iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005278

UUCD1 version

UUC-AnC-00994

Ensembl Protein ID

ENSACAP00000002939.2

UniProt Accession

G1KBF8; G1KBF8_ANOCA

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000002993.2	ENSACAT00000003015.2	ENSACAP00000002939.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.20e-96	322.0	260	664

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGlkNlgNtCYmNS+LQ+Ls+++++re++l+           +++    +                                       
   Q: 260  TGLKNLGNTCYMNSILQVLSHLQKFRECFLTldlceteeLLAKTV----Ngksrmsgklvsglgptesgrndqlgsygrqslpaglngg 344
           7******************************88875554344444....25555999999***************************** PP
   S: 43   ...............kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpke 116
                          ++++ +l+++l++lf+ +w++k+ +vsp ++l++++++ + f+gy+q DaqEfl+ lld++++el         
   Q: 345  ssisksleltqpkepSSKHISLCHELHTLFRVMWSGKWASVSPFAMLHSVWSLIPAFRGYDQ-DAQEFLCELLDKVQQEL--------- 423
           *******9999999888999***************************************985.*****************......... PP
   S: 117  eeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesft 195
           e+e+++++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft
   Q: 424  ESEGTKRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCITCNYKSNTVEPFWDLSLEFPERYHSINKgivpvnqtecMLTEMLAKFT 512
           6788899999999************************************************9998877799*******9********** PP
   S: 196  keeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqk 273
           ++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ ++ 
   Q: 513  ETEALEGRI-YACDQCNSKRRksspkplilseAKKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVLFDQVLNMEPYCCRDTLSSL 599
           ******965.*********999*********************************997.8889********************887765 PP
   S: 274  e..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           +  +  Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 600  DkeTFVYDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 664
           433899*************************9999********************...********98 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWHCMDCN TTESIWACLK CSHVACGRYI EDHALKHFEE 60
TRHPLAMEVN DFYVFCYLCE DYVLNDNPEG DLKLLRSSLS AIKSQKHDPS ARSGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT TGGGCGGCTA CGACTTGCCC AAGACCACTC TATTCTGAAC 60
CCCCAGAAGT GGCACTGCAT GGACTGCAAC ACCACAGAAT CCATTTGGGC TTGCCTGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003658	Anas platyrhynchos	92.11	0.00e+00	1277.00
IUUC-Bta-012911	Bos taurus	78.37	0.00e+00	1018.00
IUUC-Cja-019171	Callithrix jacchus	79.17	0.00e+00	1054.00
IUUC-Cfa-020408	Canis familiaris	78.76	0.00e+00	1036.00
IUUC-Cpo-022233	Cavia porcellus	72.69	0.00e+00	962.00
IUUC-Csa-024272	Chlorocebus sabaeus	77.85	0.00e+00	847.00
IUUC-Cho-025051	Choloepus hoffmanni	78.98	9.00e-163	566.00
IUUC-Dno-029856	Dasypus novemcinctus	79.63	0.00e+00	1056.00
IUUC-Eca-033851	Equus caballus	74.47	0.00e+00	928.00
IUUC-Fal-037290	Ficedula albicollis	83.77	0.00e+00	1066.00
IUUC-Gmo-039249	Gadus morhua	78.62	3.00e-148	518.00
IUUC-Gga-040383	Gallus gallus	88.73	0.00e+00	920.00
IUUC-Gac-042595	Gasterosteus aculeatus	62.70	0.00e+00	807.00
IUUC-Ggo-044979	Gorilla gorilla	80.46	0.00e+00	1065.00
IUUC-Hsa-046743	Homo sapiens	80.46	0.00e+00	1062.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	78.62	0.00e+00	1054.00
IUUC-Lch-050294	Latimeria chalumnae	82.54	0.00e+00	1073.00
IUUC-Loc-051961	Lepisosteus oculatus	71.22	0.00e+00	860.00
IUUC-Mcc-055048	Macaca mulatta	79.60	0.00e+00	1053.00
IUUC-Meu-055971	Macropus eugenii	73.32	2.00e-175	608.00
IUUC-Mga-059720	Meleagris gallopavo	91.33	0.00e+00	914.00
IUUC-Mdo-062073	Monodelphis domestica	87.95	0.00e+00	1235.00
IUUC-Mmu-064095	Mus musculus	77.68	0.00e+00	1039.00
IUUC-Mlu-067090	Myotis lucifugus	76.61	0.00e+00	1014.00
IUUC-Nle-069486	Nomascus leucogenys	80.17	0.00e+00	1062.00
IUUC-Opr-070563	Ochotona princeps	77.52	0.00e+00	1037.00
IUUC-Ont-072103	Oreochromis niloticus	63.32	0.00e+00	820.00
IUUC-Ocu-074851	Oryctolagus cuniculus	76.88	0.00e+00	831.00
IUUC-Ola-086413	Oryzias latipes	57.45	0.00e+00	689.00
IUUC-Oga-088862	Otolemur garnettii	78.48	0.00e+00	1052.00
IUUC-Oar-089462	Ovis aries	80.73	0.00e+00	715.00
IUUC-Ptr-091525	Pan troglodytes	80.31	0.00e+00	961.00
IUUC-Pan-092363	Papio anubis	80.45	0.00e+00	1026.00
IUUC-Psi-093353	Pelodiscus sinensis	92.55	0.00e+00	1281.00
IUUC-Pfo-096413	Poecilia formosa	63.94	0.00e+00	824.00
IUUC-Pab-098592	Pongo abelii	77.68	0.00e+00	850.00
IUUC-Pca-100449	Procavia capensis	79.08	0.00e+00	1048.00
IUUC-Pva-102868	Pteropus vampyrus	78.62	0.00e+00	1028.00
IUUC-Rno-105190	Rattus norvegicus	77.04	0.00e+00	1039.00
IUUC-Sha-107337	Sarcophilus harrisii	88.73	0.00e+00	1215.00
IUUC-Sar-113561	Sorex araneus	88.02	4.00e-87	314.00
IUUC-Ssc-115735	Sus scrofa	78.19	0.00e+00	1019.00
IUUC-Tgu-117025	Taeniopygia guttata	78.49	0.00e+00	980.00
IUUC-Tru-117585	Takifugu rubripes	64.16	0.00e+00	801.00
IUUC-Tsy-118814	Tarsius syrichta	79.77	0.00e+00	1061.00
IUUC-Tni-120600	Tetraodon nigroviridis	63.73	0.00e+00	768.00
IUUC-Xtr-132090	Xenopus tropicalis	74.72	0.00e+00	1014.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence