iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

DNA & RNA Element
CircNet
Protein-protein Interaction
IID	iRefIndex	Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
PhosphositePlus	dbPTM	HPRD	Phospho.ELM
UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.50e-10	41.8	175	228

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            ++l+d++++++ eL++k+Gdv++++     +++Wl+g  + +g  G+fP  Fv+ l+
   Q: 175  AEALFDFTGNSKLELNFKAGDVIFLL--SRINKDWLEG--TVRGATGIFPLSFVKILK 228
           689***********************..999*******..8*************9776 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.

Protein Sequence
(Fasta)

MAVAQQLRAE SDFEQLPDDV AISANIADIE EKRGFTSHFV FVIEVKTKGG SKYLIYRRYR 60
QFHALQSKLE ERFGPDSKSS ALACTLPTLP AKVYVGVKQE IAEMRIPALN AYMKSLLSLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGAGGAG CCTCTGCCAG ACTGGAGAGA AGCAGGCCTG AGCCTCCCCA AAGGCAGCTC 60
CTGGGGACTC CCAGGACCAC AGGCTGAGAC GAGACGCAGG GTGGCTGGAG GAAGTGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0161--Chronic granulomatous disease
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000919--NCF_P40
IPR000270--PB1_dom
IPR001683--Phox
IPR001452--SH3_domain

PROSITE

PS51745--PB1
PS50195--PX
PS50002--SH3

Pfam

PF00564--PB1
PF00787--PX
PF00018--SH3_1

PRINTS

PR00497--P40PHOX

SMART

SM00666--PB1
SM00312--PX
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0016020--C:membrane
GO:0043020--C:NADPH oxidase complex
GO:0032010--C:phagolysosome
GO:0005802--C:trans-Golgi network
GO:0005086--F:ARF guanyl-nucleotide exchange factor activity
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0046983--F:protein dimerization activity
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0045454--P:cell redox homeostasis
GO:0006955--P:immune response
GO:0055114--P:oxidation-reduction process
GO:0000302--P:response to reactive oxygen species
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016192--P:vesicle-mediated transport

KEGG

hsa:4689

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Eeu-035129	Erinaceus europaeus	64.73	4.00e-73	268.00
IUUC-Ggo-044667	Gorilla gorilla	99.14	0.00e+00	640.00
IUUC-Mmr-061065	Microcebus murinus	71.93	3.00e-131	461.00
IUUC-Opr-070204	Ochotona princeps	76.44	9.00e-143	499.00
IUUC-Pca-100312	Procavia capensis	63.79	8.00e-107	380.00
IUUC-Pva-102113	Pteropus vampyrus	81.09	1.00e-155	542.00
IUUC-Tsy-119537	Tarsius syrichta	77.56	2.00e-100	358.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence