iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000004637.7	ENSRNOT00000077577.1	ENSRNOP00000070310.1
ENSRNOG00000004637.7	ENSRNOT00000006366.7	ENSRNOP00000006366.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	72.47	0.00e+00	748.00	IUUC-Hsa-046348

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity).

Protein Sequence
(Fasta)

MKLRVRLQKR TQPLEVPESE PTLGQLRAHL IQDLLPTLGF SSDTRFAITL NNKDALTGDE 60
ETLASYGIVS GDLICLVLED EMPAPNLPSS TDSEHSSLQN NDQPPLAATS SQANIPDEQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCACCGATAG AGAAGCGCAG GCGCTCGGCA CTCGGCTCGA GCAGAAGGCT CTAGGGGGCG 60
TGGTGGAGAG AGCGGCGAGC TGGGATTCCT CAGGCGCGCA GGCCCGGAGC TACTTGCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0496--Mitochondrion
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR021625--PI31_Prot_N

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF11566--PI31_Prot_N

Gene Ontology

GO:0097414--C:classical Lewy body
GO:0005829--C:cytosol
GO:0097409--C:glial cytoplasmic inclusion
GO:1990037--C:Lewy body core
GO:1990038--C:Lewy body corona
GO:0097462--C:Lewy neurite
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0000422--P:mitophagy
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000134--P:negative regulation of G1/S transition of mitotic cell cycle
GO:0045620--P:negative regulation of lymphocyte differentiation
GO:1901215--P:negative regulation of neuron death
GO:1903204--P:negative regulation of oxidative stress-induced neuron death
GO:1903599--P:positive regulation of mitophagy
GO:0006626--P:protein targeting to mitochondrion
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0040012--P:regulation of locomotion
GO:0010975--P:regulation of neuron projection development
GO:0031647--P:regulation of protein stability

