iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-067167

Ensembl Protein ID

ENSMLUP00000010063.2

UniProt Accession

G1PHB8; G1PHB8_MYOLU

Genbank Protein ID

ENSMLUP00000010063

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAPE02007300

Gene Name

FRK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000011037.2	ENSMLUT00000011043.2	ENSMLUP00000010063.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-10	41.1	47	108

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk.......elegkrGlfPenFvek 61
           ++ +l+dy+a ++++L++++Gd+++v+  ++  egW+ +           ++ +G +P+n+v++
   Q: 47   YFVALFDYQARTEEDLSFHAGDKLQVL--DTSHEGWWFARLlerrgasSGQQLEGYIPSNYVAE 108
           7899***********************..89999***99889999977777789*******975 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MGNICRRLWG YLKPCLPCFF RETDKQVAPE NTESPCPAEA PWPQGSYFVA LFDYQARTEE 60
DLSFHAGDKL QVLDTSHEGW WFARLLERRG ASSGQQLEGY IPSNYVAEDR SLQAEPWFFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCAACA TCTGCCGGAG GCTCTGGGGG TACTTGAAGC CCTGTCTCCC CTGCTTCTTC 60
CGGGAGACAG ACAAACAGGT GGCGCCTGAG AACACAGAGA GCCCCTGCCC CGCTGAGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003394	Anas platyrhynchos	68.29	0.00e+00	704.00
IUUC-Aca-004553	Anolis carolinensis	67.19	0.00e+00	699.00
IUUC-Cja-019885	Callithrix jacchus	82.57	0.00e+00	860.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	31.06	3.00e-20	92.80
IUUC-Dre-028274	Danio rerio	58.75	2.00e-170	592.00
IUUC-Dno-029689	Dasypus novemcinctus	80.16	0.00e+00	843.00
IUUC-Eeu-034770	Erinaceus europaeus	67.71	2.00e-175	608.00
IUUC-Fal-036892	Ficedula albicollis	74.72	0.00e+00	685.00
IUUC-Gga-041072	Gallus gallus	67.17	0.00e+00	696.00
IUUC-Loc-052913	Lepisosteus oculatus	60.71	2.00e-171	595.00
IUUC-Mga-059456	Meleagris gallopavo	67.37	0.00e+00	686.00
IUUC-Mmr-061480	Microcebus murinus	80.32	0.00e+00	810.00
IUUC-Mac-065247	Musa acuminata	28.57	9.00e-23	102.00
IUUC-Nle-069786	Nomascus leucogenys	81.19	0.00e+00	850.00
IUUC-Ont-072417	Oreochromis niloticus	64.47	5.00e-175	607.00
IUUC-Osa-085612	Oryza sativa	28.95	6.00e-21	95.10
IUUC-Ola-086419	Oryzias latipes	59.80	9.00e-172	596.00
IUUC-Pan-092732	Papio anubis	81.19	0.00e+00	846.00
IUUC-Psi-093899	Pelodiscus sinensis	69.53	0.00e+00	720.00
IUUC-Pma-094230	Petromyzon marinus	59.57	2.00e-158	552.00
IUUC-Pfo-096035	Poecilia formosa	60.04	4.00e-167	580.00
IUUC-Pva-103122	Pteropus vampyrus	61.63	3.00e-172	598.00
IUUC-Rno-105269	Rattus norvegicus	82.02	0.00e+00	851.00
IUUC-Tgu-116491	Taeniopygia guttata	74.66	0.00e+00	692.00
IUUC-Tru-117795	Takifugu rubripes	57.72	6.00e-156	544.00
IUUC-Tni-120512	Tetraodon nigroviridis	62.39	5.00e-173	600.00
IUUC-Ttr-128817	Tursiops truncatus	82.27	0.00e+00	846.00
IUUC-Vpa-130389	Vicugna pacos	76.19	0.00e+00	773.00
IUUC-Xtr-132360	Xenopus tropicalis	58.11	5.00e-177	613.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence