iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000011291.2	ENSPPYT00000013112.2	ENSPPYP00000012612.2
ENSPPYG00000011291.2	ENSPPYT00000013113.2	ENSPPYP00000012613.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.90e-64	216.2	154	640

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+    ++ ++l+++++++++ +++++l+ lf+ l+ +k+k+v+p++ +++lk++ ++ +
   Q: 154  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNykppSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-N 241
           6******************************99988889999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le+++++                  + +ee +++k k+++++lF g++    + +  +++ + +e f +++l
   Q: 242  DSQQQDVSEFTHKLLDWLEDAFQM------------------KAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 310
           **********************33..................123456788999************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp+ L l++
   Q: 311  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSGKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 388
           ******.....9**************96...999998865...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 389  YMHRnreitrikreeikrlkdyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddidassppsgsipsqtlpstte 477
           ****8888888888888888888888888888888888888888888888888777777777777777777777777777777766555 PP
   S: 268  ......peekqke............................................................................ 274
                 +     e                                                                            
   Q: 478  qqgapsS-----Elpstspssvaaissrsvihkpftqsrippdlpmhpaprhiteeelsvlesclhrwrteiendtrdlqesisrihrt 561
           5555550.....05555555556666666666666666666666666666666666666677777777777777777777888888888 PP
   S: 275  ...........kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                      ++ Y+L+av+vH+G+++ GHY+ay+ +++++ W++++D  Vt++++ee ++++      ++aY+l+Y 
   Q: 562  ielmysdksmiQVPYRLHAVLVHEGQANAGHYWAYIFDHRESrWMKYNDIAVTKSSWEELVRDSFggyrnASAYCLMYI 640
           88888888888**************************966556***************99997779************6 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

HQQTFLNQLR EITGINDTQI LQQALKDSNG NLELAVAFLT AKNAKTPQQE ETTYYQTALP 60
GNDRYISVGS QADTNVIDLT GDDKDDLQRA IALSLAESNR AFRETGITDE EQAISRVLEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACCAGCAGA CGTTTTTGAA TCAACTGAGA GAAATTACGG GGATTAATGA CACCCAGATA 60
CTACAGCAAG CCTTGAAGGT ATGGCCTTTG TTTTATGATA CACAGTTTGT GGTATACGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF02809--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	96.83	0.00e+00	2038.00
IUUC-Apl-004030	Anas platyrhynchos	86.01	0.00e+00	1892.00
IUUC-Aca-004753	Anolis carolinensis	68.19	0.00e+00	1075.00
IUUC-Ani-009503	Aspergillus nidulans	33.02	7.00e-11	63.20
IUUC-Ame-010624	Astyanax mexicanus	74.49	0.00e+00	1156.00
IUUC-Bta-013166	Bos taurus	94.31	0.00e+00	1947.00
IUUC-Cel-018346	Caenorhabditis elegans	28.61	3.00e-29	124.00
IUUC-Cja-019150	Callithrix jacchus	95.95	0.00e+00	2032.00
IUUC-Cfa-020649	Canis familiaris	93.60	0.00e+00	2012.00
IUUC-Cpo-021807	Cavia porcellus	96.36	0.00e+00	2113.00
IUUC-Csa-023388	Chlorocebus sabaeus	96.04	0.00e+00	2066.00
IUUC-Cho-024343	Choloepus hoffmanni	80.21	0.00e+00	954.00
IUUC-Cin-025302	Ciona intestinalis	37.33	1.00e-95	343.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	53.19	6.00e-10	60.50
IUUC-Dre-028016	Danio rerio	77.05	0.00e+00	1167.00
IUUC-Dno-029495	Dasypus novemcinctus	91.12	0.00e+00	1995.00
IUUC-Dor-030948	Dipodomys ordii	85.59	0.00e+00	1515.00
IUUC-Fca-035876	Felis catus	94.03	0.00e+00	1977.00
IUUC-Fal-036762	Ficedula albicollis	84.26	0.00e+00	1111.00
IUUC-Gmo-039490	Gadus morhua	74.00	0.00e+00	1576.00
IUUC-Gga-040817	Gallus gallus	82.97	0.00e+00	1866.00
IUUC-Gac-042473	Gasterosteus aculeatus	74.42	0.00e+00	1611.00
IUUC-Ggo-044939	Gorilla gorilla	97.85	0.00e+00	2015.00
IUUC-Hsa-046204	Homo sapiens	96.64	0.00e+00	1977.00
IUUC-Kpa-049349	Komagataella pastoris	28.27	2.00e-10	61.60
IUUC-Lch-049572	Latimeria chalumnae	77.04	0.00e+00	1699.00
IUUC-Loc-052070	Lepisosteus oculatus	76.23	0.00e+00	1662.00
IUUC-Lma-053078	Leptosphaeria maculans	30.56	4.00e-12	67.40
IUUC-Laf-054426	Loxodonta africana	93.79	0.00e+00	1813.00
IUUC-Mcc-055858	Macaca mulatta	96.13	0.00e+00	2071.00
IUUC-Mga-059808	Meleagris gallopavo	83.30	0.00e+00	1802.00
IUUC-Mmr-060987	Microcebus murinus	94.59	0.00e+00	2011.00
IUUC-Mmu-064245	Mus musculus	90.59	0.00e+00	1938.00
IUUC-Mpu-066304	Mustela putorius furo	93.42	0.00e+00	2004.00
IUUC-Mlu-067139	Myotis lucifugus	93.10	0.00e+00	1979.00
IUUC-Nle-069075	Nomascus leucogenys	96.64	0.00e+00	1973.00
IUUC-Ont-072150	Oreochromis niloticus	71.50	0.00e+00	1615.00
IUUC-Oan-073054	Ornithorhynchus anatinus	82.88	0.00e+00	1768.00
IUUC-Ocu-074102	Oryctolagus cuniculus	91.74	0.00e+00	2006.00
IUUC-Ola-086529	Oryzias latipes	72.01	0.00e+00	1553.00
IUUC-Oga-088939	Otolemur garnettii	94.32	0.00e+00	1973.00
IUUC-Oar-090266	Ovis aries	93.51	0.00e+00	2011.00
IUUC-Ptr-090546	Pan troglodytes	96.46	0.00e+00	1973.00
IUUC-Pan-092311	Papio anubis	96.04	0.00e+00	2070.00
IUUC-Psi-093459	Pelodiscus sinensis	91.17	0.00e+00	1174.00
IUUC-Pfo-096726	Poecilia formosa	70.95	0.00e+00	1604.00
IUUC-Pca-100718	Procavia capensis	86.40	0.00e+00	1452.00
IUUC-Pva-103150	Pteropus vampyrus	95.41	0.00e+00	1523.00
IUUC-Rno-105727	Rattus norvegicus	91.43	0.00e+00	1904.00
IUUC-Sha-107051	Sarcophilus harrisii	86.66	0.00e+00	1835.00
IUUC-Sar-113097	Sorex araneus	88.53	0.00e+00	1870.00
IUUC-Ssc-115877	Sus scrofa	92.00	0.00e+00	1936.00
IUUC-Tgu-117473	Taeniopygia guttata	79.42	0.00e+00	1691.00
IUUC-Tru-118135	Takifugu rubripes	67.84	0.00e+00	1417.00
IUUC-Tsy-119471	Tarsius syrichta	93.19	0.00e+00	1881.00
IUUC-Tni-120139	Tetraodon nigroviridis	66.60	0.00e+00	1315.00
IUUC-Tbe-127549	Tupaia belangeri	91.14	0.00e+00	1887.00
IUUC-Ttr-128896	Tursiops truncatus	93.00	0.00e+00	1959.00
IUUC-Vpa-130500	Vicugna pacos	89.65	0.00e+00	1898.00
IUUC-Xtr-132896	Xenopus tropicalis	78.62	0.00e+00	1701.00
IUUC-Xma-133349	Xiphophorus maculatus	72.47	0.00e+00	1566.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence