iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074823

UUCD1 version

UUC-OrC-01044

Ensembl Protein ID

ENSOCUP00000005290.3

UniProt Accession

G1SQC2; G1SQC2_RABIT

Protein Name

Uncharacterized protein

Gene Name

USP36

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000006102.3	ENSOCUT00000006107.3	ENSOCUP00000005290.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-74	251.4	204	549

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           Gl+NlgNtC++NS++QcL+ +p+l+++ll+ ++ ++++     +   ++l+ +q+ + +   ++ +a++p ++++ l+k+a++f+  +q
   Q: 204  GLHNLGNTCFLNSTVQCLTYTPPLANYLLSqEHARNCH-----QGGFCMLCVMQNHIIQAFANSGNAIKPVSFIRDLRKIARHFRFGNQ 287
           9*****************************33333443.....456799999999999999**************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da+Efl++ +d++++++                  l+  a+ + +++ ++l++++F+g l+s++kc  c++vs +++p ld+ l++++
   Q: 288  EDAHEFLRYTIDAMQKAC------------------LNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSLCKSVSDTYDPYLDIALEIRQ 358
           ******************..................344556788999***************************************** PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekck...............................................kkqeaekk 220
                  ++  +Le f+k++ l gen+y c k +                                               kk+ a+k+
   Q: 359  AA-----NIVRALELFVKPDVLSGENAYLCAKSCsllpawahwslltltrhvhvllvlwlhcshwsscwcccvflrlrwckKKVPASKR 442
           **.....9***********************9998***********999999999999999999999999999999999999999**** PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWll 308
           +++++ ++vL+l LkRf    ++ s  ki+k v +p+ L+++p++++++ +   +++Y L+av+vHsG s++ GHY++yvk ++g+W++
   Q: 443  FSIHRTSNVLTLSLKRF----ANFSGGKITKDVGYPEFLNIRPYMSQSSGE---PVTYGLYAVLVHSGySCHAGHYYCYVKASNGQWYQ 524
           *****************....668899********************5544...9********************************** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYk 336
           ++Ds V++++ + vl+   ++aYvlfY 
   Q: 525  MNDSLVHSSNVKVVLN---QQAYVLFYL 549
           ****************...********6 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MFKGPDKDIE FIYTAPSSAV CGVSLDVGGK KEYLIAGKAE GDGRMHITLC DFIVPWDSLS 60
STQKKSLNHR YQMGCECKCC AMPIVEKLKE ALKPGRRDAA DDGDLGKLLA SSAKRVLLQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGATCAGGGC CAAAGCGGTC AGCGAGAAGG AGGTGGACTC TGGGAACGAC ATCTACGGCA 60
ACCCCATCAA GAGGATCCAG TATGAGATCA AGCAGATCAA GGTGAGCGCC GTCCCCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-1185--Reference proteome
KW-0964--Secreted

Interpro

IPR001134--Netrin_domain
IPR001394--Peptidase_C19_UCH
IPR001820--TIMP
IPR008993--TIMP-like_OB-fold
IPR027465--TIMP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50189--NTR
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00965--TIMP
PF00443--UCH

SMART

SM00206--NTR

Gene Ontology

GO:0005576--C:extracellular region
GO:0016607--C:nuclear speck
GO:0005730--C:nucleolus
GO:0008191--F:metalloendopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:1903146--P:regulation of mitophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002092	Ailuropoda melanoleuca	61.62	0.00e+00	1133.00
IUUC-Aca-005360	Anolis carolinensis	56.37	0.00e+00	832.00
IUUC-Bta-013047	Bos taurus	61.47	0.00e+00	1102.00
IUUC-Cja-019203	Callithrix jacchus	64.18	0.00e+00	1135.00
IUUC-Cfa-020586	Canis familiaris	63.88	0.00e+00	1193.00
IUUC-Cpo-021804	Cavia porcellus	61.97	0.00e+00	1125.00
IUUC-Csa-023137	Chlorocebus sabaeus	66.38	0.00e+00	1219.00
IUUC-Cin-025230	Ciona intestinalis	46.42	4.00e-92	331.00
IUUC-Dre-028587	Danio rerio	64.91	0.00e+00	754.00
IUUC-Dno-029149	Dasypus novemcinctus	61.72	0.00e+00	1134.00
IUUC-Dor-030836	Dipodomys ordii	66.29	3.00e-152	533.00
IUUC-Dme-032119	Drosophila melanogaster	30.04	5.00e-63	236.00
IUUC-Ete-032567	Echinops telfairi	61.51	0.00e+00	787.00
IUUC-Eca-033600	Equus caballus	63.78	0.00e+00	1177.00
IUUC-Fal-036852	Ficedula albicollis	62.81	3.00e-148	519.00
IUUC-Gmo-039033	Gadus morhua	65.21	0.00e+00	746.00
IUUC-Gga-040664	Gallus gallus	68.67	0.00e+00	721.00
IUUC-Gac-042176	Gasterosteus aculeatus	63.11	0.00e+00	752.00
IUUC-Ggo-045437	Gorilla gorilla	65.96	0.00e+00	1175.00
IUUC-Hsa-046863	Homo sapiens	65.87	0.00e+00	1192.00
IUUC-Itr-048655	Ictidomys tridecemlineatus	69.18	0.00e+00	1013.00
IUUC-Loc-052796	Lepisosteus oculatus	63.58	0.00e+00	725.00
IUUC-Laf-054243	Loxodonta africana	60.85	0.00e+00	1160.00
IUUC-Mcc-055762	Macaca mulatta	66.04	0.00e+00	1195.00
IUUC-Meu-056697	Macropus eugenii	57.39	0.00e+00	1093.00
IUUC-Mga-059359	Meleagris gallopavo	64.67	2.00e-148	519.00
IUUC-Mmr-060966	Microcebus murinus	63.29	0.00e+00	1158.00
IUUC-Mdo-062733	Monodelphis domestica	63.66	0.00e+00	949.00
IUUC-Mmu-064331	Mus musculus	63.16	0.00e+00	1161.00
IUUC-Mpu-065759	Mustela putorius furo	61.66	0.00e+00	1096.00
IUUC-Mlu-067371	Myotis lucifugus	69.54	0.00e+00	920.00
IUUC-Nle-070087	Nomascus leucogenys	65.53	0.00e+00	1161.00
IUUC-Opr-070729	Ochotona princeps	87.46	5.00e-162	565.00
IUUC-Ont-071346	Oreochromis niloticus	68.89	0.00e+00	752.00
IUUC-Oan-072931	Ornithorhynchus anatinus	64.32	0.00e+00	822.00
IUUC-Ola-087255	Oryzias latipes	63.79	0.00e+00	751.00
IUUC-Oga-088818	Otolemur garnettii	64.79	0.00e+00	966.00
IUUC-Oar-089410	Ovis aries	59.11	0.00e+00	1072.00
IUUC-Ptr-090680	Pan troglodytes	65.41	0.00e+00	1001.00
IUUC-Pan-092482	Papio anubis	65.87	0.00e+00	1202.00
IUUC-Pma-094591	Petromyzon marinus	57.71	6.00e-51	193.00
IUUC-Pfo-096807	Poecilia formosa	63.97	0.00e+00	761.00
IUUC-Pab-098724	Pongo abelii	65.90	0.00e+00	1207.00
IUUC-Pca-100117	Procavia capensis	83.73	8.00e-129	454.00
IUUC-Pva-102883	Pteropus vampyrus	81.88	6.00e-130	458.00
IUUC-Rno-105340	Rattus norvegicus	63.71	0.00e+00	974.00
IUUC-Sha-107019	Sarcophilus harrisii	57.79	0.00e+00	1096.00
IUUC-Sja-107805	Schizosaccharomyces japonicus	36.45	3.00e-71	261.00
IUUC-Ssc-116022	Sus scrofa	74.10	0.00e+00	812.00
IUUC-Tgu-116976	Taeniopygia guttata	64.33	5.00e-153	533.00
IUUC-Tru-118391	Takifugu rubripes	58.63	0.00e+00	770.00
IUUC-Tsy-119253	Tarsius syrichta	53.04	0.00e+00	716.00
IUUC-Tni-120064	Tetraodon nigroviridis	70.37	0.00e+00	758.00
IUUC-Tbe-127377	Tupaia belangeri	53.39	0.00e+00	684.00
IUUC-Ttr-129259	Tursiops truncatus	56.92	0.00e+00	932.00
IUUC-Vpa-130568	Vicugna pacos	69.23	6.00e-45	176.00
IUUC-Xtr-132944	Xenopus tropicalis	68.44	0.00e+00	640.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence