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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046263
UUCD1 version UUC-HoS-00408
Ensembl Protein ID ENSP00000471536.1
UniProt Accession Q9P0N8; A6NP10; Q5H785; Q8N5A3; Q96B78; MARH2_HUMAN
Genbank Protein ID BAD89359.1; AAF36160.1; AAH32624.1; AAH15910.1; AAI11389.1
Protein Name E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2
Genbank Nucleotide ID AB197929; AF151074; AC136469; BC015910; BC111388
Gene Name MARCH2; RNF172; HSPC240
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000099785.10 ENST00000381035.8 ENSP00000370423.3
ENSG00000099785.10 ENST00000601283.5 ENSP00000469386.1
ENSG00000099785.10 ENST00000602117.1 ENSP00000471536.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasemiRTarBasemicroRNA
TRANSFACTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17980554
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0028 19.8 64 109
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHv.....fhadClqkwpglknssskefrCPlC 45
           C iC+e    + l+ pCg +      h++Cl+kw     sss++ +C lC
   Q: 64   CRICHEGANGECLLSPCGCTgtlgaVHKSCLEKW----LSSSNTSYCELC 109
           ******99888999****98999*99********....88********** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
 E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.
Protein Sequence
(Fasta)
MTTGDCCHLP GSLCDCSGSP AFSKVVEATG LGPPQYVAQV TSRDGRLLST VIRALDTPSD 60
GPFCRICHEG ANGECLLSPC GCTGTLGAVH KSCLEKWLSS SNTSYCELCH TEFAVEKRPR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046263|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTCCGCGGC GCTGTCGGCT CGGCGGGCGG TGCCCGGACG CAGGTGCCGG CCGGAGCGGA 60
GCTAGTGGCG CCGACGGGCC GGGCCGGGCC GGGACCGGGG CCGAGGCGAA CCGAGGGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046263|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0254--Endocytosis
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51292--ZF_RING_CH
Pfam

PF12906--RINGv
SMART

SM00744--RINGv
Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0010008--C:endosome membrane
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0016567--P:protein ubiquitination
KEGG hsa:51257
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002189 Ailuropoda melanoleuca 95.53 3.00e-132 464.00
IUUC-Apl-004200 Anas platyrhynchos 82.01 1.00e-113 402.00
IUUC-Ame-010786 Astyanax mexicanus 78.86 2.00e-107 381.00
IUUC-Bta-012678 Bos taurus 93.09 1.00e-133 468.00
IUUC-Cja-019315 Callithrix jacchus 97.34 4.00e-107 380.00
IUUC-Cfa-020820 Canis familiaris 94.76 1.00e-136 478.00
IUUC-Cpo-021511 Cavia porcellus 94.31 2.00e-136 478.00
IUUC-Dre-028107 Danio rerio 77.11 4.00e-104 370.00
IUUC-Dno-029379 Dasypus novemcinctus 93.09 9.00e-124 436.00
IUUC-Dor-031059 Dipodomys ordii 93.50 3.00e-135 474.00
IUUC-Eca-034013 Equus caballus 90.65 1.00e-123 435.00
IUUC-Eeu-035139 Erinaceus europaeus 91.94 5.00e-63 232.00
IUUC-Fca-035894 Felis catus 95.53 2.00e-137 481.00
IUUC-Fal-037434 Ficedula albicollis 78.86 1.00e-104 372.00
IUUC-Gmo-039276 Gadus morhua 74.90 8.00e-104 369.00
IUUC-Gga-041224 Gallus gallus 80.49 7.00e-113 399.00
IUUC-Gac-042104 Gasterosteus aculeatus 73.39 2.00e-105 375.00
IUUC-Ggo-045297 Gorilla gorilla 100.00 3.00e-113 400.00
IUUC-Hvu-047389 Hordeum vulgare 25.41 6.00e-10 57.80
IUUC-Itr-048963 Ictidomys tridecemlineatus 94.72 3.00e-136 477.00
IUUC-Lch-050103 Latimeria chalumnae 79.67 3.00e-109 387.00
IUUC-Lpe-051137 Leersia perrieri 24.75 6.00e-11 61.20
IUUC-Loc-052480 Lepisosteus oculatus 70.73 2.00e-101 362.00
IUUC-Laf-054410 Loxodonta africana 94.31 5.00e-137 479.00
IUUC-Mcc-054712 Macaca mulatta 99.59 1.00e-143 501.00
IUUC-Mga-060053 Meleagris gallopavo 80.08 3.00e-115 407.00
IUUC-Mdo-062010 Monodelphis domestica 80.89 7.00e-118 416.00
IUUC-Mmu-064040 Mus musculus 92.28 9.00e-133 466.00
IUUC-Mpu-066205 Mustela putorius furo 95.12 3.00e-137 480.00
IUUC-Mlu-067013 Myotis lucifugus 89.96 2.00e-127 448.00
IUUC-Opr-070698 Ochotona princeps 70.73 2.00e-86 311.00
IUUC-Ont-071768 Oreochromis niloticus 75.00 5.00e-106 377.00
IUUC-Oan-073269 Ornithorhynchus anatinus 63.71 1.00e-85 308.00
IUUC-Ocu-074212 Oryctolagus cuniculus 94.31 6.00e-136 476.00
IUUC-Ogl-077311 Oryza glaberrima 27.64 1.00e-09 56.60
IUUC-Osa-085741 Oryza sativa 27.64 1.00e-09 56.60
IUUC-Ola-087137 Oryzias latipes 72.29 3.00e-93 334.00
IUUC-Oga-088712 Otolemur garnettii 95.53 7.00e-138 482.00
IUUC-Oar-090175 Ovis aries 93.09 8.00e-132 462.00
IUUC-Ptr-091210 Pan troglodytes 71.95 1.00e-89 321.00
IUUC-Pan-092276 Papio anubis 99.19 7.00e-143 499.00
IUUC-Psi-094007 Pelodiscus sinensis 80.49 7.00e-116 409.00
IUUC-Pfo-097509 Poecilia formosa 78.03 3.00e-100 357.00
IUUC-Pca-100424 Procavia capensis 92.28 4.00e-133 467.00
IUUC-Pva-102806 Pteropus vampyrus 94.31 6.00e-137 479.00
IUUC-Rno-105029 Rattus norvegicus 95.53 1.00e-136 478.00
IUUC-Sha-106628 Sarcophilus harrisii 80.89 1.00e-117 415.00
IUUC-Ssc-115689 Sus scrofa 95.93 2.00e-138 484.00
IUUC-Tgu-116681 Taeniopygia guttata 79.27 2.00e-114 404.00
IUUC-Tru-118517 Takifugu rubripes 71.77 2.00e-96 345.00
IUUC-Tni-120353 Tetraodon nigroviridis 68.67 8.00e-97 346.00
IUUC-Ttr-128265 Tursiops truncatus 95.93 3.00e-138 484.00
IUUC-Xtr-132814 Xenopus tropicalis 78.46 7.00e-110 389.00
Created Date 25-Jun-2017

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