iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037290

Ensembl Protein ID

ENSFALP00000003067.1

UniProt Accession

U3JJW3; U3JJW3_FICAL

Genbank Protein ID

ENSFALP00000003067

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTO01001859

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000002945.1	ENSFALT00000003080.1	ENSFALP00000003067.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.10e-100	334.9	253	656

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+           +++    +                                       
   Q: 253  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlceteeLLAKTV----Ngrarmpgklangaaanepgkpdrvgsspaglngggssis 337
           7******************************88875554333344....2555599999999999999********************* PP
   S: 43   ...........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeee 120
                      ++++ +l+++l++lf+ +w++++  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         e+e+
   Q: 338  rsleliqpkepSSKHISLCHELHTLFRVMWSGRWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLDKVQQEL---------ESEG 417
           ****999999999999************************************************************.........6788 PP
   S: 121  edkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeee 199
           ++++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e 
   Q: 418  TKRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCRTCNYKSNTVEPFWDLSLEFPERYHSLERgllplgqaecLLTEMLAKFTETEA 506
           899999999**************************************************987666************************ PP
   S: 200  legenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke... 274
           leg+  y c++c++k++           a+k+l + +lP+vL lhLkRf++se+ ++reki  +v f + Ld++p+c++++  +     
   Q: 507  LEGRI-YACDQCNSKRRksspkplvlseAKKQLLIYRLPQVLRLHLKRFRWSER-NHREKIGVHVLFEQVLDMEPYCCRDCLPSLGaag 593
           **965.*******9999999*******************************997.8889********************6655444555 PP
   S: 275  kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +  Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++r
   Q: 594  SFVYDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQR 656
           ****************************9999********************...********985 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWHCVDCH TTESLWACLK CSHVACGRYI EEHALRHFQE 60
SRHPLAMEVH ELYVFCYLCQ DYVLNDNPEG DLKLLRSSLS AIKGQRSGRT LRSTAPGEDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAAATGTG CTTTATTTAA TGTGGCACCA ATTCCCACAG GTTCTGTGCT TCACTTCTGC 60
CATTCCCAGG AGAGGGGGAA GGAATGAGTG AAAAAAAATC CTTCAATCTG AGCTTCCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

fab:101820838

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003658	Anas platyrhynchos	88.36	0.00e+00	1187.00
IUUC-Aca-005278	Anolis carolinensis	83.77	0.00e+00	1157.00
IUUC-Bta-012911	Bos taurus	74.89	0.00e+00	946.00
IUUC-Cja-019171	Callithrix jacchus	75.98	0.00e+00	986.00
IUUC-Cfa-020408	Canis familiaris	75.07	0.00e+00	964.00
IUUC-Cpo-022233	Cavia porcellus	72.86	0.00e+00	920.00
IUUC-Csa-024272	Chlorocebus sabaeus	76.03	0.00e+00	812.00
IUUC-Cho-025051	Choloepus hoffmanni	78.06	4.00e-159	554.00
IUUC-Dno-029856	Dasypus novemcinctus	76.54	0.00e+00	979.00
IUUC-Eca-033851	Equus caballus	72.10	0.00e+00	876.00
IUUC-Gmo-039249	Gadus morhua	78.37	1.00e-146	513.00
IUUC-Gga-040383	Gallus gallus	86.89	0.00e+00	878.00
IUUC-Gac-042595	Gasterosteus aculeatus	63.33	0.00e+00	796.00
IUUC-Ggo-044979	Gorilla gorilla	77.29	0.00e+00	992.00
IUUC-Hsa-046743	Homo sapiens	77.15	0.00e+00	991.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	76.10	0.00e+00	981.00
IUUC-Lch-050294	Latimeria chalumnae	78.93	0.00e+00	1008.00
IUUC-Loc-051961	Lepisosteus oculatus	74.09	0.00e+00	674.00
IUUC-Mcc-055048	Macaca mulatta	76.86	0.00e+00	988.00
IUUC-Meu-055971	Macropus eugenii	69.80	6.00e-166	577.00
IUUC-Mga-059720	Meleagris gallopavo	90.14	0.00e+00	879.00
IUUC-Mdo-062073	Monodelphis domestica	83.07	0.00e+00	1144.00
IUUC-Mmu-064095	Mus musculus	75.62	0.00e+00	982.00
IUUC-Mlu-067090	Myotis lucifugus	74.38	0.00e+00	951.00
IUUC-Nle-069486	Nomascus leucogenys	77.00	0.00e+00	990.00
IUUC-Opr-070563	Ochotona princeps	74.67	0.00e+00	969.00
IUUC-Ont-071637	Oreochromis niloticus	63.77	0.00e+00	808.00
IUUC-Ocu-074851	Oryctolagus cuniculus	74.57	0.00e+00	784.00
IUUC-Ola-086413	Oryzias latipes	60.26	0.00e+00	729.00
IUUC-Oga-088862	Otolemur garnettii	76.56	0.00e+00	981.00
IUUC-Ptr-091525	Pan troglodytes	76.97	0.00e+00	900.00
IUUC-Pan-092363	Papio anubis	77.69	0.00e+00	971.00
IUUC-Psi-093353	Pelodiscus sinensis	86.73	0.00e+00	1167.00
IUUC-Pfo-096413	Poecilia formosa	64.69	0.00e+00	825.00
IUUC-Pab-098592	Pongo abelii	75.86	0.00e+00	807.00
IUUC-Pca-100449	Procavia capensis	76.78	0.00e+00	984.00
IUUC-Pva-102868	Pteropus vampyrus	74.93	0.00e+00	955.00
IUUC-Rno-105190	Rattus norvegicus	75.91	0.00e+00	984.00
IUUC-Sha-107337	Sarcophilus harrisii	81.91	0.00e+00	1134.00
IUUC-Sar-113561	Sorex araneus	86.36	1.00e-76	280.00
IUUC-Ssc-115735	Sus scrofa	75.22	0.00e+00	949.00
IUUC-Tgu-117025	Taeniopygia guttata	88.11	0.00e+00	1091.00
IUUC-Tru-117585	Takifugu rubripes	65.40	0.00e+00	801.00
IUUC-Tsy-118814	Tarsius syrichta	77.13	0.00e+00	979.00
IUUC-Tni-120600	Tetraodon nigroviridis	64.41	0.00e+00	767.00
IUUC-Xtr-132090	Xenopus tropicalis	75.11	0.00e+00	998.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence