iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000012421.3	ENSMMUT00000017411.3	ENSMMUP00000016305.2
ENSMMUG00000012421.3	ENSMMUT00000074719.1	ENSMMUP00000055411.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.50e-98	328.9	253	656

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp............................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+ +++k+++  p                                               
   Q: 253  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPkatngktqlsgkptnssatelslrsdraeaceregfcwnggasisrs 341
           7******************************7777777777777777888999999999999999999999999999999999999999 PP
   S: 43   .........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeed 122
                    ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++
   Q: 342  leliqnkepSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTT 421
           99999999989999************************************************************.........668888 PP
   S: 123  kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeele 201
           ++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e le
   Q: 422  RRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALE 510
           8999999***************************************************998879************************* PP
   S: 202  genkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkk 277
           g+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  
   Q: 511  GRI-YACDQCNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDMLSSLDkeTFA 597
           965.*******9999999*******************************997.8889********************876654433999 PP
   S: 278  YeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 598  YDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 656
           *************************9999********************...********98 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCLECA TTESVWACLK CSHVACGRYI EDHALKHFEE 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDTL VRRGRTLRST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGGAACT CTGTGTGAGT ACACTAAAAA TTATCAGGTT TTTACTTTAC ACGAGTGAAT 60
TTTATGGCAT GTAAACTACC AATAATTTTT TTTAGTTTTT AAAAAGTATC AAAATATATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	95.54	0.00e+00	851.00
IUUC-Apl-003658	Anas platyrhynchos	78.88	0.00e+00	1053.00
IUUC-Aca-005278	Anolis carolinensis	79.60	0.00e+00	1076.00
IUUC-Bta-012911	Bos taurus	90.55	0.00e+00	1147.00
IUUC-Cja-019171	Callithrix jacchus	97.67	0.00e+00	1291.00
IUUC-Cfa-020408	Canis familiaris	91.12	0.00e+00	1186.00
IUUC-Cpo-022233	Cavia porcellus	84.42	0.00e+00	1083.00
IUUC-Csa-024272	Chlorocebus sabaeus	99.83	0.00e+00	1089.00
IUUC-Cho-025051	Choloepus hoffmanni	90.57	0.00e+00	655.00
IUUC-Cin-025587	Ciona intestinalis	47.86	8.00e-106	378.00
IUUC-Dno-029856	Dasypus novemcinctus	91.70	0.00e+00	1204.00
IUUC-Ete-032761	Echinops telfairi	76.04	0.00e+00	867.00
IUUC-Eca-033851	Equus caballus	84.35	0.00e+00	1022.00
IUUC-Fca-035919	Felis catus	95.00	0.00e+00	795.00
IUUC-Fal-037290	Ficedula albicollis	76.86	0.00e+00	949.00
IUUC-Gmo-039249	Gadus morhua	77.36	1.00e-145	509.00
IUUC-Gac-042595	Gasterosteus aculeatus	59.15	0.00e+00	753.00
IUUC-Ggo-044979	Gorilla gorilla	98.55	0.00e+00	1310.00
IUUC-Hsa-046743	Homo sapiens	98.40	0.00e+00	1305.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	92.87	0.00e+00	1237.00
IUUC-Lch-050294	Latimeria chalumnae	76.22	0.00e+00	967.00
IUUC-Loc-051961	Lepisosteus oculatus	68.47	0.00e+00	811.00
IUUC-Laf-053819	Loxodonta africana	94.61	0.00e+00	851.00
IUUC-Meu-055971	Macropus eugenii	67.32	3.00e-148	518.00
IUUC-Mmr-061253	Microcebus murinus	79.39	3.00e-157	548.00
IUUC-Mdo-062073	Monodelphis domestica	82.61	0.00e+00	1102.00
IUUC-Mmu-064095	Mus musculus	91.56	0.00e+00	1218.00
IUUC-Mpu-066318	Mustela putorius furo	94.95	0.00e+00	868.00
IUUC-Mlu-067090	Myotis lucifugus	88.21	0.00e+00	1160.00
IUUC-Nle-069486	Nomascus leucogenys	99.13	0.00e+00	1317.00
IUUC-Opr-070563	Ochotona princeps	91.30	0.00e+00	1217.00
IUUC-Oan-073245	Ornithorhynchus anatinus	89.97	0.00e+00	627.00
IUUC-Ocu-074851	Oryctolagus cuniculus	91.13	0.00e+00	967.00
IUUC-Ola-086413	Oryzias latipes	59.28	0.00e+00	738.00
IUUC-Oga-088862	Otolemur garnettii	94.18	0.00e+00	1234.00
IUUC-Oar-089462	Ovis aries	90.39	0.00e+00	807.00
IUUC-Ptr-091525	Pan troglodytes	98.40	0.00e+00	1177.00
IUUC-Pan-092363	Papio anubis	100.00	0.00e+00	1274.00
IUUC-Psi-093353	Pelodiscus sinensis	80.77	0.00e+00	1073.00
IUUC-Pma-094155	Petromyzon marinus	59.73	9.00e-84	303.00
IUUC-Pfo-096413	Poecilia formosa	60.82	0.00e+00	779.00
IUUC-Pab-098592	Pongo abelii	98.09	0.00e+00	1066.00
IUUC-Pca-100449	Procavia capensis	91.16	0.00e+00	1217.00
IUUC-Pva-102868	Pteropus vampyrus	90.68	0.00e+00	1180.00
IUUC-Rno-105190	Rattus norvegicus	90.39	0.00e+00	1222.00
IUUC-Sha-107337	Sarcophilus harrisii	82.87	0.00e+00	1089.00
IUUC-Sar-113561	Sorex araneus	95.18	3.00e-94	338.00
IUUC-Ssc-115735	Sus scrofa	91.12	0.00e+00	1167.00
IUUC-Tgu-117025	Taeniopygia guttata	72.16	0.00e+00	876.00
IUUC-Tru-117585	Takifugu rubripes	60.22	0.00e+00	762.00
IUUC-Tsy-118814	Tarsius syrichta	94.61	0.00e+00	1244.00
IUUC-Xtr-132090	Xenopus tropicalis	71.33	0.00e+00	939.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence