iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107337

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEFK01166367

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000010951.1	ENSSHAT00000012902.1	ENSSHAP00000012797.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.00e-98	328.6	260	665

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+             l+++++                                       
   Q: 260  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlceteeL----LAKTANgksqmssklangsptdestrndriepcsrqglptglngg 344
           7******************************999744441....333333556678888889999999999999999999999999999 PP
   S: 43   ...............kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpke 116
                          ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         
   Q: 345  ssinrsleliqpkepSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLDKVQQEL--------- 424
           99999999999999989999************************************************************......... PP
   S: 117  eeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesft 195
           e+e+++++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft
   Q: 425  ESEGTKRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCITCNYKSNTIEPFWDLSLEFPERYHCIEKglvpfnqtecMLTEMLAKFT 513
           6788899999999***************************************************998779******************* PP
   S: 196  keeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqk 273
           ++e leg+  y c++c+++++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++ ++ 
   Q: 514  ETEALEGRI-YACDQCNSRRRksspkplilseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDTLSSL 600
           ******965.*******999999999999999***********************997.8889********************887765 PP
   S: 274  e..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           +  +  Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 601  DkeTFAYDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 665
           434899*************************9999********************...********98 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWHCMQCN TTESVWACLK CSHVACGRYI EEHAFKHFEE 60
TRHPLAMEVN DLYVFCYLCE DYVLNDNPEG DLKLLRSTLS AIRSQKQDLS ARSGRMLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCATTCTCCA ACTGATGAAC ATCTTCCACA AGTCTTCAAC ATCATTGATG AACATGGTTT 60
GTAGCAGTGG AAATATTAAA GAAGATGTAT TACCATCTGA TGCTGTACTG TAGGACCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003658	Anas platyrhynchos	88.43	0.00e+00	1192.00
IUUC-Aca-005278	Anolis carolinensis	88.73	0.00e+00	1216.00
IUUC-Bta-012911	Bos taurus	79.82	0.00e+00	1008.00
IUUC-Cja-019171	Callithrix jacchus	82.14	0.00e+00	1062.00
IUUC-Cfa-020408	Canis familiaris	80.97	0.00e+00	1031.00
IUUC-Cpo-022233	Cavia porcellus	75.76	0.00e+00	973.00
IUUC-Csa-024272	Chlorocebus sabaeus	80.55	0.00e+00	863.00
IUUC-Cho-025051	Choloepus hoffmanni	83.81	4.00e-175	607.00
IUUC-Cin-025587	Ciona intestinalis	46.91	2.00e-109	390.00
IUUC-Dno-029856	Dasypus novemcinctus	82.43	0.00e+00	1061.00
IUUC-Eca-033851	Equus caballus	75.98	0.00e+00	934.00
IUUC-Fal-037290	Ficedula albicollis	81.91	0.00e+00	1038.00
IUUC-Gmo-039249	Gadus morhua	78.30	2.00e-149	522.00
IUUC-Gga-040383	Gallus gallus	86.42	0.00e+00	881.00
IUUC-Gac-042595	Gasterosteus aculeatus	63.09	0.00e+00	808.00
IUUC-Ggo-044979	Gorilla gorilla	83.16	0.00e+00	1069.00
IUUC-Hsa-046743	Homo sapiens	83.16	0.00e+00	1066.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	82.43	0.00e+00	1065.00
IUUC-Lch-050294	Latimeria chalumnae	82.32	0.00e+00	1050.00
IUUC-Loc-051961	Lepisosteus oculatus	72.46	0.00e+00	687.00
IUUC-Mcc-055048	Macaca mulatta	82.87	0.00e+00	1064.00
IUUC-Meu-055971	Macropus eugenii	81.78	0.00e+00	681.00
IUUC-Mga-059720	Meleagris gallopavo	89.23	0.00e+00	877.00
IUUC-Mdo-062073	Monodelphis domestica	97.54	0.00e+00	1347.00
IUUC-Mmu-064095	Mus musculus	79.65	0.00e+00	1044.00
IUUC-Mlu-067090	Myotis lucifugus	79.94	0.00e+00	1024.00
IUUC-Nle-069486	Nomascus leucogenys	82.87	0.00e+00	1063.00
IUUC-Opr-070563	Ochotona princeps	80.17	0.00e+00	1044.00
IUUC-Ocu-074851	Oryctolagus cuniculus	78.94	0.00e+00	835.00
IUUC-Ola-086413	Oryzias latipes	59.74	0.00e+00	768.00
IUUC-Oga-088862	Otolemur garnettii	82.22	0.00e+00	1052.00
IUUC-Ptr-091525	Pan troglodytes	82.36	0.00e+00	971.00
IUUC-Pan-092363	Papio anubis	83.01	0.00e+00	1047.00
IUUC-Psi-093353	Pelodiscus sinensis	89.91	0.00e+00	1219.00
IUUC-Pma-094155	Petromyzon marinus	58.25	2.00e-83	301.00
IUUC-Pfo-096413	Poecilia formosa	63.87	0.00e+00	824.00
IUUC-Pab-098592	Pongo abelii	80.03	0.00e+00	857.00
IUUC-Pca-100449	Procavia capensis	81.43	0.00e+00	1039.00
IUUC-Pva-102868	Pteropus vampyrus	81.11	0.00e+00	1029.00
IUUC-Rno-105190	Rattus norvegicus	79.80	0.00e+00	1041.00
IUUC-Sar-113561	Sorex araneus	94.12	3.00e-86	311.00
IUUC-Ssc-115735	Sus scrofa	80.82	0.00e+00	1023.00
IUUC-Tgu-117025	Taeniopygia guttata	77.16	0.00e+00	955.00
IUUC-Tru-117585	Takifugu rubripes	62.97	0.00e+00	786.00
IUUC-Tsy-118814	Tarsius syrichta	81.70	0.00e+00	1040.00
IUUC-Tni-120600	Tetraodon nigroviridis	62.23	0.00e+00	758.00
IUUC-Xtr-132090	Xenopus tropicalis	74.00	0.00e+00	995.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence