iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000032475.15	ENSMUST00000116522.7	ENSMUSP00000112221.1
ENSMUSG00000032475.15	ENSMUST00000112874.3	ENSMUSP00000108495.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-45	153.9	192	249

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +++vq+ly+++++nd+eL+++kGdv++viek e+d +W+k+ ++ +g  Gl+P+n+v+ 
   Q: 192  LHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKC-RKINGMVGLVPKNYVTI 249
           689**************************************.59*************85 PP

Organism

Mus musculus

Functional Description
(View)

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA (By similarity).

Protein Sequence
(Fasta)

MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF VPSNYVERKN 60
SARKASIVKN LKDTLGIGKV KRKPSVPDTA SPADDSFVDP GERLYDLNMP AFVKFNYMAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGCGCGC GCCCCGCCCC TCTCCGAGAG CTACGCGGCG GCGCAGCACA GGCCTCGTGC 60
GGTAACGGCA TCCGGGCAGC CGCGGTGGCG TCCCGGTGCG GTCCTCAGGT GACTGGAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0810--Translation regulation

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005913--C:cell-cell adherens junction
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0046875--F:ephrin receptor binding
GO:0071074--F:eukaryotic initiation factor eIF2 binding
GO:0019904--F:protein domain specific binding
GO:0004860--F:protein kinase inhibitor activity
GO:0005102--F:receptor binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation

KEGG

mmu:17973

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	98.41	0.00e+00	737.00
IUUC-Ame-011235	Astyanax mexicanus	78.36	0.00e+00	626.00
IUUC-Bta-013039	Bos taurus	98.41	0.00e+00	737.00
IUUC-Cja-019546	Callithrix jacchus	98.67	0.00e+00	732.00
IUUC-Cfa-020462	Canis familiaris	98.67	0.00e+00	739.00
IUUC-Cpo-022009	Cavia porcellus	98.41	0.00e+00	734.00
IUUC-Csa-023875	Chlorocebus sabaeus	98.94	0.00e+00	739.00
IUUC-Cho-024368	Choloepus hoffmanni	96.80	0.00e+00	650.00
IUUC-Csv-026046	Ciona savignyi	40.60	5.00e-72	265.00
IUUC-Dre-028407	Danio rerio	77.31	4.00e-178	617.00
IUUC-Dno-029593	Dasypus novemcinctus	98.40	2.00e-174	604.00
IUUC-Dor-030730	Dipodomys ordii	98.40	0.00e+00	644.00
IUUC-Dme-031846	Drosophila melanogaster	43.10	4.00e-92	332.00
IUUC-Ete-032906	Echinops telfairi	97.61	0.00e+00	726.00
IUUC-Eca-033378	Equus caballus	98.18	0.00e+00	638.00
IUUC-Eeu-034743	Erinaceus europaeus	88.33	0.00e+00	676.00
IUUC-Fca-035745	Felis catus	98.41	0.00e+00	778.00
IUUC-Gac-042245	Gasterosteus aculeatus	75.84	2.00e-159	555.00
IUUC-Ggo-045487	Gorilla gorilla	98.94	0.00e+00	739.00
IUUC-Hsa-045902	Homo sapiens	98.94	0.00e+00	739.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	99.20	0.00e+00	739.00
IUUC-Lch-050165	Latimeria chalumnae	82.49	0.00e+00	627.00
IUUC-Loc-052523	Lepisosteus oculatus	78.63	2.00e-179	621.00
IUUC-Laf-053845	Loxodonta africana	98.41	0.00e+00	736.00
IUUC-Meu-056139	Macropus eugenii	90.98	0.00e+00	666.00
IUUC-Mmr-061108	Microcebus murinus	87.27	3.00e-174	604.00
IUUC-Mdo-062258	Monodelphis domestica	93.90	0.00e+00	711.00
IUUC-Mpu-066093	Mustela putorius furo	98.14	0.00e+00	735.00
IUUC-Mlu-067193	Myotis lucifugus	98.41	0.00e+00	736.00
IUUC-Nle-069611	Nomascus leucogenys	98.94	0.00e+00	739.00
IUUC-Opr-070984	Ochotona princeps	97.67	3.00e-179	620.00
IUUC-Ont-072241	Oreochromis niloticus	75.64	2.00e-171	595.00
IUUC-Oan-072976	Ornithorhynchus anatinus	88.93	1.00e-166	578.00
IUUC-Ocu-073905	Oryctolagus cuniculus	99.47	0.00e+00	740.00
IUUC-Ola-086513	Oryzias latipes	74.36	6.00e-159	553.00
IUUC-Oga-088588	Otolemur garnettii	98.94	0.00e+00	738.00
IUUC-Oar-089973	Ovis aries	98.67	0.00e+00	739.00
IUUC-Ptr-090968	Pan troglodytes	98.94	0.00e+00	739.00
IUUC-Pan-092840	Papio anubis	98.72	3.00e-175	607.00
IUUC-Pfo-096057	Poecilia formosa	74.49	1.00e-169	588.00
IUUC-Pab-097807	Pongo abelii	98.67	0.00e+00	739.00
IUUC-Pca-100522	Procavia capensis	97.76	1.00e-173	601.00
IUUC-Pva-103083	Pteropus vampyrus	98.67	0.00e+00	738.00
IUUC-Rno-104839	Rattus norvegicus	97.08	0.00e+00	746.00
IUUC-Sha-107294	Sarcophilus harrisii	93.37	0.00e+00	704.00
IUUC-Sar-113675	Sorex araneus	96.82	0.00e+00	723.00
IUUC-Ssc-116442	Sus scrofa	97.61	0.00e+00	770.00
IUUC-Tru-118058	Takifugu rubripes	74.30	2.00e-168	584.00
IUUC-Tsy-119184	Tarsius syrichta	91.39	0.00e+00	631.00
IUUC-Tni-119974	Tetraodon nigroviridis	74.74	2.00e-157	548.00
IUUC-Ttr-129155	Tursiops truncatus	96.29	0.00e+00	732.00
IUUC-Vpa-130344	Vicugna pacos	98.41	0.00e+00	738.00
IUUC-Xtr-132372	Xenopus tropicalis	86.97	0.00e+00	656.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence