iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100225.17	ENST00000266087.11	ENSP00000266087.7
ENSG00000100225.17	ENST00000425028.5	ENSP00000395823.1
ENSG00000100225.17	ENST00000452138.3	ENSP00000388547.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	18495667; 16510124

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.0044	18.7	325	375

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 96   egpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           + pd   l  lp+e+ ++i++lld +++l+++ vcr + ++++++ lw+ +
   Q: 325  NLPDVFGLVVLPLELKLRIFRLLDVRSVLSLSAVCRDLFTASNDPLLWRFL 375
           6688888999**************************************865 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.

Protein Sequence
(Fasta)

MRLRVRLLKR TWPLEVPETE PTLGHLRSHL RQSLLCTWGY SSNTRFTITL NYKDPLTGDE 60
ETLASYGIVS GDLICLILQD DIPAPNIPSS TDSEHSSLQN NEQPSLATSS NQTSMQDEQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGCTCTCA GGCAGCGCCG TTGCGCGCGG AGTCATCGAT CGGCCGACCC CGAGAGGCCC 60
GGTTCCTTTA GGCCGCCTGC CCGCCTCCAG CTCTCGGGGT CGGCTCCAGG AGGCGCCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0488--Methylation
KW-0496--Mitochondrion
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0908--Parkinsonism
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR021625--PI31_Prot_N
IPR029071--Ubiquitin-rel_dom

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF11566--PI31_Prot_N

SMART

SM00256--FBOX

Gene Ontology

GO:0097414--C:classical Lewy body
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0097409--C:glial cytoplasmic inclusion
GO:1990037--C:Lewy body core
GO:1990038--C:Lewy body corona
GO:0097462--C:Lewy neurite
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0046982--F:protein heterodimerization activity
GO:0019901--F:protein kinase binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000422--P:mitophagy
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000134--P:negative regulation of G1/S transition of mitotic cell cycle
GO:1903208--P:negative regulation of hydrogen peroxide-induced neuron death
GO:0045620--P:negative regulation of lymphocyte differentiation
GO:1903204--P:negative regulation of oxidative stress-induced neuron death
GO:1903599--P:positive regulation of mitophagy
GO:0000209--P:protein polyubiquitination
GO:0006626--P:protein targeting to mitochondrion
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0040012--P:regulation of locomotion
GO:0010975--P:regulation of neuron projection development
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:25793

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000290	Aegilops tauschii	20.00	2.00e-04	40.00
IUUC-Aml-001880	Ailuropoda melanoleuca	79.13	0.00e+00	642.00
IUUC-Atr-003003	Amborella trichopoda	24.26	5.00e-13	69.30
IUUC-Apl-003234	Anas platyrhynchos	62.76	1.00e-165	575.00
IUUC-Aca-004673	Anolis carolinensis	58.10	1.00e-147	516.00
IUUC-Ath-007055	Arabidopsis thaliana	24.56	4.00e-10	59.30
IUUC-Ame-011733	Astyanax mexicanus	41.57	4.00e-69	255.00
IUUC-Bta-013386	Bos taurus	78.78	0.00e+00	726.00
IUUC-Bdi-014029	Brachypodium distachyon	21.45	4.00e-05	43.10
IUUC-Bol-015733	Brassica oleracea	26.49	6.00e-14	72.00
IUUC-Bra-016639	Brassica rapa	23.35	1.00e-09	58.20
IUUC-Cja-019301	Callithrix jacchus	89.66	0.00e+00	920.00
IUUC-Cfa-020474	Canis familiaris	78.59	0.00e+00	744.00
IUUC-Cpo-021958	Cavia porcellus	73.19	0.00e+00	761.00
IUUC-Csa-023971	Chlorocebus sabaeus	95.59	0.00e+00	949.00
IUUC-Cho-024677	Choloepus hoffmanni	81.14	1.00e-130	459.00
IUUC-Cin-025781	Ciona intestinalis	29.90	3.00e-47	183.00
IUUC-Csv-025989	Ciona savignyi	26.84	6.00e-20	91.30
IUUC-Dre-027820	Danio rerio	42.05	6.00e-35	142.00
IUUC-Dno-029936	Dasypus novemcinctus	74.76	0.00e+00	728.00
IUUC-Dor-030716	Dipodomys ordii	81.33	0.00e+00	689.00
IUUC-Ete-032853	Echinops telfairi	62.64	2.00e-123	436.00
IUUC-Eca-034267	Equus caballus	83.64	0.00e+00	693.00
IUUC-Eeu-035344	Erinaceus europaeus	78.63	4.00e-103	368.00
IUUC-Fca-035849	Felis catus	78.29	0.00e+00	725.00
IUUC-Fal-037612	Ficedula albicollis	63.47	6.00e-155	540.00
IUUC-Gmo-039634	Gadus morhua	48.47	3.00e-19	89.00
IUUC-Gga-041190	Gallus gallus	63.00	1.00e-167	583.00
IUUC-Gac-042001	Gasterosteus aculeatus	38.41	7.00e-67	248.00
IUUC-Gma-044390	Glycine max	22.11	2.00e-05	43.90
IUUC-Ggo-044544	Gorilla gorilla	98.85	0.00e+00	983.00
IUUC-Itr-048160	Ictidomys tridecemlineatus	82.17	0.00e+00	690.00
IUUC-Lch-049937	Latimeria chalumnae	51.70	2.00e-109	389.00
IUUC-Loc-052097	Lepisosteus oculatus	43.00	5.00e-85	308.00
IUUC-Laf-053445	Loxodonta africana	78.54	0.00e+00	731.00
IUUC-Meu-055942	Macropus eugenii	59.63	8.00e-139	487.00
IUUC-Mtr-058475	Medicago truncatula	24.14	1.00e-07	51.20
IUUC-Mga-059897	Meleagris gallopavo	64.04	2.00e-122	432.00
IUUC-Mmr-061491	Microcebus murinus	83.94	0.00e+00	794.00
IUUC-Mdo-062549	Monodelphis domestica	68.18	0.00e+00	685.00
IUUC-Mmu-064312	Mus musculus	72.90	0.00e+00	773.00
IUUC-Mac-064591	Musa acuminata	23.53	2.00e-07	50.80
IUUC-Mlu-067947	Myotis lucifugus	79.92	0.00e+00	674.00
IUUC-Nle-069189	Nomascus leucogenys	94.83	0.00e+00	933.00
IUUC-Opr-070340	Ochotona princeps	59.66	7.00e-61	228.00
IUUC-Ont-071633	Oreochromis niloticus	42.80	2.00e-79	289.00
IUUC-Oan-073153	Ornithorhynchus anatinus	67.08	3.00e-145	508.00
IUUC-Ocu-074367	Oryctolagus cuniculus	81.95	0.00e+00	650.00
IUUC-Oba-075835	Oryza barthii	24.55	8.00e-06	45.40
IUUC-Obr-076729	Oryza brachyantha	23.19	9.00e-07	48.50
IUUC-Ome-081758	Oryza meridionalis	21.21	3.00e-05	44.70
IUUC-Opu-083777	Oryza punctata	23.89	1.00e-05	46.20
IUUC-Oru-084872	Oryza rufipogon	24.55	1.00e-05	45.80
IUUC-Osa-086001	Oryza sativa	24.55	5.00e-06	46.20
IUUC-Ola-087349	Oryzias latipes	39.16	2.00e-62	233.00
IUUC-Oga-088097	Otolemur garnettii	83.33	0.00e+00	779.00
IUUC-Oar-089633	Ovis aries	79.51	0.00e+00	727.00
IUUC-Ptr-091253	Pan troglodytes	98.85	0.00e+00	978.00
IUUC-Pan-092709	Papio anubis	95.40	0.00e+00	947.00
IUUC-Pma-094225	Petromyzon marinus	34.00	2.00e-62	233.00
IUUC-Ppa-095848	Physcomitrella patens	21.70	9.00e-06	45.40
IUUC-Pfo-096303	Poecilia formosa	41.18	5.00e-62	231.00
IUUC-Pab-098160	Pongo abelii	97.71	0.00e+00	879.00
IUUC-Pop-099047	Populus trichocarpa	24.22	9.00e-11	62.00
IUUC-Pca-100918	Procavia capensis	75.21	3.00e-125	442.00
IUUC-Ppe-101570	Prunus persica	24.25	3.00e-08	53.50
IUUC-Pva-103142	Pteropus vampyrus	83.40	0.00e+00	711.00
IUUC-Rno-105527	Rattus norvegicus	72.47	0.00e+00	748.00
IUUC-Sce-106144	Saccharomyces cerevisiae	26.09	3.80e-02	33.50
IUUC-Sha-106501	Sarcophilus harrisii	67.70	8.00e-165	573.00
IUUC-Smo-108975	Selaginella moellendorffii	26.83	4.00e-08	50.40
IUUC-Sly-111386	Solanum lycopersicum	23.80	7.00e-10	58.90
IUUC-Stu-112530	Solanum tuberosum	24.95	1.00e-15	77.80
IUUC-Sar-113529	Sorex araneus	78.88	0.00e+00	701.00
IUUC-Sbi-114203	Sorghum bicolor	21.64	1.00e-06	47.80
IUUC-Ssc-116130	Sus scrofa	81.97	0.00e+00	773.00
IUUC-Tgu-116850	Taeniopygia guttata	62.78	5.00e-156	544.00
IUUC-Tru-117759	Takifugu rubripes	38.34	2.00e-66	246.00
IUUC-Tni-120308	Tetraodon nigroviridis	38.23	1.00e-56	214.00
IUUC-Tca-120980	Theobroma cacao	26.42	3.00e-14	73.60
IUUC-Tae-123742	Triticum aestivum	19.68	2.00e-03	37.40
IUUC-Tbe-127805	Tupaia belangeri	68.33	1.00e-151	529.00
IUUC-Ttr-129004	Tursiops truncatus	81.37	0.00e+00	721.00
IUUC-Uma-129573	Ustilago maydis	28.00	3.70e-01	30.00
IUUC-Vpa-130452	Vicugna pacos	84.02	0.00e+00	692.00
IUUC-Vvi-131289	Vitis vinifera	24.66	2.00e-12	67.80
IUUC-Xtr-132447	Xenopus tropicalis	47.44	1.00e-111	396.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence