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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046452
UUCD1 version UUC-HoS-00437
Ensembl Protein ID ENSP00000417601.1
UniProt Accession Q9UKC9; B4DQV0; E9PD06; Q6IAN3; Q9NVQ8; Q9UK27; Q9UKA5; Q9Y3Y9; FBXL2_HUMAN
Genbank Protein ID AAF04510.1; AAF03128.1; AAD56248.1; BAA91691.1; BAG61062.1; CAG33402.1; AAH31556.1; CAB43222.1
Protein Name F-box/LRR-repeat protein 2; F-box and leucine-rich repeat protein 2; F-box protein FBL2/FBL3
Genbank Nucleotide ID AF174589; AF176518; AF186273; AK001438; AK298967; CR457121; AC122176; AL049953
Gene Name FBXL2; FBL2; FBL3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000153558.13 ENST00000484457.5 ENSP00000417601.1
ENSG00000153558.13 ENST00000435207.5 ENSP00000411484.1
ENSG00000153558.13 ENST00000432809.5 ENSP00000411273.1
ENSG00000153558.13 ENST00000451636.5 ENSP00000416332.1
ENSG00000153558.13 ENST00000425973.5 ENSP00000405084.1
ENSG00000153558.13 ENST00000507198.5 ENSP00000426163.1
ENSG00000153558.13 ENST00000422741.5 ENSP00000406737.1
ENSG00000153558.13 ENST00000421391.5 ENSP00000408895.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 21343341; 26037928
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00076 21.2 11 55
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 102  lldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           + ++lp+e+l++i+++ld  +l+r+a++++ w+ la + + w+++
   Q: 11   INKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRI 55
           5689*****************************888778888875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).
 Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).
Protein Sequence
(Fasta)
MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS NWQRIDLFNF 60
QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA QNCRNIEHLN LNGCTKITDS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046452|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TATTATAACA ACTCATTGGA AGCTTGAAGC AGATAGAATG GAATCTGAGC AGTAGCTACT 60
TCAGGTGCTG GGGTGAGTGT CGTTTTATCC TTTTAAATTC TTGTTATTGG TAATTTAAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046452|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0106--Calcium
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-0433--Leucine-rich repeat
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0621--Polymorphism
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
PF13516--LRR_6
SMART

SM00256--FBOX
SM00367--LRR_CC
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0036312--F:phosphatidylinositol 3-kinase regulatory subunit binding
GO:0019903--F:protein phosphatase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0006513--P:protein monoubiquitination
GO:0016567--P:protein ubiquitination
GO:0006508--P:proteolysis
GO:0010506--P:regulation of autophagy
GO:0014066--P:regulation of phosphatidylinositol 3-kinase signaling
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process
KEGG hsa:25827
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000558 Aegilops tauschii 29.30 1.00e-24 107.00
IUUC-Aml-001591 Ailuropoda melanoleuca 98.58 0.00e+00 840.00
IUUC-Atr-002443 Amborella trichopoda 31.48 5.00e-37 148.00
IUUC-Apl-004140 Anas platyrhynchos 91.04 0.00e+00 765.00
IUUC-Aly-006077 Arabidopsis lyrata 28.45 1.00e-36 148.00
IUUC-Ath-007544 Arabidopsis thaliana 28.45 1.00e-36 148.00
IUUC-Acl-008241 Aspergillus clavatus 29.09 8.00e-41 162.00
IUUC-Afl-008737 Aspergillus flavus 30.37 2.00e-39 157.00
IUUC-Ani-009150 Aspergillus nidulans 27.65 2.00e-34 141.00
IUUC-Ang-009576 Aspergillus niger 30.22 1.00e-41 164.00
IUUC-Aor-010026 Aspergillus oryzae 30.37 2.00e-39 157.00
IUUC-Ate-010557 Aspergillus terreus 29.03 1.00e-42 168.00
IUUC-Ame-011331 Astyanax mexicanus 81.28 0.00e+00 723.00
IUUC-Bgr-012170 Blumeria graminis 30.05 1.00e-36 147.00
IUUC-Bta-013330 Bos taurus 95.27 0.00e+00 725.00
IUUC-Bol-016123 Brassica oleracea 31.60 2.00e-38 153.00
IUUC-Bra-017999 Brassica rapa 30.46 3.00e-38 152.00
IUUC-Cja-019372 Callithrix jacchus 95.31 0.00e+00 773.00
IUUC-Cfa-020668 Canis familiaris 99.05 0.00e+00 842.00
IUUC-Cpo-022092 Cavia porcellus 95.26 0.00e+00 806.00
IUUC-Cre-022929 Chlamydomonas reinhardtii 27.31 3.00e-07 49.70
IUUC-Csa-023598 Chlorocebus sabaeus 99.76 0.00e+00 849.00
IUUC-Cho-024787 Choloepus hoffmanni 92.89 0.00e+00 772.00
IUUC-Cgl-026536 Colletotrichum gloeosporioides 29.85 8.00e-40 158.00
IUUC-Dre-028795 Danio rerio 80.81 0.00e+00 723.00
IUUC-Dno-030049 Dasypus novemcinctus 93.84 0.00e+00 800.00
IUUC-Dor-030749 Dipodomys ordii 73.56 6.00e-115 407.00
IUUC-Dse-031311 Dothistroma septosporum 28.16 2.00e-34 141.00
IUUC-Ete-033027 Echinops telfairi 85.54 0.00e+00 678.00
IUUC-Eca-033723 Equus caballus 99.29 0.00e+00 842.00
IUUC-Eeu-034930 Erinaceus europaeus 84.36 0.00e+00 697.00
IUUC-Fca-035670 Felis catus 98.34 0.00e+00 838.00
IUUC-Fal-037377 Ficedula albicollis 91.94 0.00e+00 773.00
IUUC-Fox-037979 Fusarium oxysporum 28.70 6.00e-40 159.00
IUUC-Fso-038098 Fusarium solani 28.83 1.00e-40 161.00
IUUC-Gmo-038722 Gadus morhua 80.09 0.00e+00 714.00
IUUC-Gga-040836 Gallus gallus 90.52 0.00e+00 759.00
IUUC-Gac-041367 Gasterosteus aculeatus 80.57 0.00e+00 716.00
IUUC-Ggo-044534 Gorilla gorilla 100.00 0.00e+00 849.00
IUUC-Hvu-047491 Hordeum vulgare 29.70 1.00e-31 130.00
IUUC-Kpa-049356 Komagataella pastoris 29.88 1.00e-32 134.00
IUUC-Lch-050194 Latimeria chalumnae 83.41 0.00e+00 712.00
IUUC-Loc-052267 Lepisosteus oculatus 83.65 0.00e+00 744.00
IUUC-Lma-052999 Leptosphaeria maculans 27.43 2.00e-37 151.00
IUUC-Laf-053965 Loxodonta africana 92.96 0.00e+00 791.00
IUUC-Mcc-055012 Macaca mulatta 99.76 0.00e+00 849.00
IUUC-Mor-057009 Magnaporthe oryzae 28.61 2.00e-32 134.00
IUUC-Mtr-057762 Medicago truncatula 31.58 7.00e-39 154.00
IUUC-Mga-059494 Meleagris gallopavo 90.09 0.00e+00 753.00
IUUC-Mmr-061409 Microcebus murinus 99.76 0.00e+00 848.00
IUUC-Mmu-063281 Mus musculus 95.98 0.00e+00 828.00
IUUC-Mac-064776 Musa acuminata 31.37 1.00e-35 144.00
IUUC-Mpu-065900 Mustela putorius furo 99.05 0.00e+00 844.00
IUUC-Mlu-067809 Myotis lucifugus 97.16 0.00e+00 825.00
IUUC-Ncr-068681 Neurospora crassa 28.99 1.00e-29 125.00
IUUC-Nle-069953 Nomascus leucogenys 100.00 0.00e+00 849.00
IUUC-Opr-070495 Ochotona princeps 85.31 0.00e+00 715.00
IUUC-Oan-072994 Ornithorhynchus anatinus 90.28 0.00e+00 757.00
IUUC-Osa-085630 Oryza sativa 31.76 3.00e-32 134.00
IUUC-Oga-088914 Otolemur garnettii 99.50 0.00e+00 801.00
IUUC-Oar-089424 Ovis aries 90.64 0.00e+00 691.00
IUUC-Ptr-090892 Pan troglodytes 100.00 0.00e+00 849.00
IUUC-Pan-092497 Papio anubis 99.76 0.00e+00 849.00
IUUC-Pno-095080 Phaeosphaeria nodorum 29.13 1.00e-38 155.00
IUUC-Ppa-095706 Physcomitrella patens 30.11 3.00e-35 143.00
IUUC-Pab-097772 Pongo abelii 100.00 0.00e+00 849.00
IUUC-Pop-100090 Populus trichocarpa 32.43 8.00e-31 129.00
IUUC-Pca-100518 Procavia capensis 80.09 0.00e+00 644.00
IUUC-Pva-102623 Pteropus vampyrus 97.87 0.00e+00 834.00
IUUC-Pte-104289 Pyrenophora teres 28.40 2.00e-40 160.00
IUUC-Pyt-104761 Pyrenophora triticirepentis 28.40 9.00e-40 158.00
IUUC-Rno-105398 Rattus norvegicus 95.74 0.00e+00 825.00
IUUC-Smo-109364 Selaginella moellendorffii 31.56 1.00e-36 147.00
IUUC-Sit-110254 Setaria italica 30.53 2.00e-36 147.00
IUUC-Tgu-117483 Taeniopygia guttata 91.23 0.00e+00 769.00
IUUC-Tsy-119215 Tarsius syrichta 89.10 0.00e+00 745.00
IUUC-Tre-122101 Trichoderma reesei 29.98 2.00e-37 150.00
IUUC-Tvi-122616 Trichoderma virens 30.41 8.00e-41 162.00
IUUC-Tur-126305 Triticum urartu 30.30 4.00e-33 136.00
IUUC-Tme-127127 Tuber melanosporum 29.78 1.00e-40 161.00
IUUC-Tbe-128062 Tupaia belangeri 95.01 0.00e+00 798.00
IUUC-Ttr-129221 Tursiops truncatus 90.28 0.00e+00 719.00
IUUC-Vda-129798 Verticillium dahliae 29.10 2.00e-37 151.00
IUUC-Vpa-130791 Vicugna pacos 89.34 0.00e+00 740.00
IUUC-Xma-133224 Xiphophorus maculatus 81.04 0.00e+00 716.00
IUUC-Yli-134644 Yarrowia lipolytica 28.27 2.00e-29 124.00
Created Date 25-Jun-2017

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