iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093353

Ensembl Protein ID

ENSPSIP00000009707.1

UniProt Accession

K7FNU7; K7FNU7_PELSI

Genbank Protein ID

ENSPSIP00000009707

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGCU01135424

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000008829.1	ENSPSIT00000009754.1	ENSPSIP00000009707.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-98	330.5	261	666

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+           +++    +                                       
   Q: 261  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlceteeLLAKTV----Ngksrmsgklangsaanesgkndkmgsygrqslpiglngg 345
           7******************************88875555333344....245558999999999999999999**************** PP
   S: 43   ...............kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpke 116
                          ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         
   Q: 346  ssisrsleliqpkepSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLDKVQQEL--------- 425
           ****9999999999999999************************************************************......... PP
   S: 117  eeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesft 195
           e+e+++++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft
   Q: 426  ESEGTKRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCITCNYKSNTIEPFWDLSLEFPERYHSIEKgivpvnqtecMLTEMLAKFT 514
           6788899999999************************************************999876669******************* PP
   S: 196  keeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqk 273
           ++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ ++ 
   Q: 515  ETEALEGRI-YACDQCNSKRRksspkplvlseAKKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVLFDQVLNMEPYCCRDSLSSL 601
           ******965.*******9999999*******************************997.8889********************887765 PP
   S: 274  e..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           +  +  Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 602  DkeTFVYDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 666
           433899*************************9999********************...********98 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWHCKDCN TTESIWACLK CSHVACGRYI EEHALKHFEE 60
TKHPLAMEVH DLYVFCYLCE DYVLNDNPEG DLKLLRSSLS AIRIQKHDPS SARSGRTLRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTTTGAAG CTGTGCCGCT TTATGTGATG AAGACCTGAG TAGTAATTAA ATTCCTGAAG 60
AACTGCCAAG TCTGCTGTTG GCTGAAATGG GGATGTTCCA GGCTCTGGTC ATTGAGTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

pss:102445177

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003658	Anas platyrhynchos	94.27	0.00e+00	1301.00
IUUC-Aca-005278	Anolis carolinensis	92.55	0.00e+00	1311.00
IUUC-Ame-010986	Astyanax mexicanus	61.56	0.00e+00	822.00
IUUC-Bta-012911	Bos taurus	79.11	0.00e+00	1030.00
IUUC-Cja-019171	Callithrix jacchus	80.06	0.00e+00	1065.00
IUUC-Cfa-020408	Canis familiaris	79.63	0.00e+00	1051.00
IUUC-Cpo-022233	Cavia porcellus	74.29	0.00e+00	977.00
IUUC-Csa-024272	Chlorocebus sabaeus	78.91	0.00e+00	860.00
IUUC-Cho-025051	Choloepus hoffmanni	81.25	1.00e-168	586.00
IUUC-Cin-025587	Ciona intestinalis	48.20	2.00e-112	400.00
IUUC-Csv-025814	Ciona savignyi	43.68	1.00e-150	526.00
IUUC-Dre-027878	Danio rerio	60.33	0.00e+00	797.00
IUUC-Dno-029856	Dasypus novemcinctus	80.80	0.00e+00	1073.00
IUUC-Ete-032627	Echinops telfairi	61.97	0.00e+00	840.00
IUUC-Eca-033851	Equus caballus	74.96	0.00e+00	933.00
IUUC-Fca-036288	Felis catus	62.54	0.00e+00	848.00
IUUC-Fal-037290	Ficedula albicollis	86.73	0.00e+00	1099.00
IUUC-Gmo-039249	Gadus morhua	79.25	2.00e-151	529.00
IUUC-Gga-040383	Gallus gallus	92.31	0.00e+00	957.00
IUUC-Gac-042595	Gasterosteus aculeatus	63.27	0.00e+00	820.00
IUUC-Ggo-044979	Gorilla gorilla	81.64	0.00e+00	1080.00
IUUC-Hsa-046743	Homo sapiens	81.64	0.00e+00	1078.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	80.09	0.00e+00	1071.00
IUUC-Lch-050294	Latimeria chalumnae	84.48	0.00e+00	1090.00
IUUC-Loc-051961	Lepisosteus oculatus	71.45	0.00e+00	867.00
IUUC-Laf-054491	Loxodonta africana	63.58	0.00e+00	846.00
IUUC-Mcc-055048	Macaca mulatta	80.77	0.00e+00	1068.00
IUUC-Meu-055971	Macropus eugenii	74.46	1.00e-179	622.00
IUUC-Mga-059720	Meleagris gallopavo	94.35	0.00e+00	947.00
IUUC-Mmr-060885	Microcebus murinus	62.67	0.00e+00	864.00
IUUC-Mdo-062073	Monodelphis domestica	90.83	0.00e+00	1278.00
IUUC-Mmu-064095	Mus musculus	79.08	0.00e+00	1051.00
IUUC-Mlu-067090	Myotis lucifugus	77.65	0.00e+00	1030.00
IUUC-Nle-069486	Nomascus leucogenys	81.35	0.00e+00	1077.00
IUUC-Opr-070563	Ochotona princeps	78.40	0.00e+00	1050.00
IUUC-Ont-072103	Oreochromis niloticus	64.17	0.00e+00	841.00
IUUC-Ocu-074851	Oryctolagus cuniculus	77.95	0.00e+00	839.00
IUUC-Ola-086413	Oryzias latipes	66.42	0.00e+00	680.00
IUUC-Oga-088862	Otolemur garnettii	79.94	0.00e+00	1062.00
IUUC-Oar-089462	Ovis aries	82.95	0.00e+00	740.00
IUUC-Ptr-091525	Pan troglodytes	81.29	0.00e+00	972.00
IUUC-Pan-092363	Papio anubis	81.40	0.00e+00	1040.00
IUUC-Pma-094155	Petromyzon marinus	59.32	4.00e-84	304.00
IUUC-Pfo-096413	Poecilia formosa	64.86	0.00e+00	842.00
IUUC-Pab-098592	Pongo abelii	79.08	0.00e+00	860.00
IUUC-Pca-100449	Procavia capensis	80.11	0.00e+00	1057.00
IUUC-Pva-102868	Pteropus vampyrus	80.09	0.00e+00	1046.00
IUUC-Rno-105190	Rattus norvegicus	78.51	0.00e+00	1053.00
IUUC-Sha-107337	Sarcophilus harrisii	89.91	0.00e+00	1250.00
IUUC-Sar-113561	Sorex araneus	89.22	3.00e-88	318.00
IUUC-Ssc-115735	Sus scrofa	79.37	0.00e+00	1035.00
IUUC-Tgu-117025	Taeniopygia guttata	81.14	0.00e+00	1009.00
IUUC-Tru-117585	Takifugu rubripes	64.04	0.00e+00	813.00
IUUC-Tsy-118814	Tarsius syrichta	81.09	0.00e+00	1074.00
IUUC-Tni-120600	Tetraodon nigroviridis	63.64	0.00e+00	774.00
IUUC-Xtr-132090	Xenopus tropicalis	75.46	0.00e+00	1042.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence