iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000008259.6	ENSCAFT00000013136.6	ENSCAFP00000012157.5
ENSCAFG00000008259.6	ENSCAFT00000013145.3	ENSCAFP00000012164.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.30e-14	54.4	634	699

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggede.....k.....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++     +     +l+eC++C+e++Hp+Clk++     v++elpn+  w+CpkC+++
   Q: 634  AVCLVCGEAGKEDtveeeEgkfnlMLMECSICNEIIHPGCLKIKesegvVNDELPNC--WECPKCNHA 699
           79*********9977765156789*********************************..*******85 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MEAEKDSGRR LRPIDRQRYD ENEDLSDVEE IVSVRGFSLE EKLRSQLYQG DFVHAMEGKD 60
FNYEYVQREA LRVPLIFREK DGLGIKMPDP DFTVRDVKLL VGSRRLVDVM DVNTQKGTEM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGCAG AGAAAGACTC TGGAAGAAGA TTGGTGTGTA GCTTTTTTTT TTTTTTCCCC 60
AAATCTGTAT CTGGTAATGA TAGATCTATT TTTTTTTTTG TTGTTGTTGT TTCTTGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF02373--JmjC
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0031519--C:PcG protein complex
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0021592--P:fourth ventricle development
GO:0035518--P:histone H2A monoubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001358	Ailuropoda melanoleuca	99.24	0.00e+00	2334.00
IUUC-Apl-003787	Anas platyrhynchos	83.51	0.00e+00	1912.00
IUUC-Aca-004247	Anolis carolinensis	78.25	0.00e+00	1808.00
IUUC-Ame-011463	Astyanax mexicanus	74.93	2.00e-172	600.00
IUUC-Bta-013531	Bos taurus	97.40	0.00e+00	2350.00
IUUC-Cel-018303	Caenorhabditis elegans	44.86	1.00e-82	301.00
IUUC-Cja-018876	Callithrix jacchus	92.70	0.00e+00	2139.00
IUUC-Cpo-021967	Cavia porcellus	92.91	0.00e+00	2145.00
IUUC-Csa-023210	Chlorocebus sabaeus	96.53	0.00e+00	2251.00
IUUC-Dre-028272	Danio rerio	64.17	0.00e+00	1519.00
IUUC-Dno-030034	Dasypus novemcinctus	94.22	0.00e+00	2228.00
IUUC-Dor-030736	Dipodomys ordii	86.42	0.00e+00	996.00
IUUC-Eca-034255	Equus caballus	97.68	0.00e+00	2247.00
IUUC-Eeu-035038	Erinaceus europaeus	98.39	0.00e+00	1192.00
IUUC-Fca-035786	Felis catus	99.12	0.00e+00	2328.00
IUUC-Fal-037589	Ficedula albicollis	83.30	0.00e+00	2028.00
IUUC-Gmo-038781	Gadus morhua	62.80	0.00e+00	686.00
IUUC-Gga-041103	Gallus gallus	85.61	0.00e+00	1123.00
IUUC-Gac-041304	Gasterosteus aculeatus	62.74	0.00e+00	1505.00
IUUC-Ggo-044522	Gorilla gorilla	95.92	0.00e+00	1703.00
IUUC-Hsa-045877	Homo sapiens	96.61	0.00e+00	2256.00
IUUC-Itr-049003	Ictidomys tridecemlineatus	96.71	0.00e+00	1315.00
IUUC-Lch-049950	Latimeria chalumnae	77.47	0.00e+00	1894.00
IUUC-Loc-051972	Lepisosteus oculatus	75.75	0.00e+00	1078.00
IUUC-Laf-053623	Loxodonta africana	96.79	0.00e+00	2216.00
IUUC-Mcc-054943	Macaca mulatta	96.61	0.00e+00	2249.00
IUUC-Meu-056259	Macropus eugenii	85.45	0.00e+00	2048.00
IUUC-Mga-059671	Meleagris gallopavo	84.37	0.00e+00	1970.00
IUUC-Mmr-061003	Microcebus murinus	96.79	0.00e+00	2313.00
IUUC-Mmu-063584	Mus musculus	94.96	0.00e+00	2247.00
IUUC-Mpu-066056	Mustela putorius furo	99.47	0.00e+00	2342.00
IUUC-Mlu-067850	Myotis lucifugus	95.89	0.00e+00	2305.00
IUUC-Nle-069837	Nomascus leucogenys	93.36	0.00e+00	2013.00
IUUC-Opr-070943	Ochotona princeps	92.79	0.00e+00	2138.00
IUUC-Ont-071663	Oreochromis niloticus	65.55	0.00e+00	1576.00
IUUC-Oan-072934	Ornithorhynchus anatinus	75.49	0.00e+00	1256.00
IUUC-Ocu-074706	Oryctolagus cuniculus	96.30	0.00e+00	2306.00
IUUC-Ola-086543	Oryzias latipes	63.90	0.00e+00	1557.00
IUUC-Oga-088671	Otolemur garnettii	85.08	0.00e+00	1012.00
IUUC-Oar-089560	Ovis aries	92.72	0.00e+00	2254.00
IUUC-Ptr-090875	Pan troglodytes	96.77	0.00e+00	2287.00
IUUC-Pan-091788	Papio anubis	93.78	0.00e+00	2206.00
IUUC-Psi-093382	Pelodiscus sinensis	83.60	0.00e+00	2027.00
IUUC-Pma-094687	Petromyzon marinus	56.77	6.00e-91	328.00
IUUC-Pfo-096272	Poecilia formosa	62.35	0.00e+00	1503.00
IUUC-Pab-097907	Pongo abelii	92.30	0.00e+00	2110.00
IUUC-Pca-100628	Procavia capensis	87.15	0.00e+00	1858.00
IUUC-Pva-102956	Pteropus vampyrus	96.50	0.00e+00	1196.00
IUUC-Rno-105722	Rattus norvegicus	95.01	0.00e+00	1811.00
IUUC-Sha-106626	Sarcophilus harrisii	81.32	0.00e+00	1815.00
IUUC-Ssc-115918	Sus scrofa	96.49	0.00e+00	1763.00
IUUC-Tru-118638	Takifugu rubripes	69.32	0.00e+00	979.00
IUUC-Tsy-118820	Tarsius syrichta	91.91	0.00e+00	764.00
IUUC-Tbe-127654	Tupaia belangeri	79.76	0.00e+00	1682.00
IUUC-Ttr-128821	Tursiops truncatus	90.56	0.00e+00	2083.00
IUUC-Xtr-131823	Xenopus tropicalis	75.12	0.00e+00	1743.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence