus murinus	86.40	0.00e+00	1444.00
IUUC-Mdo-062975	Monodelphis domestica	86.79	0.00e+00	1457.00
IUUC-Mmu-063674	Mus musculus	83.35	0.00e+00	1393.00
IUUC-Mpu-066568	Mustela putorius furo	85.93	0.00e+00	1444.00
IUUC-Mlu-067522	Myotis lucifugus	80.92	0.00e+00	1353.00
IUUC-Nle-069505	Nomascus leucogenys	84.65	0.00e+00	1436.00
IUUC-Opr-070570	Ochotona princeps	78.70	0.00e+00	1291.00
IUUC-Oan-073446	Ornithorhynchus anatinus	84.20	0.00e+00	936.00
IUUC-Ocu-074922	Oryctolagus cuniculus	84.61	0.00e+00	1429.00
IUUC-Ola-086996	Oryzias latipes	92.88	0.00e+00	1583.00
IUUC-Oga-088261	Otolemur garnettii	85.98	0.00e+00	1429.00
IUUC-Oar-090024	Ovis aries	85.68	0.00e+00	1409.00
IUUC-Ptr-090455	Pan troglodytes	84.65	0.00e+00	1436.00
IUUC-Pan-092509	Papio anubis	83.49	0.00e+00	1276.00
IUUC-Psi-092974	Pelodiscus sinensis	87.47	0.00e+00	1439.00
IUUC-Pma-094643	Petromyzon marinus	71.02	0.00e+00	1244.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.06	1.00e-57	219.00
IUUC-Pfo-096905	Poecilia formosa	90.47	0.00e+00	1607.00
IUUC-Pab-097840	Pongo abelii	83.90	0.00e+00	1390.00
IUUC-Pca-100869	Procavia capensis	84.15	0.00e+00	1417.00
IUUC-Pva-103040	Pteropus vampyrus	90.48	0.00e+00	627.00
IUUC-Rno-105453	Rattus norvegicus	83.12	0.00e+00	1395.00
IUUC-Sha-107651	Sarcophilus harrisii	86.79	0.00e+00	1457.00
IUUC-Sar-113293	Sorex araneus	86.45	0.00e+00	1443.00
IUUC-Ssc-115979	Sus scrofa	85.61	0.00e+00	1433.00
IUUC-Tgu-116901	Taeniopygia guttata	87.14	0.00e+00	1457.00
IUUC-Tru-118368	Takifugu rubripes	94.76	0.00e+00	1589.00
IUUC-Tsy-119516	Tarsius syrichta	82.01	0.00e+00	1323.00
IUUC-Tni-120143	Tetraodon nigroviridis	95.11	0.00e+00	1582.00
IUUC-Tbe-127484	Tupaia belangeri	80.22	0.00e+00	964.00
IUUC-Ttr-129078	Tursiops truncatus	85.51	0.00e+00	1418.00
IUUC-Vpa-130312	Vicugna pacos	77.42	0.00e+00	1194.00
IUUC-Xtr-132881	Xenopus tropicalis	85.13	0.00e+00	1449.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence