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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045702
UUCD1 version UUC-HoS-00472
Ensembl Protein ID ENSP00000264607.4
UniProt Accession Q9Y576; A6NL50; Q4ZG29; Q9ULS4; ASB1_HUMAN
Genbank Protein ID AAD41894.1; AAX88934.1; AAH14528.1; BAA86460.1
Protein Name Ankyrin repeat and SOCS box protein 1
Genbank Nucleotide ID AF156777; AC016999; BC014528; AB032972
Gene Name ASB1; KIAA1146
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000065802.11 ENST00000264607.8 ENSP00000264607.4
ENSG00000065802.11 ENST00000409297.1 ENSP00000387025.1
ENSG00000065802.11 ENST00000438264.5 ENSP00000411773.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
iRefIndexPINAMentha
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 16325183
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 6.70e-16 59.6 287 335
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           + ++++rs pr+L +LCR+a+rr+lg++rl++i+ LPLP+ +k++Ll+e
   Q: 287  QVFKEARSVPRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
           578999*****************************************98 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MAEGGSPDGR AGPGSAGRNL KEWLREQFCD HPLEHCEDTR LHDAAYVGDL QTLRSLLQEE 60
SYRSRINEKS VWCCGWLPCT PLRIAATAGH GSCVDFLIRK GAEVDLVDVK GQTALYVAVV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045702|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGACTGCTGC CTCAGGCAAC GGGCTTTCCG ACTCCTTGGC TTCTTATGTG AGGAAACCAC 60
AGCGCGGCCG GCATCCAGAG AGTCGGTTAG CCGCGAAGTT CCCGCCGGAC GAAGGGACCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045702|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00969--SOCS_box
Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0030539--P:male genitalia development
GO:0042036--P:negative regulation of cytokine biosynthetic process
GO:0016567--P:protein ubiquitination
KEGG hsa:51665
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003665 Anas platyrhynchos 80.78 2.00e-156 544.00
IUUC-Aca-004334 Anolis carolinensis 78.21 1.00e-152 532.00
IUUC-Ame-011128 Astyanax mexicanus 69.38 7.00e-131 460.00
IUUC-Bta-012895 Bos taurus 96.85 0.00e+00 631.00
IUUC-Cja-019241 Callithrix jacchus 97.46 0.00e+00 634.00
IUUC-Cfa-020176 Canis familiaris 95.69 0.00e+00 634.00
IUUC-Cpo-022457 Cavia porcellus 93.71 2.00e-177 615.00
IUUC-Csa-024156 Chlorocebus sabaeus 98.81 0.00e+00 682.00
IUUC-Cho-024562 Choloepus hoffmanni 82.97 6.00e-150 523.00
IUUC-Cin-025660 Ciona intestinalis 31.80 2.00e-28 119.00
IUUC-Csv-025803 Ciona savignyi 34.39 7.00e-28 117.00
IUUC-Dre-027556 Danio rerio 61.11 6.00e-116 410.00
IUUC-Dno-029765 Dasypus novemcinctus 93.69 7.00e-178 616.00
IUUC-Dor-030466 Dipodomys ordii 94.83 7.00e-152 529.00
IUUC-Ete-032285 Echinops telfairi 89.63 2.00e-141 494.00
IUUC-Eca-033558 Equus caballus 95.95 0.00e+00 632.00
IUUC-Eeu-034701 Erinaceus europaeus 53.91 3.00e-20 92.40
IUUC-Fca-035479 Felis catus 95.58 2.00e-180 625.00
IUUC-Fal-037628 Ficedula albicollis 78.68 2.00e-142 498.00
IUUC-Gga-040606 Gallus gallus 82.39 2.00e-154 538.00
IUUC-Gac-042338 Gasterosteus aculeatus 68.54 1.00e-123 436.00
IUUC-Ggo-044559 Gorilla gorilla 97.59 0.00e+00 657.00
IUUC-Itr-048272 Ictidomys tridecemlineatus 95.61 0.00e+00 627.00
IUUC-Lch-049927 Latimeria chalumnae 73.54 2.00e-141 495.00
IUUC-Loc-052308 Lepisosteus oculatus 73.12 3.00e-138 484.00
IUUC-Laf-053811 Loxodonta africana 95.02 0.00e+00 626.00
IUUC-Mcc-055656 Macaca mulatta 99.10 0.00e+00 683.00
IUUC-Meu-055947 Macropus eugenii 89.59 4.00e-168 583.00
IUUC-Mga-059817 Meleagris gallopavo 81.37 4.00e-153 533.00
IUUC-Mmr-061051 Microcebus murinus 95.82 0.00e+00 656.00
IUUC-Mdo-062784 Monodelphis domestica 86.40 1.00e-166 579.00
IUUC-Mmu-063732 Mus musculus 94.64 9.00e-180 622.00
IUUC-Mpu-065987 Mustela putorius furo 96.21 0.00e+00 630.00
IUUC-Mlu-067362 Myotis lucifugus 94.95 2.00e-177 615.00
IUUC-Nle-069764 Nomascus leucogenys 99.40 0.00e+00 683.00
IUUC-Opr-070322 Ochotona princeps 90.75 2.00e-178 617.00
IUUC-Ont-072198 Oreochromis niloticus 68.75 3.00e-125 441.00
IUUC-Oan-073707 Ornithorhynchus anatinus 92.05 7.00e-82 295.00
IUUC-Ocu-074784 Oryctolagus cuniculus 91.93 7.00e-167 579.00
IUUC-Ola-086395 Oryzias latipes 67.91 5.00e-125 440.00
IUUC-Oga-088866 Otolemur garnettii 96.12 0.00e+00 661.00
IUUC-Oar-089242 Ovis aries 83.14 4.00e-153 533.00
IUUC-Ptr-091091 Pan troglodytes 100.00 0.00e+00 686.00
IUUC-Pan-091785 Papio anubis 99.10 0.00e+00 683.00
IUUC-Psi-092989 Pelodiscus sinensis 81.41 7.00e-122 429.00
IUUC-Pfo-096445 Poecilia formosa 68.44 5.00e-125 440.00
IUUC-Pab-097632 Pongo abelii 99.40 0.00e+00 683.00
IUUC-Pca-100870 Procavia capensis 91.18 2.00e-88 318.00
IUUC-Pva-103100 Pteropus vampyrus 92.74 3.00e-164 570.00
IUUC-Rno-105565 Rattus norvegicus 94.95 2.00e-180 624.00
IUUC-Sha-106839 Sarcophilus harrisii 85.03 4.00e-168 583.00
IUUC-Ssc-115713 Sus scrofa 95.90 0.00e+00 627.00
IUUC-Tgu-116989 Taeniopygia guttata 79.41 5.00e-124 436.00
IUUC-Tru-118293 Takifugu rubripes 67.70 1.00e-125 442.00
IUUC-Tsy-119534 Tarsius syrichta 87.82 1.00e-135 475.00
IUUC-Tni-119810 Tetraodon nigroviridis 67.61 7.00e-120 423.00
IUUC-Tbe-127798 Tupaia belangeri 95.94 1.00e-180 625.00
IUUC-Ttr-128625 Tursiops truncatus 96.47 7.00e-94 337.00
IUUC-Vpa-130038 Vicugna pacos 95.58 2.00e-180 624.00
IUUC-Xtr-132001 Xenopus tropicalis 61.95 3.00e-113 401.00
Created Date 25-Jun-2017

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