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Tag Content
UUCD2 ID IUUC-Tgu-117079
UUCD1 version UUC-TaG-00617
Ensembl Protein ID ENSTGUP00000012107.1
UniProt Accession H0ZND1; H0ZND1_TAEGU
Genbank Protein ID ENSTGUP00000012107
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID ABQF01005629
Gene Name WWP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSTGUG00000011745.1 ENSTGUT00000012241.1 ENSTGUP00000012107.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 7.80e-135 449.4 592 924
Active Site
Position(s) Description Evidence
893 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 592  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 679
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee++l++ f+v+ e+lg+++++eLk+gG+ni Vt+eNkeeY+ l++e
   Q: 680  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECNLEMYFCVDMELLGKVTSHELKSGGSNILVTEENKEEYIGLMAE 765
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l +F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 766  WRFSRGVREQTKAFLDGFNEVVPLQWLHYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 853
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 854  TGTCRLPLGGFAELMgsngPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 924
           *********************************************************************96 PP
   
Organism Taeniopygia guttata
Protein Sequence
(Fasta)
MATASPRSDT SHNCNGRLQM QVTVSSAKLK RKKNWFGTTF YTELTADGEI KKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTLKA DALLGRATVD LRQALEVHNR KLEKVKEQLK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Tgu-117079|E3,HECT|Taeniopygia guttata
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCCACAG CCTCACCAAG ATCTGATACA AGTCACAACT GTAATGGAAG ATTACAGATG 60
CAAGTAACAG GCAAGTAGTG ATTTTTATCA TAGAGATTTT TATAGGAAAA CATATGTATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Tgu-117079|E3,HECT|Taeniopygia guttata
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
KEGG tgu:100219204
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001213 Ailuropoda melanoleuca 83.41 0.00e+00 1529.00
IUUC-Apl-003310 Anas platyrhynchos 95.03 0.00e+00 1716.00
IUUC-Aca-005388 Anolis carolinensis 84.26 0.00e+00 1527.00
IUUC-Ame-010992 Astyanax mexicanus 93.60 0.00e+00 866.00
IUUC-Bta-012857 Bos taurus 82.96 0.00e+00 1509.00
IUUC-Cel-018299 Caenorhabditis elegans 68.05 0.00e+00 849.00
IUUC-Cja-019448 Callithrix jacchus 83.30 0.00e+00 1540.00
IUUC-Cfa-020728 Canis familiaris 83.73 0.00e+00 1517.00
IUUC-Cpo-021635 Cavia porcellus 80.02 0.00e+00 1494.00
IUUC-Csa-023805 Chlorocebus sabaeus 85.82 0.00e+00 1187.00
IUUC-Cho-024943 Choloepus hoffmanni 72.58 0.00e+00 1002.00
IUUC-Cin-025212 Ciona intestinalis 74.09 0.00e+00 915.00
IUUC-Csv-026256 Ciona savignyi 73.18 0.00e+00 910.00
IUUC-Dre-028245 Danio rerio 73.48 0.00e+00 1246.00
IUUC-Dno-029618 Dasypus novemcinctus 82.56 0.00e+00 1514.00
IUUC-Dme-032041 Drosophila melanogaster 70.56 0.00e+00 899.00
IUUC-Ete-032779 Echinops telfairi 91.73 0.00e+00 1081.00
IUUC-Eca-033313 Equus caballus 82.11 0.00e+00 1498.00
IUUC-Eeu-035259 Erinaceus europaeus 74.87 0.00e+00 1344.00
IUUC-Fca-035420 Felis catus 82.22 0.00e+00 1513.00
IUUC-Fal-037335 Ficedula albicollis 98.49 0.00e+00 1788.00
IUUC-Gmo-039172 Gadus morhua 88.01 0.00e+00 1070.00
IUUC-Gga-040246 Gallus gallus 93.62 0.00e+00 1694.00
IUUC-Gac-042211 Gasterosteus aculeatus 92.48 0.00e+00 1186.00
IUUC-Ggo-045001 Gorilla gorilla 82.76 0.00e+00 1355.00
IUUC-Hsa-046544 Homo sapiens 82.88 0.00e+00 1538.00
IUUC-Itr-048860 Ictidomys tridecemlineatus 82.38 0.00e+00 1486.00
IUUC-Lch-050398 Latimeria chalumnae 79.16 0.00e+00 1422.00
IUUC-Loc-052116 Lepisosteus oculatus 76.96 0.00e+00 1410.00
IUUC-Laf-053551 Loxodonta africana 83.01 0.00e+00 1501.00
IUUC-Mga-059986 Meleagris gallopavo 93.41 0.00e+00 1712.00
IUUC-Mmr-060945 Microcebus murinus 79.98 0.00e+00 1462.00
IUUC-Mdo-063024 Monodelphis domestica 81.31 0.00e+00 1461.00
IUUC-Mmu-063202 Mus musculus 80.50 0.00e+00 1456.00
IUUC-Mpu-065773 Mustela putorius furo 83.66 0.00e+00 1517.00
IUUC-Mlu-067373 Myotis lucifugus 93.57 0.00e+00 633.00
IUUC-Nle-069188 Nomascus leucogenys 83.21 0.00e+00 1545.00
IUUC-Opr-070965 Ochotona princeps 80.13 0.00e+00 1456.00
IUUC-Ont-072226 Oreochromis niloticus 92.83 0.00e+00 1191.00
IUUC-Oan-073497 Ornithorhynchus anatinus 85.22 0.00e+00 1547.00
IUUC-Ocu-073891 Oryctolagus cuniculus 79.20 0.00e+00 1422.00
IUUC-Ola-087438 Oryzias latipes 89.66 0.00e+00 1182.00
IUUC-Oga-087922 Otolemur garnettii 82.47 0.00e+00 1512.00
IUUC-Oar-089317 Ovis aries 82.88 0.00e+00 1494.00
IUUC-Ptr-090484 Pan troglodytes 82.78 0.00e+00 1538.00
IUUC-Pan-092117 Papio anubis 82.78 0.00e+00 1534.00
IUUC-Psi-093338 Pelodiscus sinensis 89.31 0.00e+00 1649.00
IUUC-Pma-094279 Petromyzon marinus 74.26 0.00e+00 840.00
IUUC-Pfo-096171 Poecilia formosa 92.66 0.00e+00 1186.00
IUUC-Pab-098654 Pongo abelii 83.50 0.00e+00 1150.00
IUUC-Pva-102811 Pteropus vampyrus 73.58 0.00e+00 1310.00
IUUC-Rno-106125 Rattus norvegicus 80.41 0.00e+00 1474.00
IUUC-Sha-107243 Sarcophilus harrisii 83.14 0.00e+00 1528.00
IUUC-Ssc-115368 Sus scrofa 81.34 0.00e+00 1503.00
IUUC-Tru-118062 Takifugu rubripes 73.06 0.00e+00 1363.00
IUUC-Tsy-119507 Tarsius syrichta 78.04 0.00e+00 1414.00
IUUC-Tni-120151 Tetraodon nigroviridis 70.94 0.00e+00 1335.00
IUUC-Ttr-129260 Tursiops truncatus 72.63 0.00e+00 1265.00
IUUC-Xtr-132877 Xenopus tropicalis 71.73 0.00e+00 1251.00
Created Date 25-Jun-2017

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