iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046207

UUCD1 version

UUC-HoS-01199

Ensembl Protein ID

ENSP00000354201.5

UniProt Accession

Q9H832; A6N8M6; A6NC60; Q7L354; Q8TCM4; Q9H893; UBE2Z_HUMAN

Genbank Protein ID

ABR25252.1; BAB14724.1; BAB14789.1; EAW94703.1; AAH15169.2; AAH15890.1; BAB87810.1; CAG33603.1; CAD28542.1

Protein Name

Ubiquitin-conjugating enzyme E2 Z; E2 ubiquitin-conjugating enzyme Z; Uba6-specific E2 conjugating enzyme 1; Ubiquitin carrier protein Z; Ubiquitin-protein ligase Z

Genbank Nucleotide ID

EF623992; AK023917; AK024030; AC091133; BC015169; BC015890; AB025426; CR457322; AL713782

Gene Name

UBE2Z; HOYS7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000159202.17	ENST00000360943.9	ENSP00000354201.5
ENSG00000159202.17	ENST00000508468.2	ENSP00000424543.1
ENSG00000159202.17	ENST00000506498.5	ENSP00000425398.1
ENSG00000159202.17	ENST00000504684.5	ENSP00000460759.1
ENSG00000159202.17	ENST00000514948.1	ENSP00000459473.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	11806825; 19690564; 20975683

Classification

Family	E-value	Score	Start	End
E2/UBC	8.10e-39	134.2	103	243

Active Site

Position(s)	Description	Evidence
188	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk.....ifhPnvyenGkvClsilk 87
           R+k++++++ k+pp+g+++ p++  d+t++++li+Gp dtpYegg+F + +++p+dYP++PP+vk++t+     +f+Pn+y+nGkvClsil+
   Q: 103  RIKRDIMSIYKEPPPGMFVVPDTV-DMTKIHALITGPFDTPYEGGFFLFVFRCPPDYPIHPPRVKLMTTgnntvRFNPNFYRNGKVCLSILG 193
           89**********************.9*****************************************************************8 PP
   S: 88   ..eeekWspalsvesvllsiqsllae.pnpesplneeaaellkknreeykkk 136
             +  +Wspa+s++svl+siqsl++e p++++p  e+ ++    + ++y++ 
   Q: 194  twTGPAWSPAQSISSVLISIQSLMTEnPYHNEPGFEQERH--PGDSKNYNEC 243
           77899*******************655*******999864..3344446655 PP

Organism

Homo sapiens

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.

Protein Sequence
(Fasta)

MAESPTEEAA TAGAGAAGPG ASSVAGVVGV SGSGGGFGPP FLPDVWAAAA AAGGAGGPGS 60
GLAPLPGLPP SAAAHGAALL SHWDPTLSSD WDGERTAPQC LLRIKRDIMS IYKEPPPGMF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACCGTCT GGGCTGTGGA AGCGGAGGGG GTGGGGACAC TCTGGCCCGG TTCTCGGTGG 60
TGCGGGAGCG GGCGGGAGCA GCGGCCGCTC TGGTCGGCGG ACGTGCTGCC GAGTAGTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006915--P:apoptotic process
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:65264

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001560	Ailuropoda melanoleuca	95.51	2.00e-139	488.00
IUUC-Apl-003980	Anas platyrhynchos	89.83	2.00e-119	421.00
IUUC-Aca-005372	Anolis carolinensis	87.87	6.00e-128	450.00
IUUC-Acl-008373	Aspergillus clavatus	33.33	4.00e-30	125.00
IUUC-Afl-008391	Aspergillus flavus	48.60	2.00e-10	60.10
IUUC-Afu-009108	Aspergillus fumigatus	31.82	3.00e-29	123.00
IUUC-Ani-009463	Aspergillus nidulans	35.47	3.00e-42	166.00
IUUC-Ang-009532	Aspergillus niger	33.05	3.00e-20	93.20
IUUC-Ate-010525	Aspergillus terreus	32.94	3.00e-26	112.00
IUUC-Ame-011940	Astyanax mexicanus	83.46	5.00e-124	437.00
IUUC-Bta-012643	Bos taurus	99.68	7.00e-151	526.00
IUUC-Bci-013596	Botrytis cinerea	37.05	7.00e-35	141.00
IUUC-Cja-018722	Callithrix jacchus	98.53	2.00e-148	518.00
IUUC-Cfa-020605	Canis familiaris	99.20	3.00e-137	480.00
IUUC-Cpo-021673	Cavia porcellus	89.44	5.00e-132	463.00
IUUC-Csa-024068	Chlorocebus sabaeus	100.00	2.00e-151	528.00
IUUC-Cho-024675	Choloepus hoffmanni	100.00	5.00e-82	297.00
IUUC-Cgl-026412	Colletotrichum gloeosporioides	37.31	1.00e-34	141.00
IUUC-Dre-027988	Danio rerio	81.92	3.00e-124	438.00
IUUC-Dno-029140	Dasypus novemcinctus	92.04	7.00e-141	493.00
IUUC-Dor-030106	Dipodomys ordii	86.69	6.00e-112	396.00
IUUC-Dse-031321	Dothistroma septosporum	46.89	5.00e-38	152.00
IUUC-Ete-032239	Echinops telfairi	92.80	9.00e-58	216.00
IUUC-Eca-034348	Equus caballus	98.82	5.00e-138	483.00
IUUC-Eeu-034803	Erinaceus europaeus	96.88	6.00e-117	412.00
IUUC-Fca-036527	Felis catus	91.90	1.00e-142	499.00
IUUC-Fal-036839	Ficedula albicollis	93.55	8.00e-60	222.00
IUUC-Fox-037961	Fusarium oxysporum	37.08	6.00e-33	135.00
IUUC-Fso-038352	Fusarium solani	34.47	2.00e-29	123.00
IUUC-Gmo-038800	Gadus morhua	84.00	2.00e-121	429.00
IUUC-Ggr-040018	Gaeumannomyces graminis	37.92	4.00e-31	129.00
IUUC-Gga-041237	Gallus gallus	89.11	4.00e-129	454.00
IUUC-Gac-041848	Gasterosteus aculeatus	85.43	4.00e-121	427.00
IUUC-Ggo-045631	Gorilla gorilla	78.29	3.00e-111	394.00
IUUC-Itr-048609	Ictidomys tridecemlineatus	98.82	5.00e-138	483.00
IUUC-Lch-050278	Latimeria chalumnae	89.67	2.00e-124	438.00
IUUC-Loc-051768	Lepisosteus oculatus	87.14	2.00e-70	258.00
IUUC-Lma-053044	Leptosphaeria maculans	38.15	7.00e-41	161.00
IUUC-Laf-053726	Loxodonta africana	98.04	6.00e-136	476.00
IUUC-Meu-056221	Macropus eugenii	78.73	3.00e-90	324.00
IUUC-Mor-057074	Magnaporthe oryzae	38.95	7.00e-32	131.00
IUUC-Mpo-057495	Magnaporthe poae	37.64	2.00e-31	130.00
IUUC-Mga-060059	Meleagris gallopavo	90.99	2.00e-118	418.00
IUUC-Mmr-061455	Microcebus murinus	98.03	2.00e-138	484.00
IUUC-Mdo-062002	Monodelphis domestica	95.50	7.00e-120	422.00
IUUC-Mmu-063224	Mus musculus	100.00	2.00e-151	528.00
IUUC-Mpu-066230	Mustela putorius furo	98.05	1.00e-138	485.00
IUUC-Mlu-067587	Myotis lucifugus	91.35	9.00e-141	493.00
IUUC-Nfi-068281	Neosartorya fischeri	34.41	4.00e-32	132.00
IUUC-Ncr-068852	Neurospora crassa	36.90	2.00e-30	126.00
IUUC-Nle-069355	Nomascus leucogenys	86.05	4.00e-116	410.00
IUUC-Opr-070408	Ochotona princeps	83.40	1.00e-99	356.00
IUUC-Ont-071793	Oreochromis niloticus	85.43	7.00e-123	433.00
IUUC-Oan-073328	Ornithorhynchus anatinus	96.88	1.00e-84	305.00
IUUC-Ocu-073819	Oryctolagus cuniculus	100.00	4.00e-152	530.00
IUUC-Ola-087432	Oryzias latipes	86.34	4.00e-110	390.00
IUUC-Oga-087941	Otolemur garnettii	100.00	2.00e-151	528.00
IUUC-Oar-089782	Ovis aries	92.81	1.00e-140	493.00
IUUC-Ptr-091361	Pan troglodytes	99.37	8.00e-155	539.00
IUUC-Pan-092426	Papio anubis	100.00	1.00e-151	529.00
IUUC-Pma-094305	Petromyzon marinus	86.81	4.00e-88	317.00
IUUC-Pno-094902	Phaeosphaeria nodorum	31.84	8.00e-22	98.20
IUUC-Pfo-097059	Poecilia formosa	84.21	1.00e-127	449.00
IUUC-Pab-097711	Pongo abelii	87.40	1.00e-110	392.00
IUUC-Pca-100473	Procavia capensis	100.00	2.00e-136	478.00
IUUC-Pva-103012	Pteropus vampyrus	100.00	2.00e-151	528.00
IUUC-Pte-104107	Pyrenophora teres	38.89	1.00e-41	164.00
IUUC-Pyt-104452	Pyrenophora triticirepentis	38.52	2.00e-41	163.00
IUUC-Rno-105444	Rattus norvegicus	100.00	2.00e-151	528.00
IUUC-Sha-107291	Sarcophilus harrisii	95.50	7.00e-120	422.00
IUUC-Sar-113102	Sorex araneus	77.37	4.00e-88	318.00
IUUC-Ssc-115575	Sus scrofa	100.00	5.00e-153	533.00
IUUC-Tru-117883	Takifugu rubripes	84.13	2.00e-122	432.00
IUUC-Tsy-119638	Tarsius syrichta	72.58	7.00e-95	340.00
IUUC-Tni-120523	Tetraodon nigroviridis	84.68	3.00e-121	428.00
IUUC-Tre-121946	Trichoderma reesei	34.34	9.00e-34	137.00
IUUC-Tvi-122513	Trichoderma virens	35.69	4.00e-36	145.00
IUUC-Tme-126888	Tuber melanosporum	37.14	4.00e-33	135.00
IUUC-Tbe-127392	Tupaia belangeri	63.35	1.00e-53	202.00
IUUC-Ttr-128772	Tursiops truncatus	100.00	2.00e-136	478.00
IUUC-Vda-129728	Verticillium dahliae	35.59	3.00e-33	135.00
IUUC-Vpa-130763	Vicugna pacos	79.71	3.00e-83	300.00
IUUC-Xtr-132764	Xenopus tropicalis	80.16	6.00e-110	390.00
IUUC-Xma-134051	Xiphophorus maculatus	85.43	1.00e-122	432.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence