iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093899

Ensembl Protein ID

ENSPSIP00000005003.1

UniProt Accession

K7FAE3; K7FAE3_PELSI

Genbank Protein ID

ENSPSIP00000005003

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AGCU01088102

Gene Name

FRK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000004668.1	ENSPSIT00000005032.1	ENSPSIP00000005003.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.10e-11	43.1	51	117

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk........elegkrGlfPenFvekle 63
            + + +l+dy+a + d+L+++ Gd+++v+  ++  egW++++           ++ +G +P+n+v+ ++
   Q: 51   RHNFVALFDYQARTIDDLSFRTGDKLEVL--DTSPEGWWYATLlldsgstqPGQTLSGYIPANYVAPVQ 117
           67889************************..9999******9999999977777889********9987 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MGNFCRKHCI CMQRCAPWLF QESDDGDNTA QAGVDAGIPL PPPRDQKPTN RHNFVALFDY 60
QARTIDDLSF RTGDKLEVLD TSPEGWWYAT LLLDSGSTQP GQTLSGYIPA NYVAPVQSIE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGAACT TTTGCCGGAA GCATTGCATT TGTATGCAGA GGTGTGCCCC TTGGCTCTTC 60
CAAGAGAGTG ATGATGGAGG AGAGGGGGAG AAATATAAGA CAGGCCATGT TAATCGTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	29.89	8.00e-24	105.00
IUUC-Apl-003394	Anas platyrhynchos	70.97	0.00e+00	741.00
IUUC-Aca-004553	Anolis carolinensis	70.70	0.00e+00	776.00
IUUC-Cja-019885	Callithrix jacchus	71.93	0.00e+00	765.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	27.34	1.00e-21	97.10
IUUC-Cin-025605	Ciona intestinalis	55.13	1.00e-151	529.00
IUUC-Dre-028274	Danio rerio	64.42	5.00e-178	617.00
IUUC-Dno-029689	Dasypus novemcinctus	72.55	0.00e+00	756.00
IUUC-Dme-031976	Drosophila melanogaster	57.04	1.00e-170	592.00
IUUC-Eeu-034770	Erinaceus europaeus	58.76	8.00e-147	513.00
IUUC-Fal-036892	Ficedula albicollis	70.11	0.00e+00	746.00
IUUC-Gga-041072	Gallus gallus	73.60	0.00e+00	767.00
IUUC-Hvu-047855	Hordeum vulgare	29.12	3.00e-23	103.00
IUUC-Loc-052913	Lepisosteus oculatus	63.09	1.00e-178	619.00
IUUC-Mga-059456	Meleagris gallopavo	73.60	0.00e+00	757.00
IUUC-Mmr-061480	Microcebus murinus	70.48	0.00e+00	723.00
IUUC-Mac-065247	Musa acuminata	30.86	4.00e-23	103.00
IUUC-Mlu-067167	Myotis lucifugus	69.53	0.00e+00	720.00
IUUC-Nle-069786	Nomascus leucogenys	71.15	0.00e+00	761.00
IUUC-Ont-072417	Oreochromis niloticus	64.49	4.00e-178	617.00
IUUC-Ola-086419	Oryzias latipes	61.26	1.00e-177	615.00
IUUC-Pan-092732	Papio anubis	70.76	0.00e+00	753.00
IUUC-Pma-094230	Petromyzon marinus	62.47	4.00e-174	603.00
IUUC-Pfo-096035	Poecilia formosa	61.05	8.00e-171	593.00
IUUC-Pva-103122	Pteropus vampyrus	52.24	1.00e-143	503.00
IUUC-Rno-105269	Rattus norvegicus	70.90	0.00e+00	737.00
IUUC-Tgu-116491	Taeniopygia guttata	76.03	0.00e+00	729.00
IUUC-Tru-117795	Takifugu rubripes	60.13	1.00e-162	566.00
IUUC-Tni-120512	Tetraodon nigroviridis	66.81	0.00e+00	637.00
IUUC-Tae-123192	Triticum aestivum	29.89	5.00e-24	106.00
IUUC-Ttr-128817	Tursiops truncatus	70.70	0.00e+00	740.00
IUUC-Vpa-130389	Vicugna pacos	67.79	0.00e+00	677.00
IUUC-Xtr-132360	Xenopus tropicalis	61.39	0.00e+00	675.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence