iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065835

Ensembl Protein ID

ENSMPUP00000007497.1

UniProt Accession

M3Y840; M3Y840_MUSPF

Genbank Protein ID

ENSMPUP00000007497

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01078690

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000007553.1	ENSMPUT00000007617.1	ENSMPUP00000007497.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-119	399.1	1249	1584

Active Site

Position(s)	Description	Evidence
1552	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1249 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1334
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1335 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1417
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketky...kggytedspaiqwFwevleefssee 260
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y     gy++++ +i+wFw ++e+f++e+
   Q: 1418 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYrggSIGYHDNHIVIRWFWAAVERFNNEQ 1504
           ***********************************************************666668********************** PP
   S: 261  rkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           r ++LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1505 RLRLLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1584
           *****************************************************************************985 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMPEN MTLQRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTAGCT CGGCCCGGGA GCACCTGCTT TTTGTGCGGC GTCGAAATCC CCAGATGCGG 60
TACACACTGA GCCCCGAGAA CCTCCAGAGC CTGGCGGCCC AGAGCTCCAT GCCAGAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	83.70	0.00e+00	2556.00
IUUC-Apl-003935	Anas platyrhynchos	94.27	0.00e+00	1554.00
IUUC-Aca-004558	Anolis carolinensis	93.27	0.00e+00	1526.00
IUUC-Ame-010893	Astyanax mexicanus	87.87	0.00e+00	1286.00
IUUC-Bta-013093	Bos taurus	98.43	0.00e+00	1543.00
IUUC-Cja-019651	Callithrix jacchus	81.62	0.00e+00	2363.00
IUUC-Cfa-021232	Canis familiaris	95.84	0.00e+00	1545.00
IUUC-Cpo-021770	Cavia porcellus	94.71	0.00e+00	1563.00
IUUC-Csa-023970	Chlorocebus sabaeus	82.99	0.00e+00	2509.00
IUUC-Cho-024512	Choloepus hoffmanni	86.42	0.00e+00	1319.00
IUUC-Csv-026127	Ciona savignyi	71.67	5.00e-153	533.00
IUUC-Dre-028275	Danio rerio	85.08	0.00e+00	1395.00
IUUC-Dno-029963	Dasypus novemcinctus	81.25	0.00e+00	2384.00
IUUC-Dor-030282	Dipodomys ordii	74.24	0.00e+00	1001.00
IUUC-Dme-032217	Drosophila melanogaster	71.06	0.00e+00	646.00
IUUC-Ete-033132	Echinops telfairi	79.26	0.00e+00	1177.00
IUUC-Eca-033978	Equus caballus	82.93	0.00e+00	2530.00
IUUC-Fca-036157	Felis catus	83.45	0.00e+00	2521.00
IUUC-Fal-037110	Ficedula albicollis	93.89	0.00e+00	1537.00
IUUC-Gmo-039291	Gadus morhua	79.38	0.00e+00	1003.00
IUUC-Gga-040821	Gallus gallus	94.71	0.00e+00	1543.00
IUUC-Gac-042181	Gasterosteus aculeatus	87.87	0.00e+00	1405.00
IUUC-Ggo-044862	Gorilla gorilla	82.56	0.00e+00	2395.00
IUUC-Hsa-046219	Homo sapiens	83.30	0.00e+00	2553.00
IUUC-Lch-050526	Latimeria chalumnae	89.80	0.00e+00	1458.00
IUUC-Loc-052648	Lepisosteus oculatus	88.26	0.00e+00	1438.00
IUUC-Laf-054005	Loxodonta africana	82.37	0.00e+00	2515.00
IUUC-Mcc-055314	Macaca mulatta	82.36	0.00e+00	2505.00
IUUC-Meu-056356	Macropus eugenii	80.12	0.00e+00	784.00
IUUC-Mga-060074	Meleagris gallopavo	94.33	0.00e+00	1461.00
IUUC-Mmr-061526	Microcebus murinus	95.59	0.00e+00	1550.00
IUUC-Mdo-063017	Monodelphis domestica	80.44	0.00e+00	2428.00
IUUC-Mmu-064165	Mus musculus	95.47	0.00e+00	1550.00
IUUC-Mlu-067709	Myotis lucifugus	79.91	0.00e+00	2415.00
IUUC-Nle-069308	Nomascus leucogenys	82.99	0.00e+00	2512.00
IUUC-Opr-070330	Ochotona princeps	81.61	0.00e+00	1275.00
IUUC-Ont-071345	Oreochromis niloticus	88.27	0.00e+00	1385.00
IUUC-Ocu-074775	Oryctolagus cuniculus	95.84	0.00e+00	1554.00
IUUC-Ola-087225	Oryzias latipes	84.38	0.00e+00	1288.00
IUUC-Oga-088177	Otolemur garnettii	95.34	0.00e+00	1550.00
IUUC-Oar-089452	Ovis aries	82.85	0.00e+00	2525.00
IUUC-Ptr-090806	Pan troglodytes	83.30	0.00e+00	2525.00
IUUC-Pan-091838	Papio anubis	82.36	0.00e+00	2378.00
IUUC-Psi-094090	Pelodiscus sinensis	76.57	0.00e+00	2390.00
IUUC-Pfo-096520	Poecilia formosa	84.03	0.00e+00	1393.00
IUUC-Pab-098405	Pongo abelii	83.30	0.00e+00	2520.00
IUUC-Pva-102324	Pteropus vampyrus	95.11	0.00e+00	1535.00
IUUC-Rno-105943	Rattus norvegicus	81.36	0.00e+00	2538.00
IUUC-Sha-106985	Sarcophilus harrisii	79.31	0.00e+00	1461.00
IUUC-Sar-113505	Sorex araneus	91.82	0.00e+00	1455.00
IUUC-Ssc-115439	Sus scrofa	76.91	0.00e+00	1568.00
IUUC-Tgu-117078	Taeniopygia guttata	94.14	0.00e+00	1550.00
IUUC-Tru-118671	Takifugu rubripes	87.87	0.00e+00	1372.00
IUUC-Tni-120619	Tetraodon nigroviridis	87.61	0.00e+00	1365.00
IUUC-Ttr-128469	Tursiops truncatus	77.85	0.00e+00	2256.00
IUUC-Vpa-130498	Vicugna pacos	73.60	0.00e+00	2071.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence