iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028403

Ensembl Protein ID

ENSDARP00000122829.1

UniProt Accession

Q6PC73; Q6PC73_DANRE

Genbank Protein ID

AAH59450.1

Protein Name

Growth factor receptor-bound protein 2; Growth factor receptor-bound protein 2b

Genbank Nucleotide ID

BX465842

Gene Name

grb2b; grb2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000038059.5	ENSDART00000147322.2	ENSDARP00000122829.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.80e-36	124.2	158	214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
             +vq+l+d+++q+d+eL +++Gd+++v+  ++ d +W+kg    +g+ G+fP n+v+ ++
   Q: 158  PTYVQALFDFDPQEDGELGFRRGDFIQVL--DNSDPNWWKG--ACHGQTGMFPRNYVTPVN 214
           579**************************..9*********..8**************997 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MEAIAKYDFK ATADDELSFK RGEILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKAHPW 60
FFGRIPRARA EEILNKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAGAGGAA ACGGAAATAA ACAGAAAAAT ACAGCAATTT TCACGATTTC GCGTCGGGCG 60
AGGTACAAGA GCTCTACTCC AGCAACGATT AAAGACCAAT AAGCGTGGAT TCTGCGTTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-0675--Receptor
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

dre:406308

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001345	Ailuropoda melanoleuca	94.27	1.00e-109	388.00
IUUC-Apl-003322	Anas platyrhynchos	95.29	9.00e-110	389.00
IUUC-Aca-005193	Anolis carolinensis	94.93	2.00e-124	437.00
IUUC-Bta-012932	Bos taurus	94.93	2.00e-124	437.00
IUUC-Cja-019225	Callithrix jacchus	94.93	2.00e-124	437.00
IUUC-Cfa-020887	Canis familiaris	94.93	2.00e-124	437.00
IUUC-Cpo-022488	Cavia porcellus	94.93	2.00e-124	437.00
IUUC-Csa-023326	Chlorocebus sabaeus	94.93	2.00e-124	437.00
IUUC-Cho-024953	Choloepus hoffmanni	77.88	7.00e-94	336.00
IUUC-Cin-025144	Ciona intestinalis	62.74	2.00e-73	268.00
IUUC-Dno-029187	Dasypus novemcinctus	94.47	7.00e-124	436.00
IUUC-Dor-030763	Dipodomys ordii	94.93	2.00e-124	437.00
IUUC-Dme-031741	Drosophila melanogaster	66.04	1.00e-78	285.00
IUUC-Ete-032354	Echinops telfairi	67.59	3.00e-79	287.00
IUUC-Eca-033222	Equus caballus	94.93	2.00e-124	437.00
IUUC-Eeu-034513	Erinaceus europaeus	69.12	2.00e-83	301.00
IUUC-Fca-036294	Felis catus	94.93	2.00e-124	437.00
IUUC-Fal-037130	Ficedula albicollis	94.47	5.00e-123	433.00
IUUC-Gmo-039546	Gadus morhua	94.93	2.00e-124	437.00
IUUC-Gga-041139	Gallus gallus	95.39	1.00e-124	438.00
IUUC-Gac-041968	Gasterosteus aculeatus	95.85	3.00e-126	444.00
IUUC-Ggo-044562	Gorilla gorilla	94.93	2.00e-124	437.00
IUUC-Hsa-046730	Homo sapiens	94.93	2.00e-124	437.00
IUUC-Itr-049025	Ictidomys tridecemlineatus	94.93	2.00e-124	437.00
IUUC-Loc-052723	Lepisosteus oculatus	96.31	5.00e-127	446.00
IUUC-Laf-053774	Loxodonta africana	93.55	3.00e-123	433.00
IUUC-Mcc-054603	Macaca mulatta	94.93	2.00e-124	437.00
IUUC-Meu-056173	Macropus eugenii	78.80	2.00e-98	351.00
IUUC-Mga-059950	Meleagris gallopavo	95.39	1.00e-124	438.00
IUUC-Mmr-060878	Microcebus murinus	94.93	2.00e-124	437.00
IUUC-Mdo-062454	Monodelphis domestica	95.39	1.00e-124	438.00
IUUC-Mmu-063913	Mus musculus	94.47	4.00e-124	436.00
IUUC-Mpu-066125	Mustela putorius furo	94.93	2.00e-124	437.00
IUUC-Mlu-068007	Myotis lucifugus	94.93	2.00e-124	437.00
IUUC-Nle-069101	Nomascus leucogenys	94.93	2.00e-124	437.00
IUUC-Opr-071075	Ochotona princeps	94.93	2.00e-124	437.00
IUUC-Oan-073107	Ornithorhynchus anatinus	50.44	2.00e-57	215.00
IUUC-Ocu-074583	Oryctolagus cuniculus	94.93	2.00e-124	437.00
IUUC-Ola-086586	Oryzias latipes	96.15	6.00e-87	314.00
IUUC-Oga-089047	Otolemur garnettii	94.93	2.00e-124	437.00
IUUC-Oar-089904	Ovis aries	88.07	2.00e-113	401.00
IUUC-Ptr-090678	Pan troglodytes	94.93	2.00e-124	437.00
IUUC-Pan-092090	Papio anubis	94.93	2.00e-124	437.00
IUUC-Psi-093765	Pelodiscus sinensis	95.39	9.00e-125	439.00
IUUC-Pfo-096131	Poecilia formosa	96.31	9.00e-127	445.00
IUUC-Pab-098709	Pongo abelii	94.93	2.00e-124	437.00
IUUC-Pca-100581	Procavia capensis	93.72	9.00e-109	385.00
IUUC-Pva-103066	Pteropus vampyrus	94.93	2.00e-124	437.00
IUUC-Rno-105224	Rattus norvegicus	94.93	2.00e-124	437.00
IUUC-Sha-107247	Sarcophilus harrisii	95.81	3.00e-110	390.00
IUUC-Sar-113277	Sorex araneus	79.72	1.00e-99	355.00
IUUC-Ssc-115478	Sus scrofa	94.93	2.00e-124	437.00
IUUC-Tgu-117479	Taeniopygia guttata	94.01	1.00e-122	431.00
IUUC-Tru-118451	Takifugu rubripes	86.90	4.00e-110	390.00
IUUC-Tsy-119029	Tarsius syrichta	88.75	7.00e-80	289.00
IUUC-Tbe-128097	Tupaia belangeri	94.47	2.00e-123	434.00
IUUC-Vpa-130754	Vicugna pacos	94.93	2.00e-124	437.00
IUUC-Xtr-132275	Xenopus tropicalis	89.52	5.00e-121	426.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence