iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117585

UUCD1 version

UUC-TaR-01134

Ensembl Protein ID

ENSTRUP00000022197.1

UniProt Accession

H2TC05; H2TC05_TAKRU

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

usp49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000008833.1	ENSTRUT00000022286.1	ENSTRUP00000022196.1
ENSTRUG00000008833.1	ENSTRUT00000022287.1	ENSTRUP00000022197.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-97	328.2	262	671

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenp........................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+    +++e l+++n+                                           
   Q: 262  TGLRNLGNTCYMNSILQVLSHLRKFRECFLTldlcETEELLAKSNHtqgvkgvtgavvsngntalsgcplgrignlpvgrkesappstq 350
           7******************************999755555555555888999999**************************99999999 PP
   S: 43   .............kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeee 118
                        + ++ +l+ +l++lf+ +w+++++ vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         ++
   Q: 351  aaelvqakasrcsTRQQMSLCYELHTLFRVMWSGRWSLVSPFAMLHSVWNLIPAFRGYDQQDAQEFLCELLDKVQQEL---------DT 430
           999999999999888888************************************************************.........77 PP
   S: 119  eeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...........slqdcLesftk 196
           e+++++    + ++k  k+  ++++++F+gql sq++cl+c+++s++ epf+dlsl++p++ ++ k            +l+++L++ft+
   Q: 431  EGSRRRIVIPITKRKLSKQVLKVLNTIFHGQLLSQVTCLSCKHKSNTVEPFWDLSLEFPERYHSVKGsgsssayqrscTLTEMLSKFTE 519
           88888899999************************************************999875559********************* PP
   S: 197  eeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke 274
            e leg n y c++c+kk++           a k+l + +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++ +  + +
   Q: 520  MEALEG-NIYACNHCNKKRRksshkplvlseACKQLLIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVAFDQVLNIKPYCCTGSGHSVH 606
           *****9.77*********999*********************************997.8889*****************9995554433 PP
   S: 275  ..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
              ++Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Ds+ ++++ eev++   ++aY+lfY++r
   Q: 607  rgGYTYDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSEMKVCSVEEVCN---TQAYILFYTQR 671
           679***************************9999********************...********985 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

LEEMDRCKHV GRLRLGHDHS ILNPQKWQCV DCSTTDSVWA CLKCSHVACG RFMEEHSLKH 60
FQESRHPLAM EVRELDVFCF ACGDYVLNDN AEGDLKLLRG ALSTVRRPGT RSLRSSAGGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAGAGGAGA TGGATCGCTG TAAGCACGTG GGACGCCTCC GCCTGGGCCA CGACCATTCC 60
ATCCTCAACC CGCAGAAATG GCAGTGTGTG GACTGCAGCA CCACCGACTC GGTGTGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003658	Anas platyrhynchos	64.36	0.00e+00	826.00
IUUC-Aca-005278	Anolis carolinensis	64.16	0.00e+00	824.00
IUUC-Ame-011403	Astyanax mexicanus	70.72	0.00e+00	850.00
IUUC-Bta-012911	Bos taurus	67.61	2.00e-167	582.00
IUUC-Cja-019171	Callithrix jacchus	61.76	0.00e+00	784.00
IUUC-Cfa-020408	Canis familiaris	68.32	1.00e-167	583.00
IUUC-Cpo-022233	Cavia porcellus	70.36	3.00e-169	588.00
IUUC-Cho-025051	Choloepus hoffmanni	61.68	3.00e-124	439.00
IUUC-Csv-025814	Ciona savignyi	48.94	8.00e-107	381.00
IUUC-Dre-027577	Danio rerio	71.34	0.00e+00	880.00
IUUC-Dno-029856	Dasypus novemcinctus	67.52	4.00e-169	588.00
IUUC-Eca-033851	Equus caballus	56.75	0.00e+00	702.00
IUUC-Fal-037290	Ficedula albicollis	64.82	0.00e+00	770.00
IUUC-Gmo-039249	Gadus morhua	89.66	5.00e-171	594.00
IUUC-Gac-042595	Gasterosteus aculeatus	85.52	0.00e+00	1120.00
IUUC-Ggo-044979	Gorilla gorilla	61.19	0.00e+00	772.00
IUUC-Hsa-046743	Homo sapiens	61.71	0.00e+00	771.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	57.85	0.00e+00	745.00
IUUC-Lch-050294	Latimeria chalumnae	65.56	0.00e+00	798.00
IUUC-Loc-051961	Lepisosteus oculatus	77.10	0.00e+00	707.00
IUUC-Mcc-055048	Macaca mulatta	59.55	0.00e+00	770.00
IUUC-Meu-055971	Macropus eugenii	50.21	4.00e-105	375.00
IUUC-Mdo-062073	Monodelphis domestica	63.45	0.00e+00	815.00
IUUC-Mmu-064095	Mus musculus	61.97	0.00e+00	777.00
IUUC-Mlu-067090	Myotis lucifugus	69.05	1.00e-168	587.00
IUUC-Nle-069486	Nomascus leucogenys	61.33	0.00e+00	772.00
IUUC-Opr-070563	Ochotona princeps	61.06	0.00e+00	765.00
IUUC-Ont-072103	Oreochromis niloticus	87.44	0.00e+00	1137.00
IUUC-Ola-086413	Oryzias latipes	78.31	0.00e+00	1031.00
IUUC-Oga-088862	Otolemur garnettii	60.49	0.00e+00	772.00
IUUC-Ptr-091525	Pan troglodytes	59.19	0.00e+00	710.00
IUUC-Pan-092363	Papio anubis	60.20	0.00e+00	768.00
IUUC-Psi-093353	Pelodiscus sinensis	64.09	0.00e+00	829.00
IUUC-Pfo-096413	Poecilia formosa	88.46	0.00e+00	1149.00
IUUC-Pva-102868	Pteropus vampyrus	70.26	3.00e-170	592.00
IUUC-Rno-105190	Rattus norvegicus	62.08	0.00e+00	781.00
IUUC-Sha-107337	Sarcophilus harrisii	63.31	0.00e+00	811.00
IUUC-Sar-113561	Sorex araneus	81.62	2.00e-65	243.00
IUUC-Ssc-115727	Sus scrofa	69.42	2.00e-165	575.00
IUUC-Tgu-117025	Taeniopygia guttata	59.13	0.00e+00	689.00
IUUC-Tsy-118814	Tarsius syrichta	59.15	0.00e+00	768.00
IUUC-Tni-120600	Tetraodon nigroviridis	90.77	0.00e+00	1075.00
IUUC-Xtr-132090	Xenopus tropicalis	64.35	0.00e+00	820.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence