iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-045912

Ensembl Protein ID

ENSP00000311962.4

UniProt Accession

Q9UJY4; D3DWF0; O14564; Q9NYN2; Q9UPS2; GGA2_HUMAN

Genbank Protein ID

AAF05708.1; AAF35394.1; AAF42806.1; AAC05813.1; EAW55827.1; EAW55828.1; AAH00284.1; AAK38634.1; BAA83032.1

Protein Name

ADP-ribosylation factor-binding protein GGA2; Gamma-adaptin-related protein 2; Golgi-localized, gamma ear-containing, ARF-binding protein 2; VHS domain and ear domain of gamma-adaptin

Genbank Nucleotide ID

AF190863; AF233522; AF165531; AC002400; CH471145; CH471145; BC000284; AF323754; AB029003

Gene Name

GGA2; KIAA1080

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000103365.15	ENST00000309859.8	ENSP00000311962.4
ENSG00000103365.15	ENST00000567468.5	ENSP00000454455.1
ENSG00000103365.15	ENST00000569300.5	ENSP00000455331.1
ENSG00000103365.15	ENST00000563047.1	ENSP00000455293.1
ENSG00000103365.15	ENST00000562944.5	ENSP00000459560.1
ENSG00000103365.15	ENST00000562117.1	ENSP00000459414.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/GAT	GAT	17494868

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/GAT	4.30e-50	170.7	188	315

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/GAT

   S: 1    deeksklLerLlkskkPeDLreAnkLikelvkededkaekikkliseleevksnvkllnemlselspegeepednellqelyetckaarpkl 92
           deeksklL+rLlks++PeDL++An+Lik+lvke+++k+ek++k++s++eev+s+vk+l+emls++++ g++p d+e+lq +ye+c+++rp+l
   Q: 188  DEEKSKLLTRLLKSNHPEDLQAANRLIKNLVKEEQEKSEKVSKRVSAVEEVRSHVKVLQEMLSMYRRPGQAPPDQEALQVVYERCEKLRPTL 279
           79****************************************************************************************** PP
   S: 93   lklieeeedndellaellkanDelnqvlnkykqlke 128
           ++l+++++d+d++lae+l+anD l+q ++ ykq++e
   Q: 280  FRLASDTTDDDDALAEILQANDLLTQGVLLYKQVME 315
           *********************************985 PP

Organism

Homo sapiens

Functional Description
(View)

Monomer. Interacts with NECAP1, TSG101, UBC and AFTPH/aftiphilin. Interacts with CNST (By similarity). Interacts with GGA1 and GGA3. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the type-I membrane proteins SORT1, SORL1, LRP3, M6PR/CD-MPR, IGF2R/CI-MPR and BACE1. Binds the accessory proteins CCDC91, P200, SYNRG, EPN4 and NECAP2.

Protein Sequence
(Fasta)

MAATAVAAAV AGTESAQGPP GPAASLELWL NKATDPSMSE QDWSAIQNFC EQVNTDPNGP 60
THAPWLLAHK IQSPQEKEAL YALTVLEMCM NHCGEKFHSE VAKFRFLNEL IKVLSPKYLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTCTGTTA CAGATATGGA AACCGAGGTT CTGAAAAGTT AACTAAAACT TCCGAGGTTA 60
TAGTACGAGG CAAAACCAAG ATTTAAACTC AGATCTGTGC CGATCCAGAG TCCAAGCTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR008152--Clathrin_a/b/g-adaptin_app_Ig
IPR008153--Clathrin_g-adaptin_app
IPR013041--Coatomer/clathrin_app_Ig-like
IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR002014--VHS_dom

PROSITE

PS50180--GAE
PS50909--GAT
PS50179--VHS

Pfam

PF02883--Alpha_adaptinC2
PF03127--GAT
PF00790--VHS

SMART

SM00809--Alpha_adaptinC2
SM00288--VHS

Gene Ontology

GO:0030131--C:clathrin adaptor complex
GO:0030136--C:clathrin-coated vesicle
GO:0031901--C:early endosome membrane
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0005802--C:trans-Golgi network
GO:0030306--F:ADP-ribosylation factor binding
GO:0044267--P:cellular protein metabolic process
GO:0006886--P:intracellular protein transport
GO:0061024--P:membrane organization
GO:0016192--P:vesicle-mediated transport

KEGG

hsa:23062

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001341	Ailuropoda melanoleuca	92.80	0.00e+00	1019.00
IUUC-Apl-003827	Anas platyrhynchos	47.15	2.00e-90	326.00
IUUC-Ani-009425	Aspergillus nidulans	26.33	1.00e-16	81.60
IUUC-Bgr-012048	Blumeria graminis	21.70	1.00e-21	98.20
IUUC-Bta-013492	Bos taurus	90.91	0.00e+00	998.00
IUUC-Bci-013954	Botrytis cinerea	23.99	1.00e-19	91.70
IUUC-Cja-018800	Callithrix jacchus	94.30	0.00e+00	1009.00
IUUC-Cfa-021014	Canis familiaris	90.86	0.00e+00	1023.00
IUUC-Cpo-021561	Cavia porcellus	91.68	0.00e+00	986.00
IUUC-Csa-024178	Chlorocebus sabaeus	97.83	0.00e+00	1103.00
IUUC-Cho-024564	Choloepus hoffmanni	77.55	4.00e-164	571.00
IUUC-Dno-029286	Dasypus novemcinctus	90.65	0.00e+00	974.00
IUUC-Dor-030125	Dipodomys ordii	83.26	1.00e-180	626.00
IUUC-Ete-032922	Echinops telfairi	79.63	0.00e+00	824.00
IUUC-Eca-034426	Equus caballus	93.31	0.00e+00	1080.00
IUUC-Eeu-034886	Erinaceus europaeus	73.19	7.00e-115	407.00
IUUC-Fca-035516	Felis catus	93.86	0.00e+00	1037.00
IUUC-Gga-040548	Gallus gallus	63.14	3.00e-108	385.00
IUUC-Ggo-044638	Gorilla gorilla	89.55	0.00e+00	975.00
IUUC-Itr-048824	Ictidomys tridecemlineatus	91.84	0.00e+00	1004.00
IUUC-Kpa-049359	Komagataella pastoris	23.31	3.00e-16	80.10
IUUC-Lma-053070	Leptosphaeria maculans	24.16	2.00e-18	87.80
IUUC-Laf-054401	Loxodonta africana	89.41	0.00e+00	966.00
IUUC-Mcc-055612	Macaca mulatta	97.02	0.00e+00	1090.00
IUUC-Mmr-061458	Microcebus murinus	88.68	0.00e+00	938.00
IUUC-Mdo-062796	Monodelphis domestica	66.50	0.00e+00	713.00
IUUC-Mmu-063380	Mus musculus	85.20	0.00e+00	890.00
IUUC-Mpu-066175	Mustela putorius furo	90.68	0.00e+00	937.00
IUUC-Mlu-068058	Myotis lucifugus	61.36	2.00e-135	476.00
IUUC-Nle-069012	Nomascus leucogenys	96.67	0.00e+00	1083.00
IUUC-Opr-070412	Ochotona princeps	79.73	0.00e+00	800.00
IUUC-Ocu-073919	Oryctolagus cuniculus	79.42	9.00e-159	553.00
IUUC-Oga-087960	Otolemur garnettii	91.43	0.00e+00	970.00
IUUC-Oar-089238	Ovis aries	91.08	0.00e+00	998.00
IUUC-Ptr-090778	Pan troglodytes	93.19	0.00e+00	1038.00
IUUC-Pan-092917	Papio anubis	97.67	0.00e+00	1102.00
IUUC-Psi-093912	Pelodiscus sinensis	52.57	4.00e-124	438.00
IUUC-Pfo-097063	Poecilia formosa	44.32	1.00e-115	410.00
IUUC-Pab-098685	Pongo abelii	95.17	0.00e+00	766.00
IUUC-Pca-100932	Procavia capensis	94.43	4.00e-136	478.00
IUUC-Pva-102575	Pteropus vampyrus	80.93	0.00e+00	851.00
IUUC-Pte-104353	Pyrenophora teres	22.81	1.00e-16	82.00
IUUC-Pyt-104704	Pyrenophora triticirepentis	22.06	1.00e-16	81.60
IUUC-Rno-105093	Rattus norvegicus	85.81	0.00e+00	904.00
IUUC-Sha-106784	Sarcophilus harrisii	67.66	0.00e+00	721.00
IUUC-Ssc-115750	Sus scrofa	81.16	5.00e-167	581.00
IUUC-Tgu-116453	Taeniopygia guttata	66.32	4.00e-101	360.00
IUUC-Tsy-119576	Tarsius syrichta	87.50	2.00e-108	386.00
IUUC-Tme-126920	Tuber melanosporum	24.10	1.00e-17	85.10
IUUC-Tbe-127374	Tupaia belangeri	93.21	0.00e+00	643.00
IUUC-Ttr-128868	Tursiops truncatus	88.27	0.00e+00	949.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence