iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000154016.13	ENST00000284154.9	ENSP00000284154.5
ENSG00000154016.13	ENST00000573099.5	ENSP00000459833.1
ENSG00000154016.13	ENST00000583020.1	ENSP00000464328.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.50e-28	100.2	4	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            +ly+++a+++deL ++kGd+++++ + e d++W k+  el+g +G++P+n+++
   Q: 4    VALYSFQATESDELAFNKGDTLKIL-NMEDDQNWYKA--ELRGVEGFIPKNYIR 54
           58***********************.99*******99..9************97 PP

Organism

Homo sapiens

Functional Description
(View)

Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB.

Protein Sequence
(Fasta)

MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW 60
YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN YGDQVQHFKV LREASGKYFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCTTCTGAG CTGGTCTTTG ATGGATGAAT AGGAGTCTCC TGGGAGCAGA AAGAGGAGAA 60
CACCAGGCAG AGGAACCACG TGTGCAAAAG TCTGGGGTTG AAATGAGAGT TTGGTGTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0007267--P:cell-cell signaling
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0007265--P:Ras protein signal transduction
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

hsa:10750

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001277	Ailuropoda melanoleuca	95.39	3.00e-122	430.00
IUUC-Apl-003499	Anas platyrhynchos	64.38	1.00e-75	275.00
IUUC-Aca-004922	Anolis carolinensis	66.82	3.00e-86	311.00
IUUC-Ago-007965	Ashbya gossypii	48.15	1.00e-12	67.00
IUUC-Bta-012909	Bos taurus	91.24	2.00e-117	414.00
IUUC-Cja-018796	Callithrix jacchus	98.16	1.00e-126	445.00
IUUC-Cfa-021023	Canis familiaris	93.09	1.00e-119	422.00
IUUC-Cpo-021502	Cavia porcellus	96.31	2.00e-124	437.00
IUUC-Csa-024099	Chlorocebus sabaeus	98.62	1.00e-126	444.00
IUUC-Dno-029057	Dasypus novemcinctus	89.22	2.00e-85	308.00
IUUC-Eca-033722	Equus caballus	80.93	1.00e-101	361.00
IUUC-Eeu-035125	Erinaceus europaeus	79.49	2.00e-44	170.00
IUUC-Fca-036087	Felis catus	95.39	2.00e-122	431.00
IUUC-Fal-037633	Ficedula albicollis	77.21	3.00e-96	344.00
IUUC-Gga-041204	Gallus gallus	77.42	4.00e-98	350.00
IUUC-Ggo-044579	Gorilla gorilla	100.00	9.00e-129	452.00
IUUC-Loc-052457	Lepisosteus oculatus	61.57	8.00e-76	276.00
IUUC-Laf-053794	Loxodonta africana	94.93	5.00e-122	429.00
IUUC-Mcc-055527	Macaca mulatta	99.08	1.00e-127	448.00
IUUC-Meu-056608	Macropus eugenii	82.72	2.00e-86	310.00
IUUC-Mmr-060743	Microcebus murinus	85.25	2.00e-105	374.00
IUUC-Mdo-063025	Monodelphis domestica	86.18	3.00e-112	397.00
IUUC-Mmu-064395	Mus musculus	92.17	3.00e-119	420.00
IUUC-Mpu-066088	Mustela putorius furo	93.55	4.00e-120	424.00
IUUC-Mlu-067003	Myotis lucifugus	93.55	2.00e-119	421.00
IUUC-Opr-071051	Ochotona princeps	69.59	4.00e-82	297.00
IUUC-Ont-071576	Oreochromis niloticus	62.04	5.00e-79	286.00
IUUC-Oan-073107	Ornithorhynchus anatinus	68.12	1.00e-84	305.00
IUUC-Ocu-074963	Oryctolagus cuniculus	93.12	5.00e-110	390.00
IUUC-Ola-086725	Oryzias latipes	58.48	3.00e-72	264.00
IUUC-Oga-088158	Otolemur garnettii	94.01	2.00e-121	427.00
IUUC-Oar-090223	Ovis aries	88.48	6.00e-113	400.00
IUUC-Pan-092422	Papio anubis	99.54	3.00e-128	450.00
IUUC-Psi-093655	Pelodiscus sinensis	80.18	5.00e-104	369.00
IUUC-Pca-100573	Procavia capensis	93.37	3.00e-99	353.00
IUUC-Pva-102471	Pteropus vampyrus	96.34	8.00e-109	385.00
IUUC-Rno-105932	Rattus norvegicus	90.78	6.00e-118	416.00
IUUC-Sha-107209	Sarcophilus harrisii	84.33	2.00e-101	361.00
IUUC-Tru-118065	Takifugu rubripes	59.72	1.00e-74	272.00
IUUC-Tni-120563	Tetraodon nigroviridis	56.48	1.00e-68	252.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence