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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046298
UUCD1 version UUC-HoS-00383
Ensembl Protein ID ENSP00000381226.2
UniProt Accession Q9NPC3; CIP1_HUMAN
Genbank Protein ID AAF36386.1; CAB82326.1; BAB15403.1; CAD61896.1; CAD61897.1; CAD62312.1; AAH00369.1; AAH01218.1; AAH04435.1
Protein Name E3 ubiquitin-protein ligase CCNB1IP1; Cyclin-B1-interacting protein 1; Human enhancer of invasion 10; RING-type E3 ubiquitin transferase CCNB1IP1
Genbank Nucleotide ID AF216381; AL161994; AK026233; BX161423; BX161424; BX247978; BC000369; BC001218; BC004435
Gene Name CCNB1IP1; C14orf18; HEI10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100814.17 ENST00000398160.6 ENSP00000381226.2
ENSG00000100814.17 ENST00000554184.5 ENSP00000451122.1
ENSG00000100814.17 ENST00000556854.5 ENSP00000452463.1
ENSG00000100814.17 ENST00000554047.1 ENSP00000450914.1
ENSG00000100814.17 ENST00000556563.5 ENSP00000452312.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17784788; 17297447
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 88.45 2.00e-135 479.00 IUUC-Mmu-063104
Organism Homo sapiens
Functional Description
(View)

Functional Description


     S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
 S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
Protein Sequence
(Fasta)
MSLCEDMLLC NYRKCRIKLS GYAWVTACSH IFCDQHGSGE FSRSPAICPA CNSTLSGKLD 60
IVRTELSPSE EYKAMVLAGL RPEIVLDISS RALAFWTYQV HQERLYQEYN FSKAEGHLKQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046298|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTCCCAAG GCGACTTCCT GTCTCTCCAC TTTCTTTCCC TCTCCGTTTT GGTGGGCTGG 60
TGAGTGTGCG CTTAATTTTG CTCTCTAATT GTTTTGAATT TCTCTTCCAT TTGAGTTATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046298|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF14634--zf-RING_5
Gene Ontology

GO:0000795--C:synaptonemal complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0001825--P:blastocyst formation
GO:0051026--P:chiasma assembly
GO:0016567--P:protein ubiquitination
GO:0007131--P:reciprocal meiotic recombination
GO:0007286--P:spermatid development
KEGG hsa:57820
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001494 Ailuropoda melanoleuca 95.31 1.00e-150 525.00
IUUC-Atr-002590 Amborella trichopoda 27.93 5.00e-17 81.60
IUUC-Aca-004727 Anolis carolinensis 76.26 5.00e-125 440.00
IUUC-Aly-005623 Arabidopsis lyrata 27.37 2.00e-16 80.10
IUUC-Ath-007676 Arabidopsis thaliana 27.37 2.00e-16 79.70
IUUC-Acl-008069 Aspergillus clavatus 28.93 1.00e-25 110.00
IUUC-Afl-008624 Aspergillus flavus 32.86 2.00e-14 72.00
IUUC-Afu-008843 Aspergillus fumigatus 21.35 6.00e-03 34.30
IUUC-Ang-009632 Aspergillus niger 29.12 1.00e-19 90.90
IUUC-Aor-010103 Aspergillus oryzae 26.15 1.00e-14 74.30
IUUC-Ame-011272 Astyanax mexicanus 68.36 2.00e-73 268.00
IUUC-Bgr-012009 Blumeria graminis 36.56 2.00e-27 116.00
IUUC-Bta-013554 Bos taurus 95.31 1.00e-159 555.00
IUUC-Bci-013777 Botrytis cinerea 32.98 1.00e-29 124.00
IUUC-Bdi-014526 Brachypodium distachyon 25.70 2.00e-15 76.30
IUUC-Bol-015609 Brassica oleracea 23.02 7.00e-11 61.60
IUUC-Bra-017490 Brassica rapa 22.76 7.00e-11 61.60
IUUC-Cja-019479 Callithrix jacchus 96.75 1.00e-152 532.00
IUUC-Cfa-020587 Canis familiaris 95.67 1.00e-150 526.00
IUUC-Cpo-022322 Cavia porcellus 93.86 7.00e-157 546.00
IUUC-Csa-023413 Chlorocebus sabaeus 98.92 3.00e-155 540.00
IUUC-Cho-024774 Choloepus hoffmanni 96.39 4.00e-152 530.00
IUUC-Cin-025768 Ciona intestinalis 37.30 3.00e-32 132.00
IUUC-Csv-025979 Ciona savignyi 49.09 1.00e-29 122.00
IUUC-Dre-027844 Danio rerio 52.11 1.00e-75 276.00
IUUC-Dno-029464 Dasypus novemcinctus 96.03 2.00e-152 531.00
IUUC-Ete-032388 Echinops telfairi 96.91 7.00e-55 207.00
IUUC-Eca-034091 Equus caballus 95.67 7.00e-150 522.00
IUUC-Eeu-034849 Erinaceus europaeus 98.99 8.00e-57 213.00
IUUC-Fca-036196 Felis catus 94.95 2.00e-159 555.00
IUUC-Fox-038053 Fusarium oxysporum 32.24 5.00e-26 110.00
IUUC-Fso-038281 Fusarium solani 30.83 1.00e-23 104.00
IUUC-Gmo-038640 Gadus morhua 72.40 3.00e-88 318.00
IUUC-Gac-042089 Gasterosteus aculeatus 63.40 2.00e-95 342.00
IUUC-Gma-043411 Glycine max 26.82 1.00e-14 73.60
IUUC-Ggo-044908 Gorilla gorilla 99.28 1.00e-155 541.00
IUUC-Hvu-047386 Hordeum vulgare 27.37 1.00e-16 79.70
IUUC-Itr-048597 Ictidomys tridecemlineatus 68.95 2.00e-106 379.00
IUUC-Lch-049554 Latimeria chalumnae 76.26 3.00e-113 400.00
IUUC-Lpe-051573 Leersia perrieri 26.26 2.00e-15 76.30
IUUC-Lma-052964 Leptosphaeria maculans 30.88 6.00e-16 79.70
IUUC-Laf-053637 Loxodonta africana 96.03 4.00e-154 536.00
IUUC-Mcc-055204 Macaca mulatta 98.56 9.00e-156 542.00
IUUC-Meu-055940 Macropus eugenii 95.07 9.00e-83 298.00
IUUC-Mpo-057618 Magnaporthe poae 27.41 2.00e-10 60.10
IUUC-Mtr-058578 Medicago truncatula 25.70 2.00e-15 76.30
IUUC-Mla-058981 Melampsora laricipopulina 33.51 3.00e-26 112.00
IUUC-Mvi-060402 Microbotryum violaceum 40.00 4.00e-25 109.00
IUUC-Mmr-061554 Microcebus murinus 96.03 2.00e-151 528.00
IUUC-Mdo-062669 Monodelphis domestica 89.17 1.00e-140 492.00
IUUC-Mmu-063104 Mus musculus 88.45 2.00e-145 508.00
IUUC-Mac-064933 Musa acuminata 29.61 3.00e-18 85.50
IUUC-Mpu-066581 Mustela putorius furo 95.67 8.00e-151 525.00
IUUC-Mlu-067434 Myotis lucifugus 93.86 8.00e-143 499.00
IUUC-Nfi-068592 Neosartorya fischeri 25.89 2.00e-15 76.30
IUUC-Ncr-068708 Neurospora crassa 31.11 7.00e-24 104.00
IUUC-Nle-070183 Nomascus leucogenys 98.92 1.00e-155 541.00
IUUC-Opr-070894 Ochotona princeps 93.86 1.00e-148 518.00
IUUC-Oan-072769 Ornithorhynchus anatinus 81.23 2.00e-136 478.00
IUUC-Ocu-073947 Oryctolagus cuniculus 94.22 4.00e-159 553.00
IUUC-Oba-075070 Oryza barthii 26.09 3.00e-16 79.70
IUUC-Obr-076808 Oryza brachyantha 26.82 1.00e-16 80.50
IUUC-Ogl-077330 Oryza glaberrima 26.26 4.00e-16 78.60
IUUC-Ogu-078072 Oryza glumaepatula 25.27 6.00e-11 61.60
IUUC-Oin-079403 Oryza indica 26.09 6.00e-16 78.60
IUUC-Ome-081922 Oryza meridionalis 21.79 3.00e-06 45.40
IUUC-Oni-082103 Oryza nivara 23.96 5.00e-04 38.10
IUUC-Opu-083915 Oryza punctata 24.31 4.00e-10 58.90
IUUC-Oru-085264 Oryza rufipogon 23.96 5.00e-04 38.10
IUUC-Osa-086002 Oryza sativa 26.26 4.00e-16 78.60
IUUC-Ola-087405 Oryzias latipes 78.72 1.00e-92 332.00
IUUC-Oga-088542 Otolemur garnettii 94.22 2.00e-148 517.00
IUUC-Oar-089270 Ovis aries 94.95 2.00e-159 554.00
IUUC-Ptr-090658 Pan troglodytes 99.64 2.00e-156 544.00
IUUC-Pan-092852 Papio anubis 97.85 3.00e-154 537.00
IUUC-Psi-093949 Pelodiscus sinensis 81.23 2.00e-136 478.00
IUUC-Pma-094220 Petromyzon marinus 48.42 6.00e-52 196.00
IUUC-Ppa-095443 Physcomitrella patens 27.47 1.00e-10 60.50
IUUC-Pfo-096277 Poecilia formosa 76.56 4.00e-91 327.00
IUUC-Pab-098550 Pongo abelii 99.64 1.00e-155 542.00
IUUC-Pop-099903 Populus trichocarpa 27.37 1.00e-16 80.10
IUUC-Pca-100150 Procavia capensis 96.03 8.00e-154 535.00
IUUC-Ppe-101240 Prunus persica 25.70 3.00e-16 79.00
IUUC-Pva-102742 Pteropus vampyrus 94.95 1.00e-151 528.00
IUUC-Pte-104396 Pyrenophora teres 28.79 3.00e-11 63.90
IUUC-Rno-105452 Rattus norvegicus 89.17 1.00e-146 512.00
IUUC-Sha-107359 Sarcophilus harrisii 88.45 4.00e-139 487.00
IUUC-Spo-108203 Schizosaccharomyces pombe 31.67 3.20e-02 33.10
IUUC-Ssl-108502 Sclerotinia sclerotiorum 33.83 1.00e-17 84.00
IUUC-Sit-110136 Setaria italica 27.68 2.00e-16 79.70
IUUC-Sly-111297 Solanum lycopersicum 25.48 1.00e-13 70.50
IUUC-Stu-112496 Solanum tuberosum 21.25 2.00e-03 36.20
IUUC-Sar-113186 Sorex araneus 92.78 4.00e-156 543.00
IUUC-Sbi-114871 Sorghum bicolor 26.26 2.00e-15 76.30
IUUC-Ssc-116149 Sus scrofa 95.67 8.00e-153 532.00
IUUC-Tsy-119353 Tarsius syrichta 100.00 6.00e-57 214.00
IUUC-Tni-120854 Tetraodon nigroviridis 74.11 4.00e-92 330.00
IUUC-Tca-121749 Theobroma cacao 27.37 5.00e-17 81.60
IUUC-Tre-122199 Trichoderma reesei 24.74 2.00e-03 34.70
IUUC-Tvi-122257 Trichoderma virens 29.52 2.00e-19 88.60
IUUC-Tae-125852 Triticum aestivum 27.37 5.00e-17 81.60
IUUC-Tme-126923 Tuber melanosporum 33.52 5.00e-26 112.00
IUUC-Tbe-127608 Tupaia belangeri 92.42 2.00e-146 511.00
IUUC-Ttr-128671 Tursiops truncatus 88.45 9.00e-145 505.00
IUUC-Vda-129697 Verticillium dahliae 33.15 7.00e-26 110.00
IUUC-Vpa-130711 Vicugna pacos 95.51 1.00e-89 321.00
IUUC-Vvi-131396 Vitis vinifera 25.00 3.00e-07 48.90
IUUC-Xtr-132491 Xenopus tropicalis 71.12 1.00e-113 402.00
IUUC-Xma-133340 Xiphophorus maculatus 72.99 1.00e-92 332.00
IUUC-Zma-134799 Zea mays 24.02 7.00e-14 71.20
Created Date 25-Jun-2017

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