KEGG

rno:366854

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000290	Aegilops tauschii	22.77	2.00e-05	43.10
IUUC-Aml-001880	Ailuropoda melanoleuca	74.38	3.00e-173	601.00
IUUC-Atr-003003	Amborella trichopoda	25.72	4.00e-10	59.30
IUUC-Apl-003234	Anas platyrhynchos	60.70	4.00e-152	531.00
IUUC-Aca-004673	Anolis carolinensis	55.41	1.00e-133	469.00
IUUC-Ath-007055	Arabidopsis thaliana	23.17	2.00e-10	60.50
IUUC-Ame-011733	Astyanax mexicanus	47.24	8.00e-60	224.00
IUUC-Bta-013386	Bos taurus	72.08	0.00e+00	665.00
IUUC-Bdi-014029	Brachypodium distachyon	19.92	8.00e-05	42.00
IUUC-Bol-015733	Brassica oleracea	25.71	2.00e-12	67.00
IUUC-Bra-016639	Brassica rapa	22.99	1.00e-07	51.20
IUUC-Cja-019301	Callithrix jacchus	75.14	0.00e+00	776.00
IUUC-Cfa-020474	Canis familiaris	74.00	0.00e+00	695.00
IUUC-Cpo-021958	Cavia porcellus	70.15	0.00e+00	736.00
IUUC-Csa-023971	Chlorocebus sabaeus	73.23	0.00e+00	723.00
IUUC-Cho-024677	Choloepus hoffmanni	70.82	5.00e-114	404.00
IUUC-Cin-025781	Ciona intestinalis	29.37	3.00e-45	176.00
IUUC-Csv-025989	Ciona savignyi	29.65	1.00e-26	113.00
IUUC-Cgl-026585	Colletotrichum gloeosporioides	33.33	2.30e+00	28.50
IUUC-Dre-027820	Danio rerio	36.28	3.00e-40	159.00
IUUC-Dno-029936	Dasypus novemcinctus	68.04	0.00e+00	671.00
IUUC-Dor-030716	Dipodomys ordii	75.88	0.00e+00	671.00
IUUC-Ete-032853	Echinops telfairi	63.42	7.00e-108	384.00
IUUC-Eca-034267	Equus caballus	76.19	0.00e+00	634.00
IUUC-Eeu-035344	Erinaceus europaeus	68.95	6.00e-90	324.00
IUUC-Fca-035849	Felis catus	71.54	0.00e+00	654.00
IUUC-Fal-037612	Ficedula albicollis	58.78	8.00e-141	493.00
IUUC-Gmo-039634	Gadus morhua	50.92	2.00e-20	92.80
IUUC-Gga-041190	Gallus gallus	59.09	2.00e-152	531.00
IUUC-Gac-042001	Gasterosteus aculeatus	39.39	1.00e-70	260.00
IUUC-Ggo-044544	Gorilla gorilla	72.47	0.00e+00	716.00
IUUC-Hsa-046348	Homo sapiens	72.47	0.00e+00	716.00
IUUC-Itr-048160	Ictidomys tridecemlineatus	77.43	0.00e+00	657.00
IUUC-Lch-049937	Latimeria chalumnae	49.18	1.00e-97	350.00
IUUC-Loc-052097	Lepisosteus oculatus	46.92	2.00e-87	315.00
IUUC-Lma-052967	Leptosphaeria maculans	33.33	1.00e-04	41.20
IUUC-Laf-053445	Loxodonta africana	72.80	0.00e+00	688.00
IUUC-Meu-055942	Macropus eugenii	54.24	2.00e-114	406.00
IUUC-Mtr-058475	Medicago truncatula	24.58	2.00e-07	50.40
IUUC-Mga-059897	Meleagris gallopavo	62.28	1.00e-114	406.00
IUUC-Mmr-061491	Microcebus murinus	77.25	0.00e+00	728.00
IUUC-Mdo-062549	Monodelphis domestica	64.02	4.00e-176	611.00
IUUC-Mmu-064312	Mus musculus	90.25	0.00e+00	967.00
IUUC-Mac-064591	Musa acuminata	23.87	1.00e-06	48.10
IUUC-Mlu-067947	Myotis lucifugus	72.54	7.00e-179	620.00
IUUC-Nle-069189	Nomascus leucogenys	73.04	0.00e+00	721.00
IUUC-Opr-070340	Ochotona princeps	54.47	1.00e-52	201.00
IUUC-Ont-071633	Oreochromis niloticus	41.90	2.00e-79	289.00
IUUC-Oan-073153	Ornithorhynchus anatinus	64.14	2.00e-133	469.00
IUUC-Ocu-074367	Oryctolagus cuniculus	77.80	4.00e-178	617.00
IUUC-Oba-075835	Oryza barthii	21.13	1.00e-04	41.20
IUUC-Obr-076729	Oryza brachyantha	21.79	1.00e-05	44.30
IUUC-Ome-081758	Oryza meridionalis	21.89	1.00e-03	39.30
IUUC-Opu-083777	Oryza punctata	23.32	5.00e-05	43.90
IUUC-Ola-087349	Oryzias latipes	41.63	7.00e-68	251.00
IUUC-Oga-088097	Otolemur garnettii	75.29	0.00e+00	708.00
IUUC-Oar-089633	Ovis aries	73.06	0.00e+00	668.00
IUUC-Ptr-091253	Pan troglodytes	72.28	0.00e+00	712.00
IUUC-Pan-092709	Papio anubis	73.04	0.00e+00	720.00
IUUC-Pma-094225	Petromyzon marinus	37.75	1.00e-73	270.00
IUUC-Ppa-095848	Physcomitrella patens	23.49	6.00e-08	52.80
IUUC-Pfo-096303	Poecilia formosa	43.67	3.00e-67	249.00
IUUC-Pab-098160	Pongo abelii	72.61	0.00e+00	656.00
IUUC-Pop-099047	Populus trichocarpa	25.24	5.00e-12	65.90
IUUC-Pca-100918	Procavia capensis	71.27	3.00e-118	419.00
IUUC-Ppe-101570	Prunus persica	23.26	1.00e-10	61.20
IUUC-Pva-103142	Pteropus vampyrus	74.90	0.00e+00	650.00
IUUC-Sha-106501	Sarcophilus harrisii	60.08	1.00e-144	506.00
IUUC-Smo-108975	Selaginella moellendorffii	24.39	7.00e-08	49.70
IUUC-Sly-111386	Solanum lycopersicum	23.98	2.00e-09	57.40
IUUC-Stu-112530	Solanum tuberosum	25.15	2.00e-17	84.00
IUUC-Sar-113529	Sorex araneus	70.81	0.00e+00	640.00
IUUC-Ssc-116130	Sus scrofa	75.14	0.00e+00	716.00
IUUC-Tgu-116850	Taeniopygia guttata	57.26	3.00e-141	495.00
IUUC-Tru-117759	Takifugu rubripes	38.77	8.00e-69	254.00
IUUC-Tni-120308	Tetraodon nigroviridis	38.51	9.00e-56	211.00
IUUC-Tca-120980	Theobroma cacao	26.07	5.00e-14	72.40
IUUC-Tae-123742	Triticum aestivum	25.32	3.00e-06	47.00
IUUC-Tur-126713	Triticum urartu	25.83	1.00e-05	43.50
IUUC-Tbe-127805	Tupaia belangeri	63.12	8.00e-139	486.00
IUUC-Ttr-129004	Tursiops truncatus	74.69	0.00e+00	660.00
IUUC-Vpa-130452	Vicugna pacos	76.97	0.00e+00	641.00
IUUC-Vvi-131289	Vitis vinifera	25.06	2.00e-14	74.30
IUUC-Xtr-132447	Xenopus tropicalis	47.63	2.00e-113	402.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence