iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	4.60e-06	26.8	374	443

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 74   aglrseaaaapapapaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwkt 145
            gl   aa+a  p p     p       l+drlp+e +v+i++ ld+ el+++arvcrr+++la ++ lwk 
   Q: 374  NGLGGGAASAIGPPPWNRKGPFR--CGPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKV 443
           35555555555555444444433..34689*******************************99999999986 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MSHKTSNRRS SDLECPLASL GRNSNAVRDH YHHPHPLSSS PLDPQAYKMM SRKSPNPGLE 60
VAEALASRSS TPPSDQAGAS STAAAAAVLH MVQQKAATFE LRGRHSRPTE QQTSYGAHST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGTTGCCA TTTACCTGTC GACGCATCCA GGTGCCCGCG TGTCCCGGTG TCGTAGAAGC 60
GGATCAAACG GTCTCAAGGC GCCGCTCTGC GTTGCGTGCC TACGTGTCCT ACGGGTGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13516--LRR_6

SMART

SM00256--FBOX
SM00367--LRR_CC

Gene Ontology

GO:0045177--C:apical part of cell
GO:0005911--C:cell-cell junction
GO:0019005--C:SCF ubiquitin ligase complex
GO:0044257--P:cellular protein catabolic process
GO:0045926--P:negative regulation of growth
GO:0045571--P:negative regulation of imaginal disc growth
GO:0016567--P:protein ubiquitination
GO:0007449--P:proximal/distal pattern formation, imaginal disc
GO:0035330--P:regulation of hippo signaling
GO:0032880--P:regulation of protein localization
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG4221

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002298	Ailuropoda melanoleuca	49.21	8.00e-108	383.00
IUUC-Atr-002552	Amborella trichopoda	30.09	4.00e-31	129.00
IUUC-Apl-003410	Anas platyrhynchos	49.07	1.00e-108	385.00
IUUC-Aca-004422	Anolis carolinensis	47.88	2.00e-107	382.00
IUUC-Aly-006077	Arabidopsis lyrata	30.00	3.00e-30	125.00
IUUC-Ate-010306	Aspergillus terreus	25.95	4.00e-23	102.00
IUUC-Ame-010878	Astyanax mexicanus	47.38	9.00e-107	379.00
IUUC-Bta-013145	Bos taurus	49.21	6.00e-108	383.00
IUUC-Cja-019612	Callithrix jacchus	49.74	4.00e-109	387.00
IUUC-Cfa-020920	Canis familiaris	44.95	8.00e-108	382.00
IUUC-Cpo-022293	Cavia porcellus	49.21	5.00e-108	383.00
IUUC-Cre-022794	Chlamydomonas reinhardtii	27.92	1.00e-08	53.90
IUUC-Csa-024100	Chlorocebus sabaeus	49.47	1.00e-108	385.00
IUUC-Dre-028464	Danio rerio	46.96	2.00e-107	382.00
IUUC-Dno-028849	Dasypus novemcinctus	49.21	3.00e-108	384.00
IUUC-Dor-030835	Dipodomys ordii	54.19	2.00e-53	202.00
IUUC-Eca-034259	Equus caballus	49.21	1.00e-108	385.00
IUUC-Fca-035850	Felis catus	49.21	6.00e-108	383.00
IUUC-Fal-037009	Ficedula albicollis	49.34	9.00e-109	386.00
IUUC-Gmo-038560	Gadus morhua	39.19	4.00e-46	176.00
IUUC-Gga-040391	Gallus gallus	49.07	7.00e-109	386.00
IUUC-Gac-041464	Gasterosteus aculeatus	45.91	5.00e-100	357.00
IUUC-Gma-043454	Glycine max	30.58	4.00e-31	128.00
IUUC-Ggo-044556	Gorilla gorilla	49.21	3.00e-108	384.00
IUUC-Hsa-046685	Homo sapiens	49.47	4.00e-109	387.00
IUUC-Itr-048013	Ictidomys tridecemlineatus	49.47	7.00e-109	386.00
IUUC-Lch-050268	Latimeria chalumnae	48.41	2.00e-108	385.00
IUUC-Loc-051910	Lepisosteus oculatus	47.35	3.00e-105	374.00
IUUC-Laf-053599	Loxodonta africana	49.21	1.00e-107	382.00
IUUC-Mcc-055225	Macaca mulatta	49.47	4.00e-109	387.00
IUUC-Meu-056341	Macropus eugenii	49.74	1.00e-109	389.00
IUUC-Mtr-058356	Medicago truncatula	29.50	9.00e-30	124.00
IUUC-Mga-059525	Meleagris gallopavo	45.00	9.00e-107	379.00
IUUC-Mmr-060571	Microcebus murinus	49.74	1.00e-109	389.00
IUUC-Mdo-062229	Monodelphis domestica	50.00	1.00e-109	388.00
IUUC-Mmu-063408	Mus musculus	49.21	1.00e-109	389.00
IUUC-Mpu-065742	Mustela putorius furo	49.47	5.00e-109	387.00
IUUC-Mlu-067442	Myotis lucifugus	49.21	9.00e-108	382.00
IUUC-Nle-069404	Nomascus leucogenys	49.47	5.00e-109	387.00
IUUC-Opr-070457	Ochotona princeps	48.94	3.00e-108	384.00
IUUC-Ont-072288	Oreochromis niloticus	46.44	7.00e-102	363.00
IUUC-Oan-073492	Ornithorhynchus anatinus	50.13	1.00e-108	385.00
IUUC-Ocu-074513	Oryctolagus cuniculus	49.08	3.00e-107	381.00
IUUC-Ola-086573	Oryzias latipes	46.17	6.00e-101	360.00
IUUC-Oga-088674	Otolemur garnettii	48.94	5.00e-108	384.00
IUUC-Oar-090268	Ovis aries	48.94	4.00e-107	380.00
IUUC-Ptr-091375	Pan troglodytes	49.47	4.00e-109	387.00
IUUC-Pan-091683	Papio anubis	49.47	2.00e-108	385.00
IUUC-Psi-093199	Pelodiscus sinensis	49.21	4.00e-109	387.00
IUUC-Pma-094494	Petromyzon marinus	43.08	2.00e-76	278.00
IUUC-Pfo-097004	Poecilia formosa	46.44	3.00e-100	358.00
IUUC-Pab-098590	Pongo abelii	49.47	2.00e-108	385.00
IUUC-Pca-100228	Procavia capensis	48.94	3.00e-104	371.00
IUUC-Ppe-101524	Prunus persica	30.77	1.00e-32	133.00
IUUC-Pva-103166	Pteropus vampyrus	48.94	3.00e-106	378.00
IUUC-Pgr-103540	Puccinia graminis	32.97	2.00e-18	87.40
IUUC-Rno-104887	Rattus norvegicus	49.21	6.00e-109	386.00
IUUC-Sha-107379	Sarcophilus harrisii	49.74	1.00e-108	385.00
IUUC-Sly-111591	Solanum lycopersicum	31.36	2.00e-25	110.00
IUUC-Sar-113379	Sorex araneus	48.68	9.00e-108	382.00
IUUC-Ssc-115408	Sus scrofa	49.21	5.00e-108	383.00
IUUC-Tgu-117432	Taeniopygia guttata	48.68	1.00e-108	385.00
IUUC-Tru-117799	Takifugu rubripes	46.46	1.00e-100	359.00
IUUC-Tni-120688	Tetraodon nigroviridis	45.67	1.00e-99	355.00
IUUC-Tbe-127372	Tupaia belangeri	49.21	2.00e-106	378.00
IUUC-Ttr-128176	Tursiops truncatus	49.47	1.00e-108	386.00
IUUC-Vpa-130343	Vicugna pacos	52.26	3.00e-73	268.00
IUUC-Xtr-132187	Xenopus tropicalis	43.40	9.00e-110	389.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence