iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046684

Ensembl Protein ID

ENSP00000317327.6

UniProt Accession

P57075; G5E9E4; Q6HA34; Q6HA35; Q6ISI6; Q6ISK3; Q6ISS9; UBS3A_HUMAN

Genbank Protein ID

CAB91543.1; AAP80731.1; AAP80738.1; EAX09560.1; AAH69357.1; AAH69483.1; AAH69511.1; ENSP00000291535

Protein Name

Ubiquitin-associated and SH3 domain-containing protein A; Cbl-interacting protein 4; Suppressor of T-cell receptor signaling 2; T-cell ubiquitin ligand 1

Genbank Nucleotide ID

AJ277750; AF520809; AF521702; AP001746; BC069357; BC069483; BC069511; BC069577

Gene Name

UBASH3A; STS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000160185.14	ENST00000291535.11	ENSP00000291535.6
ENSG00000160185.14	ENST00000635325.1	ENSP00000489463.1
ENSG00000160185.14	ENST00000319294.10	ENSP00000317327.6
ENSG00000160185.14	ENST00000398367.1	ENSP00000381408.1
ENSG00000160185.14	ENST00000473381.1	ENSP00000489235.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	15159412; 17599067

Classification

Family	E-value	Score	Start	End
UBD/SH3	1.60e-15	58.5	280	340
UBD/Alpha-Helix/UBA	3.10e-07	31.9	22	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi..ekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++l++y++qn deLtl  Gd ++v   +++e +egW+ g ++ +g+rG++Pen++ +++
   Q: 280  TLRALFQYKPQNVDELTLSPGDYIFVDptQQDEASEGWVIGISQRTGCRGFLPENYTDRAS 340
           689***********************9989999************************9986 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
            ++le l +MGF+ ++al+aL+a+  +++e+A+++L+d+
   Q: 22   PSLLEPLLAMGFPVHTALKALAATgRKTAEEALAWLHDH 60
           6899********************************997 PP

Organism

Homo sapiens

Functional Description
(View)

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Protein Sequence
(Fasta)

MAAGETQLYA KVSNKLKSRS SPSLLEPLLA MGFPVHTALK ALAATGRKTA EEALAWLHDH 60
CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESKRQCA KNRAHEVFPH VTLCDFFTCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAAGTCA ATGAATGACT GAAAGAACCA GTAAGTTTTC CAGCAATCCG AGACAATAGA 60
TAGAGTGGGG TTTAATGTCT TGTTCACAGA CAAGGAGACT GGGATCCAGG GTGGGTCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR009097--cNuc_Pdiesterase
IPR013078--His_Pase_superF_clade-1
IPR029033--His_PPase_superfam
IPR001452--SH3_domain
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS50002--SH3
PS50030--UBA

Pfam

PF00300--His_Phos_1
PF14604--SH3_9

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0050860--P:negative regulation of T cell receptor signaling pathway
GO:0001817--P:regulation of cytokine production

KEGG

hsa:53347

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001941	Ailuropoda melanoleuca	80.36	0.00e+00	1107.00
IUUC-Atr-003098	Amborella trichopoda	29.41	6.00e-08	52.00
IUUC-Apl-003555	Anas platyrhynchos	62.67	0.00e+00	878.00
IUUC-Aca-004356	Anolis carolinensis	58.41	0.00e+00	671.00
IUUC-Bgr-012101	Blumeria graminis	32.52	4.00e-13	68.90
IUUC-Bta-012798	Bos taurus	77.68	0.00e+00	1056.00
IUUC-Bol-015778	Brassica oleracea	25.91	7.00e-06	44.30
IUUC-Cja-018791	Callithrix jacchus	84.92	0.00e+00	1090.00
IUUC-Cfa-020366	Canis familiaris	80.79	0.00e+00	1075.00
IUUC-Cpo-022474	Cavia porcellus	75.83	0.00e+00	1001.00
IUUC-Csa-023131	Chlorocebus sabaeus	92.13	0.00e+00	1217.00
IUUC-Cho-024803	Choloepus hoffmanni	70.32	4.00e-125	442.00
IUUC-Cme-027186	Cyanidioschyzon merolae	26.76	7.00e-12	64.30
IUUC-Dno-028890	Dasypus novemcinctus	72.74	0.00e+00	975.00
IUUC-Dor-031140	Dipodomys ordii	73.93	1.00e-152	533.00
IUUC-Dse-031474	Dothistroma septosporum	26.16	1.00e-09	57.00
IUUC-Ete-032656	Echinops telfairi	76.42	0.00e+00	660.00
IUUC-Eca-033634	Equus caballus	82.33	0.00e+00	1105.00
IUUC-Fca-035845	Felis catus	79.76	0.00e+00	1086.00
IUUC-Fal-037247	Ficedula albicollis	60.97	0.00e+00	834.00
IUUC-Gga-040276	Gallus gallus	62.99	0.00e+00	811.00
IUUC-Gma-044050	Glycine max	25.13	2.00e-06	46.60
IUUC-Ggo-045383	Gorilla gorilla	98.94	0.00e+00	1331.00
IUUC-Itr-048202	Ictidomys tridecemlineatus	78.85	0.00e+00	1046.00
IUUC-Lch-049841	Latimeria chalumnae	54.46	0.00e+00	657.00
IUUC-Lma-053306	Leptosphaeria maculans	28.31	4.00e-10	58.90
IUUC-Laf-053867	Loxodonta africana	76.28	0.00e+00	994.00
IUUC-Mcc-055524	Macaca mulatta	94.70	0.00e+00	1264.00
IUUC-Meu-056469	Macropus eugenii	63.83	4.00e-157	548.00
IUUC-Mga-059265	Meleagris gallopavo	61.61	0.00e+00	805.00
IUUC-Mmr-061107	Microcebus murinus	80.24	0.00e+00	1055.00
IUUC-Mdo-062508	Monodelphis domestica	69.70	0.00e+00	946.00
IUUC-Mmu-063613	Mus musculus	78.40	0.00e+00	1029.00
IUUC-Mpu-066673	Mustela putorius furo	78.31	0.00e+00	1040.00
IUUC-Mlu-068057	Myotis lucifugus	81.29	0.00e+00	1107.00
IUUC-Nle-070135	Nomascus leucogenys	96.79	0.00e+00	1221.00
IUUC-Oan-073094	Ornithorhynchus anatinus	66.10	0.00e+00	796.00
IUUC-Ocu-074819	Oryctolagus cuniculus	76.44	0.00e+00	1032.00
IUUC-Oga-088835	Otolemur garnettii	80.73	0.00e+00	1078.00
IUUC-Oar-089742	Ovis aries	75.83	0.00e+00	1013.00
IUUC-Ptr-091345	Pan troglodytes	98.64	0.00e+00	1290.00
IUUC-Pan-092316	Papio anubis	96.37	0.00e+00	1290.00
IUUC-Pab-098009	Pongo abelii	97.75	0.00e+00	1245.00
IUUC-Pca-100920	Procavia capensis	66.09	4.00e-125	441.00
IUUC-Ppe-101806	Prunus persica	24.62	8.00e-07	47.80
IUUC-Pva-102692	Pteropus vampyrus	79.23	0.00e+00	661.00
IUUC-Pyt-104727	Pyrenophora triticirepentis	26.16	9.00e-08	50.80
IUUC-Rno-106073	Rattus norvegicus	77.64	0.00e+00	1043.00
IUUC-Sha-106789	Sarcophilus harrisii	69.76	0.00e+00	966.00
IUUC-Smo-109333	Selaginella moellendorffii	34.26	4.00e-07	48.50
IUUC-Sly-111172	Solanum lycopersicum	29.52	5.00e-05	41.60
IUUC-Stu-112768	Solanum tuberosum	29.63	4.00e-05	42.00
IUUC-Ssc-115747	Sus scrofa	78.55	0.00e+00	1026.00
IUUC-Tgu-116653	Taeniopygia guttata	61.52	0.00e+00	825.00
IUUC-Tsy-119559	Tarsius syrichta	76.90	0.00e+00	915.00
IUUC-Tca-121384	Theobroma cacao	30.84	2.00e-04	39.70
IUUC-Tbe-127815	Tupaia belangeri	73.22	0.00e+00	959.00
IUUC-Ttr-129181	Tursiops truncatus	78.77	0.00e+00	675.00
IUUC-Vda-129751	Verticillium dahliae	25.63	7.00e-08	51.60
IUUC-Vpa-130759	Vicugna pacos	51.22	1.00e-101	363.00
IUUC-Yli-134663	Yarrowia lipolytica	28.85	5.00e-07	49.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence